Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype [Clinical Sciences]

Conclusions—
MTHFR C677T was associated with magnetic resonance imaging–confirmed lacunar stroke, but not large artery or cardioembolic stroke. The association may act through increased susceptibility to, or interaction with, high blood pressure. This heterogeneity of association might explain the lack of effect of lowering homocysteine in secondary prevention trials which included all strokes.

Source: Stroke - February 22, 2016 Category: Neurology Authors: Rutten-Jacobs, L. C. A., Traylor, M., Adib-Samii, P., Thijs, V., Sudlow, C., Rothwell, P. M., Boncoraglio, G., Dichgans, M., Meschia, J., Maguire, J., Levi, C., Rost, N. S., Rosand, J., Hassan, A., Bevan, S., Markus, H. S. Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research