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Condition: Hypertension
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Total 404 results found since Jan 2013.

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype Clinical Sciences
Conclusions— MTHFR C677T was associated with magnetic resonance imaging–confirmed lacunar stroke, but not large artery or cardioembolic stroke. The association may act through increased susceptibility to, or interaction with, high blood pressure. This heterogeneity of association might explain the lack of effect of lowering homocysteine in secondary prevention trials which included all strokes.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Rutten-Jacobs, L. C. A., Traylor, M., Adib-Samii, P., Thijs, V., Sudlow, C., Rothwell, P. M., Boncoraglio, G., Dichgans, M., Meschia, J., Maguire, J., Levi, C., Rost, N. S., Rosand, J., Hassan, A., Bevan, S., Markus, H. S. Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog Basic Sciences
Conclusions—Our data suggest that targeting the IP receptor with MRE-269 is a novel strategy to reduce cerebral ischemia injury and promote long-term neurological recovery in ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Changjun Yang, Kelly M. DeMars, Jon C. Alexander, Marcelo Febo, Eduardo Candelario-Jalil Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke Clinical Sciences
Conclusions—In this magnetic resonance imaging–verified lacunar stroke population, we identified a distinct risk factor profile in the group as a whole. However, there were differing risk factor profiles according to the presence of multiple lacunar infarcts and confluent WMH. The association of hypertension, smoking, and renal impairment with the presence of multiple lacunar infarcts and confluent WMH might reflect a diffuse small vessel arteriopathy.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Hugh S. Markus Tags: Risk Factors, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Serial Alberta Stroke Program Early CT Score From Baseline to 24 Hours in Solitaire Flow Restoration With the Intention for Thrombectomy Study: A Novel Surrogate End Point for Revascularization in Acute Stroke Clinical Sciences
Conclusions— Twenty-four-hour ASPECTS provides better prognostic information compared with baseline ASPECTS. Predictors of dramatic infarct progression on ASPECTS are hyperglycemia, hypertension, and nonreperfusion. Serial ASPECTS change from baseline to 24 hours predicts clinical outcome, providing an early surrogate end point for thrombectomy trials. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01054560.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Liebeskind, D. S., Jahan, R., Nogueira, R. G., Jovin, T. G., Lutsep, H. L., Saver, J. L., for the SWIFT Investigators Tags: Cerebrovascular disease/stroke, Brain Circulation and Metabolism, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Blood Pressure Control among Stroke Patients in Thailand—The i-STROKE Study
Background: Direct correlation between stroke mortality and hypertension calls for a tight blood pressure (BP) control. Our study determined the prevalence of the BP control and evaluated current clinical practices on hypertension management in stroke patients in Thailand.Methods: This multicenter, cross-sectional, retrospective, observational study was carried out between February 2010 and January 2011 and enrolled stroke patients aged 45 years or older with ictus incidence 12,030 days before the enrollment. The events were confirmed by either computerized tomography scan or magnetic resonance imaging. Patient data incl...
Source: Journal of Stroke and Cerebrovascular Diseases - June 24, 2013 Category: Neurology Authors: Samart Nidhinandana, Disya Ratanakorn, Nijasri Charnnarong, Sombat Muengtaweepongsa, Somchai Towanabut, i-STROKE Investigators Tags: Original Articles Source Type: research

Smoking-Thrombolysis Paradox: Recanalization and Reperfusion Rates After Intravenous Tissue Plasminogen Activator in Smokers With Ischemic Stroke Original Contributions
Conclusions— Smoking is independently associated with recanalization and reperfusion, indicating that thrombolytic therapy acts more effectively in smokers; because of small numbers, these results should be considered preliminary. Clinical Trial Registration— URL: http://clinicaltrials.gov. Unique Identifier: NCT00715533.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Kufner, A., Nolte, C. H., Galinovic, I., Brunecker, P., Kufner, G. M., Endres, M., Fiebach, J. B., Ebinger, M. Tags: Fibrinolysis, Angiography, Computerized tomography and Magnetic Resonance Imaging, Risk Factors for Stroke, Thrombolysis Original Contributions Source Type: research

Microbleed Status and 3-Month Outcome After Intravenous Thrombolysis in 717 Patients With Acute Ischemic Stroke Clinical Sciences
Conclusions— Poor outcome or sICH was not associated with CMB presence or burden on pre–intravenous thrombolysis magnetic resonance imaging after adjustment for confounding factors. An individual patient data meta-analysis is needed to determine whether a subgroup of patients with CMBs carries an independent risk of poor outcome that might outweigh the expected benefit of intravenous thrombolysis.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Turc, G., Sallem, A., Moulin, S., Tisserand, M., Machet, A., Edjlali, M., Baron, J.-C., Leclerc, X., Leys, D., Mas, J.-L., Cordonnier, C., Oppenheim, C. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging, Intracerebral Hemorrhage, Thrombolysis Clinical Sciences Source Type: research

Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke Clinical Sciences
Background and Purpose—It has been hypothesized that cerebral small vessel disease (SVD) and chronic renal impairment may be part of a multisystem small-vessel disorder, but their association may simply be as a result of shared risk factors (eg, hypertension) rather than to a systemic susceptibility to premature SVD. However, most previous studies were hospital based, most had inadequate adjustment for hypertension, many were confined to patients with lacunar stroke, and none stratified by age.Methods—In a population-based study of transient ischemic attack and ischemic stroke (OXVASC [Oxford Vascular Study]), we evalu...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Bian Liu, Kui Kai Lau, Linxin Li, Caroline Lovelock, Ming Liu, Wilhelm Kuker, Peter M. Rothwell Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Stroke Risk Factors, Subtypes, and 30-Day Case Fatality in Abuja, Nigeria (P1.121)
CONCLUSIONS: Although hypertension, obesity, diabetes mellitus, and atrial fibrillation were important stroke risk factors, in many patients, these were detected only after a stroke. While the commonest stroke subtype was cerebral infarction, observed in almost two-third of patients, SAH was associated with the highest case-fatality rate at 30 days of 44.4%. Larger population-based studies are planned.Study Supported by: nilDisclosure: Dr. Bwala has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bwala, S. Tags: Cerebrovascular Disease and Interventional Neurology: Ischemic Stroke Subtype Source Type: research

Population-Based Case-Control Study of White Matter Changes on Brain Imaging in Transient Ischemic Attack and Ischemic Stroke Clinical Sciences
Conclusions— In contrast to small vessel ischemic events, WMC were not independently associated with other pathogenic subtypes, suggesting that WMC are unlikely to be an independent risk factor for nonsmall vessel events.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Li, L., Simoni, M., Kuker, W., Schulz, U. G., Christie, S., Wilcock, G. K., Rothwell, P. M. Tags: Computerized tomography and Magnetic Resonance Imaging, Epidemiology Clinical Sciences Source Type: research

Uric Acid Treatment After Stroke Prevents Long-Term Middle Cerebral Artery Remodelling and Attenuates Brain Damage in Spontaneously Hypertensive Rats
AbstractHypertension is the most important modifiable risk factor for stroke and is associated with poorer post-stroke outcomes. The antioxidant uric acid is protective in experimental normotensive ischaemic stroke. However, it is unknown whether this treatment exerts long-term protection in hypertension. We aimed to evaluate the impact of transient intraluminal middle cerebral artery (MCA) occlusion (90  min)/reperfusion (1–15 days) on brain and vascular damage progression in adult male Wistar-Kyoto (WKY;n = 36) and spontaneously hypertensive (SHR;n = 37) rats treated (i.v./120 min post-occlusion) with uric aci...
Source: Translational Stroke Research - September 15, 2018 Category: Neurology Source Type: research

Safety and Effectiveness of Endovascular Treatment after 6 Hours of Symptom Onset in Patients with Anterior Circulation Ischemic Stroke: A Matched Case Control Study
Conclusions: We did not observe any evidence of benefit in halting neurologic worsening or improving outcomes among patients undergoing endovascular treatment for treatment of an anterior circulation ischemic stroke after 6 hours of symptom onset. Strong evidence of both the safety and efficacy of emergent endovascular treatment when administered to patients with stroke in the anterior circulation is needed.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2012 Category: Neurology Authors: Adnan I. Qureshi, Jefferson T. Miley, Saqib A. Chaudhry, Edouard Semaan, Gustavo J. Rodriguez, M.Fareed K. Suri, Harold P. Adams Tags: Original Articles Source Type: research

Clinical–MRI correlations in a multiethnic cohort with recent lacunar stroke: the SPS3 trial
ConclusionsIn patients with recent lacunar stroke, infarct location and number have distinctie associations with gender, vascular risk factors, and race‐ethnicity, demonstrating the complex pathogenesis of lacunar stroke and cerebral small artery disease.
Source: International Journal of Stroke - May 27, 2014 Category: Neurology Authors: Oscar R. Benavente, Lesly A. Pearce, Carlos Bazan, Ana M. Roldan, Luciana Catanese, Viveca M. Bhat Livezey, Gabriela Vidal‐Pergola, Leslie A. McClure, Robert G. Hart, Tags: Research Source Type: research

Predictors of Good Outcome After Stent-Retriever Thrombectomy in Acute Basilar Artery Occlusion Brief Reports
Conclusions— This study suggested that initial infarction severity and posterior circulation Acute Stroke Prognosis Early CT Score on a pretreatment DWI are independent predictors of clinical outcome after stent-retriever thrombectomy in patients with acute basilar artery occlusion.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Yoon, W., Kim, S. K., Heo, T. W., Baek, B. H., Lee, Y. Y., Kang, H. K. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Computerized tomography and Magnetic Resonance Imaging Brief Reports Source Type: research