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Study on the predictive ability of emergency CHADS < sub > 2 < /sub > score and CHA < sub > 2 < /sub > DS < sub > 2 < /sub > -VASc score for coronary artery disease and prognosis in patients with acute ST-segment elevation myocardial infarction
CONCLUSIONS: Multiple factors jointly affect the severity and prognosis of CAD in patients with acute STEMI. The CHA2DS2-VASc score is better than the CHADS2 score in predicting the severity of coronary artery lesions and prognosis of patients, providing theoretical support for clinical practice.PMID:35928606 | PMC:PMC9344425 | DOI:10.21037/jtd-22-763
Source: Journal of Thoracic Disease - August 5, 2022 Category: Respiratory Medicine Authors: Xin Huang Hong Lv Zeyan Liu Yuan Liu Xue Yang Source Type: research

Acute Hemodynamic Effects of Riociguat in Patients with Pulmonary Hypertension Associated with Diastolic Heart Failure (DILATE-1): A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study.
Conclusions:In patients with HFpEF and PH, riociguat was well tolerated, had no significant effect on mPAP, and improved exploratory hemodynamic and echocardiographic parameters. Trial registry:ClinicalTrials.gov; No.: NCT01172756; URL: www.clinicaltrials.gov. Background: Deficient nitric oxide- soluble guanylate cyclase (sGC)-cGMP signaling results from endothelial dysfunction and may underlie impaired cardiac relaxation in patients with heart failure with preserved left ventricular ejection fraction (HFpEF) and pulmonary hypertension (PH). The acute hemodynamic effects of riociguat, a novel sGC stimulator, were char...
Source: Chest - July 3, 2014 Category: Respiratory Medicine Authors: Bonderman D, Pretsch I, Steringer-Mascherbauer R, Jansa P, Rosenkranz S, Tufaro C, Bojic A, Lam CS, Frey R, Ochan Kilama M, Unger S, Roessig L, Lang IM Tags: Chest Source Type: research

Obstructive sleep apnea is a common disorder in the population-a review on the epidemiology of sleep apnea.
Authors: Franklin KA, Lindberg E Abstract The prevalence of obstructive sleep apnea (OSA) defined at an apnea-hypopnea index (AHI) ≥5 was a mean of 22% (range, 9-37%) in men and 17% (range, 4-50%) in women in eleven published epidemiological studies published between 1993 and 2013. OSA with excessive daytime sleepiness occurred in 6% (range, 3-18%) of men and in 4% (range, 1-17%) of women. The prevalence increased with time and OSA was reported in 37% of men and in 50% of women in studies from 2008 and 2013 respectively. OSA is more prevalent in men than in women and increases with age and obesity. Smoking and al...
Source: Journal of Thoracic Disease - September 20, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database.
Abstract Obstructive sleep apnoea (OSA) is a highly prevalent condition but studies exploring the burden of OSA-associated comorbidities have been limited by small sample sizes with underrepresentation of women.We queried the Truven Health MarketScan Research Databases 2003-2012, which is a collection of health insurance claims for working adults and retirees with employer-sponsored health insurance. Adults with a diagnostic code for OSA with at least 12 months of follow-up from the index date of OSA diagnosis were compared to a matched random sample. Comorbidities were assessed using International Classificatio...
Source: Respiratory Care - January 21, 2016 Category: Respiratory Medicine Authors: Mokhlesi B, Ham SA, Gozal D Tags: Eur Respir J Source Type: research

Rat models of cardiometabolic diseases: baseline clinical chemistries, and rationale for their use in examining air pollution health effects.
Authors: Kodavanti UP, Russell JC, Costa DL Abstract Individuals with cardiovascular and metabolic diseases (CVD) are shown to be more susceptible to adverse health effects of pollutants. Rodent models of CVD are used for examining susceptibility variations. CVD models developed by selective inbreeding are shown to represent the etiology of human disease and metabolic dysfunction. The goal of this article was to review the origin and the pathobiological features of rat models of varying CVD with or without metabolic syndrome and healthy laboratory rat strains to allow better interpretation of the data regarding the...
Source: Inhalation Toxicology - February 18, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database
Obstructive sleep apnoea (OSA) is a highly prevalent condition but studies exploring the burden of OSA-associated comorbidities have been limited by small sample sizes with underrepresentation of women. We queried the Truven Health MarketScan Research Databases 2003–2012, which is a collection of health insurance claims for working adults and retirees with employer-sponsored health insurance. Adults with a diagnostic code for OSA with at least 12 months of follow-up from the index date of OSA diagnosis were compared to a matched random sample. Comorbidities were assessed using International Classification of Dis...
Source: European Respiratory Journal - March 31, 2016 Category: Respiratory Medicine Authors: Mokhlesi, B., Ham, S. A., Gozal, D. Tags: Sleep medicine Original Articles: Sleep Source Type: research

Comparisons of sleep apnoea rate and outcomes among patients with resistant and non‐resistant hypertension
ConclusionWe observed a modest increase in likelihood for SA among RH compared to non‐RH patients. Risks for IHE and CHF were higher for SA in RH compared to SA in non‐RH patients; however, there were no differences in risk for stroke and mortality.
Source: Respirology - July 17, 2016 Category: Respiratory Medicine Authors: Simran K. Bhandari, Jiaxiao Shi, Miklos Z. Molnar, Scott A. Rasgon, Stephen F. Derose, Csaba P. Kovesdy, David A. Calhoun, Kamyar Kalantar‐zadeh, Steven J. Jacobsen, John J. Sim Tags: Original Article Source Type: research

Comparisons of sleep apnoea rate and outcomes among patients with resistant and non ‐resistant hypertension
ConclusionWe observed a modest increase in likelihood for SA among RH compared to non‐RH patients. Risks for IHE and CHF were higher for SA in RH compared to SA in non‐RH patients; however, there were no differences in risk for stroke and mortality.
Source: Respirology - July 17, 2016 Category: Respiratory Medicine Authors: Simran K. Bhandari, Jiaxiao Shi, Miklos Z. Molnar, Scott A. Rasgon, Stephen F. Derose, Csaba P. Kovesdy, David A. Calhoun, Kamyar Kalantar ‐zadeh, Steven J. Jacobsen, John J. Sim Tags: Original Article Source Type: research

Prevalence of common diseases in COPD patients versus lung-healthy control subjects: Results from the German COSYCONET study
COSYCONET investigates the interrelationship of COPD and comorbidities with regard to course and prognosis of the disease. The present analysis examined the prevalence of selected common diseases in the COPD cohort compared to apparently lung-healthy subjects from the population-based reference cohorts KORA and SHIP.Spirometry was performed in all subjects and COPD patients were graded according to GOLD criteria. Subjects from KORA/SHIP without known COPD, asthma or chronic bronchitis and with FEV1/FVC≥0.7 were regarded as apparently lung-healthy. Prevalences of myocardial infarction, stroke, diabetes, hypertension, obe...
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Karrasch, S., Obst, A., Söhler, S., Thorand, B., Huth, C., Ladwig, K.-H., Flexeder, C., Wacker, M., Peters, A., Heinrich, J., Ewert, R., Nowak, D., Jörres, R. A., Vogelmeier, C., Gläser, S., Schulz, H., COSYCONET Study Group Tags: 6.1 Epidemiology Source Type: research

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