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Total 10881 results found since Jan 2013.

Volume responsiveness revisited: an observational multicentre study of continuous versus binary outcomes combining echocardiography and venous return physiology
In conclusion, venous return physiology may enhance echocardiographic assessments of volume responsiveness, that should be based on continuous changes in stroke volume.PMID:37682234 | DOI:10.1152/ajpheart.00375.2023
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Anders Aneman Luis Schulz Gwena ël Prat Michel Slama Philippe Vignon Antoine Vieillard-Baron Source Type: research

Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study
This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study. The active group included patients who developed HT during hospitalization (55 persons). There were no significant differences in age, gender distribution, time to admission, or time to blood sample collection for MMPs measurement between patients in the active and control groups. IS patients from...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Elena Costru-Tasnic Mihail Gavriliuc Elena Manole Source Type: research

Diabetes mellitus and functional limitations among older adults: Evidence from a large, representative Ghanaian aging study
CONCLUSIONS: In this representative study, older adults with DM showed higher odds for FL, and this association was partially explained by physical activity and health variables. Investing in a holistic management approach might be helpful for public health planning efforts to address DM-induced FL in old age.PMID:37677886 | DOI:10.1016/j.jpsychores.2023.111481
Source: Pain Physician - September 7, 2023 Category: Anesthesiology Authors: Razak M Gyasi Julius Odei Mohammed Gazali Hambali Nelson Gyasi-Boadu Bernard Obeng Moses Asori Andr é Hajek Louis Jacob Yvonne Ami Dodzi Adjakloe Jones Opoku-Ware Lee Smith Ai Koyanagi Source Type: research

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study
This study aimed to investigate the potential prognosis role of non-specific laboratory data at admission and baseline MMP-2 and MMP-9 serum levels in predicting HT risk, discharge, and 3-month follow-up status of IS patients. Data from 150 successive acute cerebral infarction patients were analyzed in a prospective cohort study. The active group included patients who developed HT during hospitalization (55 persons). There were no significant differences in age, gender distribution, time to admission, or time to blood sample collection for MMPs measurement between patients in the active and control groups. IS patients from...
Source: Journal of Medicine and Life - September 7, 2023 Category: General Medicine Authors: Elena Costru-Tasnic Mihail Gavriliuc Elena Manole Source Type: research

Disparities in ethnicity and metabolic disease burden in referrals to nephrology
CONCLUSION: A disproportionately large number of Malay patients are referred for kidney disease. These patients have higher metabolic disease burden, tend to miss appointments and are referred at lower eGFR. Reasons underpinning these associations should be identified to facilitate efforts for targeting this at-risk population, ensuring kidney health for all.PMID:37675684 | DOI:10.4103/singaporemedj.SMJ-2022-193
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Yan Ting Chua Cheang Han Leo Horng Ruey Chua Weng Kin Wong Gek Cher Chan Anantharaman Vathsala Ye Lu Mavis Gan Boon Wee Teo Source Type: research

Diabetes mellitus and functional limitations among older adults: Evidence from a large, representative Ghanaian aging study
CONCLUSIONS: In this representative study, older adults with DM showed higher odds for FL, and this association was partially explained by physical activity and health variables. Investing in a holistic management approach might be helpful for public health planning efforts to address DM-induced FL in old age.PMID:37677886 | DOI:10.1016/j.jpsychores.2023.111481
Source: Pain Physician - September 7, 2023 Category: Anesthesiology Authors: Razak M Gyasi Julius Odei Mohammed Gazali Hambali Nelson Gyasi-Boadu Bernard Obeng Moses Asori Andr é Hajek Louis Jacob Yvonne Ami Dodzi Adjakloe Jones Opoku-Ware Lee Smith Ai Koyanagi Source Type: research

Disparities in ethnicity and metabolic disease burden in referrals to nephrology
CONCLUSION: A disproportionately large number of Malay patients are referred for kidney disease. These patients have higher metabolic disease burden, tend to miss appointments and are referred at lower eGFR. Reasons underpinning these associations should be identified to facilitate efforts for targeting this at-risk population, ensuring kidney health for all.PMID:37675684 | DOI:10.4103/singaporemedj.SMJ-2022-193
Source: Singapore Medical Journal - September 7, 2023 Category: General Medicine Authors: Yan Ting Chua Cheang Han Leo Horng Ruey Chua Weng Kin Wong Gek Cher Chan Anantharaman Vathsala Ye Lu Mavis Gan Boon Wee Teo Source Type: research