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Total 204 results found since Jan 2013.

Risk of warfarin-associated intracerebral haemorrhage after ischaemic stroke is low and unchanged during the 2000s
Commentary on: Asberg A, Erisksson M, Henriksson KM, et al.. Warfarin-associated intracerebral hemorrhage after ischemic stroke. Stroke 2014;45:2118–20. Context Since its isolation during the early half of the 20th century from the mouldy hay responsible for ‘sweet clover disease’ in cattle, warfarin has become the most widely used oral anticoagulant.1 Indications include atrial fibrillation (AF), mechanical prosthetic valves and venous thromboembolism treatment.2 Warfarin reduces stroke risk in patients with AF by nearly two-thirds; AF accounts for 20% of ischaemic strokes, which tend to be more severe t...
Source: Evidence-Based Medicine - January 21, 2015 Category: Internal Medicine Authors: Ruland, S., Biller, J. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Alcohol-related disorders, Drugs misuse (including addiction), Arrhythmias, Alcohol, Health education Aetiology/Harm Source Type: research

Increasing the Risk of Stroke by Opium Addiction
Stroke is among the leading causes of mortality and morbidity in the world. Besides the identified risk factor, Ischemic stroke evidence show drug use develops or exacerbates the atherosclerotic process. The current study aimed at comparing cerebrovascular ultrasounds ’ changes in addicted and nonaddicted people who developed ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2019 Category: Neurology Authors: Seyed Mohammad Mousavi-Mirzaei, Abolfazl Talebi, Alireza Amirabadizadeh, Samaneh Nakhaee, Ghodsieh Azarkar, Omid Mehrpour Source Type: research

Delayed Varenicline Administration Reduces Inflammation and Improves Forelimb Use Following Experimental Stroke
Pharmacological activation of the cholinergic anti-inflammatory pathway (CAP), specifically by activating α7 nicotinic acetylcholine receptors, has been shown to confer short-term improvements in outcome. Most studies have investigated administration within 24 hours of stroke, and few have investigated drugs approved for use in human patients. We investigated whether delayed administration of varenicli ne, a high-affinity agonist at α7 nicotinic receptors and an established therapy for nicotine addiction, decreased brain inflammation and improved functional performance in a mouse model of experimental stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2017 Category: Neurology Authors: Siyi Chen, Laura Bennet, Ailsa L. McGregor Source Type: research

Gender Difference in Stroke: Are They Different in India? (P1.261)
Conclusion: The incidence rate was higher in men as compared to women. There were differences in risk factors and stroke type. There were no gender differences seen in stroke outcome. Acknowledgement: The Indian Council of Medical Research Task Force Project.Disclosure: Dr. Kaur has nothing to disclose. Dr. Pandian has received personal compensation for activities with Intas Pharmaceuticals and Sanofi-Aventis as an advisor. Dr. Singh has nothing to disclose. Dr. Bansal has nothing to disclose. Dr. Paul has nothing to disclose. Dr. Singla has nothing to disclose. Dr. Singh has nothing to disclose. Dr. Samuel has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kaur, P., Pandian, J., Singh, G., Bansal, R., Paul, B., Singla, M., Singh, S., Samuel, C. Tags: Cerebrovascular Disease: Health Disparities Source Type: research

Cannabis Use and Stroke: Does a Risk Exist?
Conclusions: In people with cannabis use, the prevalence of ischemic stroke and hemorrhagic stroke was 1.2% and 0.3%, respectively, higher than the prevalence of people without use (0.8% and 0.2%). There is insufficient information on timing, exposure, duration, and dose-responsive relationship.
Source: Journal of Addiction Medicine - March 1, 2022 Category: Addiction Tags: Original Research Source Type: research

Anticoagulation and antiplatelet therapy for stroke prevention in atrial fibrillation patients in clinical practice of district hospital in Poland.
CONCLUSIONS: (1). Despite of high stroke risk determined by both scales only 39% of patients received OAC. (2). In the analyzed material the independent predictive factor in this group for prescribing OAC at discharge was arterial hypertension (in accordance with recommendations) and: the younger patients age, no history of stroke/TIA and other than paroxysmal type of AF. (3). Practice of the usage of OAC and/or antiplatelet therapy in AF patients discharged from Polish district hospital was in concordance with current guidelines of ESC neither in 2006 nor 2010. PMID: 23990227 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - August 30, 2013 Category: Cardiology Authors: Bednarski J, Cieszewska E, Strzelecki A, Filipiak KJ Tags: Kardiol Pol Source Type: research

Executive (dys)function after stroke: special considerations for behavioral pharmacology
Stroke is a worldwide leading cause of death and long-term disability with concurrent secondary consequences that are largely comprised of mood dysfunction, as well as sensory, motor, and cognitive deficits. This review focuses on the cognitive deficits associated with stroke specific to executive dysfunction (including decision making, working memory, and cognitive flexibility) in humans, nonhuman primates, and additional animal models. Further, we review some of the cellular and molecular underpinnings of the individual components of executive dysfunction and their neuroanatomical substrates after stroke, with an emphasi...
Source: Behavioural Pharmacology - September 15, 2018 Category: Drugs & Pharmacology Tags: Review Articles Source Type: research

Analysis of comorbidities in hospitalized patients for ischemic stroke and their effects on lethality.
CONCLUSION: This study demonstrates that medico-administrative databases and factorial statistical methods are perfectly adapted to confirm the ischemic stroke risk factors. This type of study will allow to target with more precision the secondary and tertiary prevention actions of stroke. PMID: 31542203 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - September 17, 2019 Category: Cardiology Authors: Savsin M, Dubourg D, Coppieters Y, Collart P Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Is addictive-like eating an overlooked stroke risk factor? A study case.
CONCLUSION: Food addiction might be considered as an emerging stroke risk factor. We suggest it fosters the need to take into consideration addictive-like eating behaviors and associated mental disorders in the primary and secondary prevention of stroke. This may be particularly relevant for the prevention of stroke in women as they are more prone to comfort their emotions with food. LEVEL OF EVIDENCE: V, descriptive study. PMID: 33559834 [PubMed - as supplied by publisher]
Source: Eating and weight disorders : EWD - February 9, 2021 Category: Eating Disorders & Weight Management Authors: Rabat Y, Berthoz S, Sibon I Tags: Eat Weight Disord Source Type: research

A Comprehensive Systematic Review and Meta-analysis on the Risk Factors of Stroke in Iranian Population.
CONCLUSION: The present systematic review and meta-analysis provided a summary of the most important SRFs, which are potentially modifiable and preventable. Overall, Iran, similar to many other LMICs, is experiencing an ever-increasing rate of stroke-prone elderly people. The LMICs are thus suggested to develop national approaches to recognize and address VRFs, to monitor and control CS and OD rates, and to encourage a healthy lifestyle. PMID: 33588570 [PubMed - in process]
Source: Archives of Iranian Medicine - January 1, 2021 Category: Middle East Health Authors: Tabrizi R, Lankarani KB, Kardeh B, Akbari H, Azarpazhooh MR, Borhani-Haghighi A Tags: Arch Iran Med Source Type: research

Hospital Readmissions following Stroke: a Retrospective Study (P6.270)
Conclusions:These results suggest that early inpatient and post-hospitalization interventions to address alcohol abuse and homelessness during the index hospital admission may reduce the rate of hospital readmission within 30 days. The results have prompted interventions on the stroke service such as early inpatient social work and addiction medicine involvement and closer post-discharge follow-up for patients with risk factors of alcohol abuse and homelessness.Disclosure: Dr. Parikh has nothing to disclose. Dr. George has nothing to disclose. Dr. Liyanage-Don has nothing to disclose. Dr. Hohler has nothing to disclose. Dr...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parikh, S., George, P., Liyanage-Don, N., Hohler, A., Denis, R., Weinberg, J. Tags: Cerebrovascular Disease Health Services Research Source Type: research

A Comprehensive Systematic Review and Meta-analysis on the Risk Factors of Stroke in Iranian Population
CONCLUSION: The present systematic review and meta-analysis provided a summary of the most important SRFs, which are potentially modifiable and preventable. Overall, Iran, similar to many other LMICs, is experiencing an ever-increasing rate of stroke-prone elderly people. The LMICs are thus suggested to develop national approaches to recognize and address VRFs, to monitor and control CS and OD rates, and to encourage a healthy lifestyle.PMID:33588570 | DOI:10.34172/aim.2021.10
Source: Archives of Iranian Medicine - February 16, 2021 Category: Middle East Health Authors: Reza Tabrizi Kamran B Lankarani Bahareh Kardeh Hamed Akbari Mahmoud Reza Azarpazhooh Afshin Borhani-Haghighi Source Type: research

Increase of Cry 1 expression is a common phenomenon of the disturbed circadian clock in ischemic stroke and opioid addiction
Biochem Biophys Res Commun. 2021 Apr 21;558:8-13. doi: 10.1016/j.bbrc.2021.04.053. Online ahead of print.ABSTRACTIncreasing evidences suggest the involvement of disrupted circadian clock in various pathologies including stroke and substance abuse. Here we took an attempt to do a comparative study on the regulation of circadian clock gene expression under two pathological circumstances - Opioid addiction and Ischemic stroke in the same cell line model (human neuroblastoma SH-SY5Y cells). To mimic in vivo ischemic stroke condition cells were placed in a hypoxia chamber and incubated for 10 h in balanced salt solution lacking...
Source: Biochemical and Biophysical Research communications - April 24, 2021 Category: Biochemistry Authors: Kaninika Roy Daytee Maji Ishani Deb Source Type: research