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Condition: Poisoning

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Total 262 results found since Jan 2013.

Short answer question case series: a dangerous cause of dyspnoea
Case vignette A 52-year-old man with hepatitis C and a remote history of recreational drug abuse presents with several days of shortness of breath, cough and malaise. He was seen at an outside hospital and diagnosed with pneumonia given his cough and shortness of breath. Subsequently, he was seen again and found to have a small abscess of his arm that was drained. On review of systems, he endorses nausea and generalised weakness but denies abdominal pain, chest pain, numbness, fever, headache or dizziness. On physical exam, he is afebrile but tachypnoeic, has decreased breath sounds at the bases, and has an appropriately h...
Source: Emergency Medicine Journal - July 19, 2013 Category: Emergency Medicine Authors: Woodfield, A., Runde, D., Jang, T. Tags: Poisoning/Injestion, Foodborne infections, Hepatitis and other GI infections, Pneumonia (infectious disease), TB and other respiratory infections, Cranial nerves, Headache (including migraine), Pain (neurology), Stroke, Drugs misuse (including addiction), Source Type: research

Bill Bowman obituary
Pharmacologist and academic who made a huge contribution in the field of anaesthesiaAnyone who has had a general anaesthetic in the last 40 years has reason to be grateful to Bill Bowman, who has died aged 83. Bill played a pivotal role in both understanding how muscle-relaxing drugs work and developing safer and shorter-acting replacements.A person under anaesthetic twitches alarmingly unless a drug is used for "paralysis" or temporary muscle relaxation. This allows surgery in the chest and abdomen without the need for very deep anaesthesia and makes it possible for a tube to be passed into the windpipe to keep a patient'...
Source: Guardian Unlimited Science - August 20, 2013 Category: Science Authors: Caroline Richmond Tags: theguardian.com Obituaries Medical research Pharmacy and pharmacology Second world war Scotland University of Strathclyde Medicine Education Source Type: news

Toxic lipstick, carbon monoxide tragedy, laundry detergent pod death: Weekly Web Review in Toxicology
Meth Labs and the Pharmaceutical Industry: Jonah Engle’s article in Mother Jones — “Merchants of Meth: How Big Pharma Keeps the Cooks in Business” — is compelling reading. The piece details how some drug companies lobbying firms are fighting efforts to control sale of the  meth precursor pseudoephedrine: As law enforcement agencies scramble to clean up and dispose of toxic [meth] labs, prosecute cooks, and find foster homes for their children, they are waging two battles: one against destitute, strong-out addicts, the other against some of the world’s wealthiest and most politically connected ...
Source: The Poison Review - August 21, 2013 Category: Toxicology Authors: Leon Tags: Medical big pharma carbon monoxide heavy metals laundry detergent pod methamphetamine toxic lipstick Source Type: news

Heparin, grad students, a clinical revolution and giving credit where it's due
The story of a grad student who overcame remarkable odds only to be denied his moment of glory, or a tale of dark deceit and devilish doings? The story of heparin is as complicated as the chemistry itselfBlood is remarkable.A liquid that carries nutrients, waste products and the ever-vigilant cells of the immune system around the body, blood rapidly turns into a solid when it leaves its veins and arteries and becomes exposed to bodily tissues or the air outside. This process of solidification – clotting, or coagulation – is executed and controlled by a complex set of reactions and interactions primarily involving the e...
Source: Guardian Unlimited Science - September 4, 2013 Category: Science Authors: Richard P Grant Tags: theguardian.com Blogposts Science Source Type: news

Adderall® (Amphetamine-Dextroamphetamine) Toxicity
This article discusses our present understanding of Adderall® intoxication and examines 3 dogs presented to our practice after ingestion of large amounts of the drug.
Source: Topics in Companion Animal Medicine - February 1, 2013 Category: Veterinary Research Authors: Kevin T. Fitzgerald, Alvin C. Bronstein Source Type: research

Does an Alzheimer's disease susceptibility gene influence the cognitive effects of cancer therapy?
Abstract The apolipoprotein E (APOE) e4 allele is the most prevalent genetic risk factor for Alzheimer's disease (AD). APOE e4 carriers suffer greater morbidity from head trauma, stroke, and carbon monoxide poisoning, yet possible interactions between APOE genotype and cancer therapy on cognition are unclear. Neuropathological and biomarker studies of young asymptomatic APOE e4 carriers that show elevated neocortical amyloid and medial temporal neurofibrillary tangles and longitudinal neuropsychological studies that show accelerated memory decline beginning around age 55–60 years define preclinical AD and have set the st...
Source: Pediatric Blood and Cancer - September 17, 2013 Category: Cancer & Oncology Authors: Richard J. Caselli Tags: Review Source Type: research

S100B protein in children with carbon monoxide poisoning
S100B has been shown to increase in patients with cardiac arrest, stroke, subarachnoid hemorrhage, and traumatic and hypoxic brain damage . In contrast to adult studies, we found that serum S100B protein levels did not increase in pediatric patients with carbon monoxide (CO) poisoning . Patients with a positive history of CO exposure and elevated blood carboxyhemoglobin (>10%) levels associated with relevant clinical findings were diagnosed with CO poisoning. The most common complaints were headache (n = 27), dizziness (n = 27), nausea and vomiting (n = 28), syncope (n = 7), and convulsion (n = 2). In addition, we also cla...
Source: The American Journal of Emergency Medicine - August 12, 2013 Category: Emergency Medicine Authors: Ahmet Zulfikar Akelma, Aydin Celik,, Osman Ozdemir, Fatma Kavak Akelma Tags: Correspondence Source Type: research

Was Arafat poisoned by radioactive polonium?
Yasser Arafat The Maybe-Murder of Yasser Arafat: In a must-read post on Wired Science Blogs, Deborah Blum points out that despite the recent confirmation of traces of radioactive polonium-210 in the exhumed remains of Palestinian Liberation Organization chairman Yasser Arafat, it is far from certain that he died of radiation poisoning. In October 2004, a month before he died, Arafat developed vomiting and abdominal pain. The symptoms were so severe that he was transferred from his home on the West Bank to a hospital in France. The direct cause of Arafat’s death — which occurred on November 11 — was a hemorrha...
Source: The Poison Review - November 12, 2013 Category: Toxicology Authors: Leon Tags: Medical acute radiation syndrome arafat cesium himalayan mountain salt hypokalemia pablo neruda poisoning polonium-210 radioactivity smacc 2013 weekly web review in toxicology Source Type: news

Emergency department visits in Colorado associated with smoking synthetic cannabinoids
3 out of 5 stars Severe Illness Associated with Reported Use of Synthetic Marijuana — Colorado, August-September 2013. MMWR 2013 Dec 13;62:1016-1017. Full Text In August and September of this year, it became apparent to the Colorado Department of Public Health and Environment (CDPHE) that there was a significant increase in the number of patients visiting emergency departments after smoking synthetic marijuana products. Therefore, the Department sent out a request to all EDs in the state to report patients seen on or after August 21 with altered mental status after using any form of synthetic marijuana. To study this pr...
Source: The Poison Review - December 13, 2013 Category: Toxicology Authors: Leon Tags: Medical colorado crazy clown denver spice synthetic cannabinoid Source Type: news

Combined Treatment of Methylprednisolone Pulse and Memantine Hydrochloride Prompts Recovery from Neurological Dysfunction and Cerebral Hypoperfusion in Carbon Monoxide Poisoning: A Case Report
A 49-year-old healthy man developed sudden unconsciousness under inadequate ventilation. Blood gas analysis showed carboxyhemoglobin of 7.3%. After normobaric oxygen therapy, he recovered completely 7 days later. At 3 weeks after carbon monoxide (CO) exposures, memory and gait disturbances appeared. Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. Brain fluid-attenuated inversion recovery imaging disclosed symmetric hypointense lesions in the thalamus and the globus pallidus, and hyperintense lesions in the cerebral w...
Source: Journal of Stroke and Cerebrovascular Diseases - June 21, 2013 Category: Neurology Authors: Konosuke Iwamoto, Ken Ikeda, Sunao Mizumura, Kazuhiro Tachiki, Masaru Yanagihashi, Yasuo Iwasaki Tags: Case Reports Source Type: research

Akinetic Mutism And Parkinsonian Features Progressing To Coma Following A Hypoxic Event With Extended Lucid Interval: Manifestations Of Delayed Post-Hypoxic Leukoencephalopathy (P4.033)
CONCLUSIONS: Clinical anticipation and recognition of DPHL should lead to earlier diagnosis and higher-value care.Disclosure: Dr. Doerner Rinaldi has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Czeisler has nothing to disclose. Dr. Willey has nothing to disclose. Dr. John has nothing to disclose. Dr. Claassen has nothing to disclose. Dr. Mayer has received personal compensation for activities with Actelion, Baxter, Biogen Idec, Codman/Johnson & Johnson Company, CSL Behring, Cornerstone Therapeutics, CR Bard, Novartis, Orsan Technologies, Pfizer Inc, Sage Therapeutics, and Stryker. Dr. Mayer has receive...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Doerner Rinaldi, A. P., Miller, E., Czeisler, B., Willey, J., John, C., Claassen, J., Mayer, S., Agarwal, S. Tags: General Neurology III Source Type: research

Unusual Presentation of Acute Carbon Monoxide Poisoning (P6.024)
CONCLUSIONCO poisoning should be included in the differential diagnosis of patients found to have isolated bilateral thalamic involvement. MR imaging undertaken in acute setting aids in management and prognosis. Follow-up is required to assess for the development of Delayed Neuropsychiatric Syndrome, which can cause changes in personality, memory and gait.Disclosure: Dr. Bains has nothing to disclose. Dr. Reid has nothing to disclose. Dr. Huang has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Bains, S., Reid, D., Huang, X. Tags: General Neurology VI Source Type: research

Medtronic acquires Covidien in a $43 billion deal | Medtech Wall Street news for the week of June 16, 2014
Here's a look at some of the top Wall Street stories for medical device companies this week: Blockbuster: Medtronic in $43B deal to acquire Covidien; Medtronic buyout holds $80M in golden parachutes for Covidien execs; FDA wants another panel hearing on Boston Scientific's Watchman anti-stroke device; European Commission tables review of Zimmer's $13B acquisition of Biomet; Ackman takes Allergan to court to defend against poison pill Blockbuster: Medtronic in $43B deal to acquire Covidien June 16, 2014 by Brad Perriello Zimmer Holdings, Biomet, Boston Scientific, Covidien, European Commission, Food & Drug ...
Source: Mass Device - June 19, 2014 Category: Medical Equipment Authors: MassDevice Source Type: news

Does cannabis cause acute coronary syndromes?
2 out of 5 stars Is recent cannabis use associated with acute coronary syndromes? An illustrative case series. Casier I et al. Acta Cardiol 2014 Apr;69:131-136. Abstract Tetrahydrocannabinol (THC) has a number of well-documented effects on the cardiovascular system: increased heart rate increased blood pressure decreased peripheral vascular resistance orthostatic hypotension THC may also be associated in rare cases with induction of ventricular arrhythmias. In addition, smoking marijuana may decreased oxygen delivery to the myocardium because of elevated carboxyhemoglobin levels. This paper presents 3 cases in which, t...
Source: The Poison Review - June 25, 2014 Category: Toxicology Authors: Leon Tags: Medical cannabis cardiotoxicity coronary disease marijuana tetrahydrocannabinol THC Source Type: news

Using Drug-Intoxicated Deaths as Potential Organ Donors: Impression of Attendees at the American College of Medical Toxicology 2014 Annual Scientific Meeting.
CONCLUSIONS: Medical toxicologists have some reservation in recommending solid organs for transplantation from deaths from cocaine and carbon monoxide. Given the decrease in potential organ donors from typical methods of death, further work is needed to promote organ donation in deaths related to acute poisoning. PMID: 25023224 [PubMed - as supplied by publisher]
Source: Journal of Medical Toxicology - July 15, 2014 Category: Toxicology Authors: Wood DM, Chan WL, Dargan PI Tags: J Med Toxicol Source Type: research