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What Is the Specificity of the Aortic Dissection Detection Risk Score in a Low ‐prevalence Population?
ConclusionsOur study confirms that in North America the prevalence of AAS in those undergoing advanced imaging is low. The ADD ‐RS in this population has a low specificity. A lack of defined inclusion criteria and a low specificity limits the application of this rule in practice.
Source: Academic Emergency Medicine - November 20, 2018 Category: Emergency Medicine Authors: Robert Ohle, Omar Anjum, Helena Bleeker, Sarah McIsaac, Brian C. Hiestand Tags: Original Contribution Source Type: research

An Urban 911 System's Experience with Left Ventricular Assist Device Patients.
CONCLUSIONS: EMS interactions with LVAD patients are infrequent but have high rates of admission and incidence of life-threatening diagnoses. The most common prehospital presenting symptoms were weakness and chest pain, and most prehospital interactions did not require LVAD-specific interventions. In addition to acquiring technical knowledge regarding LVADs, EMS providers should be aware of non-device-related complications including intracranial and GI bleeding and take this into account during their assessment. PMID: 30285520 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - October 6, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Acupuncture for acute stroke.
CONCLUSIONS: This updated review indicates that apparently improved outcomes with acupuncture in acute stroke are confounded by the risk of bias related to use of open controls. Adverse events related to acupuncture were reported to be minor and usually did not result in stopping treatment. Future studies are needed to confirm or refute any effects of acupuncture in acute stroke. Trials should clearly report the method of randomization, concealment of allocation, and whether blinding of participants, personnel, and outcome assessors was achieved, while paying close attention to the effects of acupuncture on long-term funct...
Source: Cochrane Database of Systematic Reviews - March 30, 2018 Category: General Medicine Authors: Xu M, Li D, Zhang S Tags: Cochrane Database Syst Rev Source Type: research

Saving Vanessa, part 1: A mystery rash, a stroke and an epic rescue
Vanessa’s rash first appeared on her arms and legs when she 3 or 4 months old. It was red and bumpy and went away when she was sick with a virus, which happened often. Then it would come back. The dermatology team she saw at Boston Children’s Hospital was puzzled. “I was expecting they were going to think it was nothing, but they took it very seriously,” says Katherine Bell, one of Vanessa’s mothers. “They took a biopsy and very quickly realized they had no idea what it was.” Vanessa’s case was even featured at a regional dermatology conference where doctors take up mystery patients. “A hundred to 150 der...
Source: Thrive, Children's Hospital Boston - July 25, 2017 Category: Pediatrics Authors: Nancy Fliesler Tags: Diseases & Conditions Our Patients’ Stories Dr. Carolyn Rogers Dr. Pui Lee Dr. Robert Sundel Dr. Scellig Stone Dr. Todd Lyons stroke Source Type: news

Practice patterns for spasticity management with phenol neurolysis.
CONCLUSION: Phenol neurolysis is currently used to reduce spasticity for various functional goals, including preventing contractures and improving gait. Depending on the pattern of spasticity displayed, numerous peripheral nerves in the upper and lower extremities can be targeted for treatment with phenol neurolysis. Further research into its role in spasticity management, including studies exploring its cost-effectiveness and pharmacological and side-effects compared with other treatment options are needed. PMID: 28537343 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - May 26, 2017 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Characterization of Long-term Gait Deficits in Mouse dMCAO, Using the CatWalk System.
Abstract Evaluation of functional outcome is widely used across species to assess the recovery process following various pathological conditions, including spinal cord injury, musculo-skeletal injury, mithochondrial disease, neuropathic cancer, Huntington's disease, chronic pain, cortical lesion, and olivocerebellar degeneration among others. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends multiple endpoints for behavioral studies in pre-clinical stroke research, to demonstrate their clinical relevance. One of the more challenging tasks in experimental stroke research is measuring long-term func...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Caballero-Garrido E, Pena-Philippides JC, Galochkina Z, Erhardt E, Roitbak T Tags: Behav Brain Res Source Type: research

Interventions for preventing silent cerebral infarcts in people with sickle cell disease.
CONCLUSIONS: We identified no trials for preventing silent cerebral infarcts in adults, or in children who do not have HbSS SCD.Long-term red blood cell transfusions may reduce the incidence of silent cerebral infarcts in children with abnormal TCD velocities, but may have little or no effect on children with normal TCD velocities. In children who are at higher risk of stroke and have not had previous long-term transfusions, long-term red blood cell transfusions probably reduce the risk of stroke, and other SCD-related complications (acute chest syndrome and painful crises).In children and adolescents at high risk of strok...
Source: Cochrane Database of Systematic Reviews - May 13, 2017 Category: General Medicine Authors: Estcourt LJ, Fortin PM, Hopewell S, Trivella M, Doree C, Abboud MR Tags: Cochrane Database Syst Rev Source Type: research

Clinical Factors and Expenditures Associated With ICD ‐9‐CM Coded Trauma for the U.S. Population: A Nationally Representative Study
ConclusionsTrauma results in a significant healthcare expenditure burden, both per person and on the U.S. population. Clinicians should be aware that individuals in the U.S. population with certain comorbidities such as stroke, joint pain, arthritis, and asthma are more likely to have trauma and that differences exist in expenditures for office‐based, outpatient, dental, and the ED.
Source: Academic Emergency Medicine - March 22, 2017 Category: Emergency Medicine Authors: Clara E. Dismuke, Kinfe G. Bishu, Samir Fakhry, Rebekah J. Walker, Leonard E. Egede Tags: Original Contribution Source Type: research

Getting Social in the Real World
Although it would be facetious to say that social media has reached a tipping point into ubiquity, it is only relatively recently that it has been used by pharma to collect and analyze patient data. This use of social media may only be in its infancy but as a quick and inexpensive way to gather large-scale, real-world data it is growing rapidly.Technology always outstrips the glacial pace that industry moves at, but this ‘sudden’ move creates a sharp learning curve for many pharma companies. Issues around regulation and resources will hinder some, while others will fail to see the value of ‘social health’.Popular s...
Source: EyeForPharma - March 6, 2017 Category: Pharmaceuticals Authors: Danielle Barron Source Type: news

Clinical Factors and Expenditures Associated With ICD ‐9‐CM Coded Trauma for the US Population: A Nationally Representative Study
ConclusionsTrauma results in a significant health care expenditure burden, both per person and on the US population. Clinicians should be aware that individuals in the U.S. population with certain comorbidities such as stroke, joint pain, arthritis and asthma are more likely to have trauma, and that differences exist in expenditures for office‐based, outpatient, dental and the ER.This article is protected by copyright. All rights reserved.
Source: Academic Emergency Medicine - December 14, 2016 Category: Emergency Medicine Authors: Clara E. Dismuke, Kinfe G. Bishu, Samir Fakhry, Rebekah J. Walker, Leonard E. Egede Tags: Original Contribution Source Type: research

Tau Imaging Among Breakthroughs Advancing the Fight against Alzheimer ' s
Worldwide,  nearly44 million  people now have Alzheimer ' s disease (AD) or related dementia, making these conditions the  top cause of disabilities in later life. The biopharma industry has invested billions of dollars into research to treat and prevent AD1, yet this work has faced many obstacles, including difficulty identifying biomarkers, tracking the disease ’s progress in the brain, and recruiting patients to trials while they are still asymptomatic. But in recent years, we’ve begun to see breakthroughs that is driving our research in new directions. Many of these accomplishments were highlighted at the Alzh...
Source: EyeForPharma - September 21, 2016 Category: Pharmaceuticals Authors: Olga Uspenskaya-Cadoz Source Type: news

10 Experiments at the Forefront of Sleep Science
As part of the team at Experiment.com, a crowdfunding platform for science, I get to talk to scientists all the time. I've been an insomniac and poor sleeper all my life, so I decided to run a Sleep Challenge Grant to launch a batch of sleep experiments together on the site. Here's what I'm learning from 10 scientists at the forefront of sleep research: Men who go to sleep late have more sex. "Evening men," who naturally wake up later and go to sleep later, tend to have higher mating success but lower success in social settings like school or business. Dr. Christoph Randler wants to investigate whether there are clues fo...
Source: Healthy Living - The Huffington Post - June 9, 2016 Category: Consumer Health News Source Type: news

Facial Colliculus and Opalski Stroke Syndromes Caused by Vertebral Artery Dissection. Case Report (P4.349)
Conclusion: Brainstem stroke syndromes are challenging to localize before brain imaging. In this case two embolic strokes happened. The first in the right facial colliculus causing the right 6th and 7th cranial nerves palsy. The second happened in the left lateral medulla extending below the pyramidal decussation causing a classical left lateral medullary syndrome with ipsilateral hemiparesis, which constitute a left Opalski stroke syndrome.Disclosure: Dr. Alghamdi has nothing to disclose. Dr. Ayoub has nothing to disclose. Dr. Alzahrani has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Alghamdi, S., Ayoub, O., Alzahrani, N. Tags: Cerebrovascular Case Reports Source Type: research

Pain after Cervical Artery Dissection (P4.381)
Conclusions: Chronic pain or new pain development is frequent after spontaneous CAD. Recognition of clinical factors that predict chronic pain could help clinicians manage pain in CAD patients more effectively.Disclosure: Dr. Youn has nothing to disclose. Dr. Prabhakaran has received personal compensation for activities with the American Heart Association.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Youn, J., Prabhakaran, S. Tags: Non-Atherosclerotic Arteriopathies Source Type: research

Perceived Appropriateness of Shared Decision‐Making in the Emergency Department: A Survey Study
ConclusionsAcceptance of SDM among emergency physicians appears to be strong across management categories (diagnostic testing, treatment, and disposition) and in a variety of clinical scenarios. SDM is perceived by most EPs to be medicolegally protective.This article is protected by copyright. All rights reserved.
Source: Academic Emergency Medicine - January 25, 2016 Category: Emergency Medicine Authors: Marc A. Probst, Hemal K. Kanzaria, Dominick L. Frosch, Erik P. Hess, Gary Winkel, Ka Ming Ngai, Lynne D. Richardson Tags: Original Contribution Source Type: research

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