Prevalence of common diseases in COPD patients versus lung-healthy control subjects: Results from the German COSYCONET study

COSYCONET investigates the interrelationship of COPD and comorbidities with regard to course and prognosis of the disease. The present analysis examined the prevalence of selected common diseases in the COPD cohort compared to apparently lung-healthy subjects from the population-based reference cohorts KORA and SHIP.Spirometry was performed in all subjects and COPD patients were graded according to GOLD criteria. Subjects from KORA/SHIP without known COPD, asthma or chronic bronchitis and with FEV1/FVC≥0.7 were regarded as apparently lung-healthy. Prevalences of myocardial infarction, stroke, diabetes, hypertension, obesity and cancer were compared between COPD patients and lung-healthy subjects using logistic regression analysis accounting for sex, age and smoking status.2741 COPD patients and 4729 lung-healthy subjects were included in the analysis (age range 40-90y). The percentage of males was higher in the COPD cohort compared to the lung-healthy subjects (59% vs. 49%).The disease prevalences in COPD patients vs. controls were 8% vs. 4% for myocardial infarction, 4% vs. 3% for stroke, 14% vs. 10% for diabetes, 56% vs. 41% for hypertension, 11% vs. 7% for cancer and 25% vs. 31% for obesity. In the logistic regression analysis the associations between COPD and disease prevalence were significant for myocardial infarction, hypertension and obesity (p<0.05 each).The COPD patients showed a higher prevalence of myocardial infarction and hypertension and a lower prevalenc...

Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Karrasch, S., Obst, A., Söhler, S., Thorand, B., Huth, C., Ladwig, K.-H., Flexeder, C., Wacker, M., Peters, A., Heinrich, J., Ewert, R., Nowak, D., Jörres, R. A., Vogelmeier, C., Gläser, S., Schulz, H., COSYCONET Study Group Tags: 6.1 Epidemiology Source Type: research