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Should visceral fat be reduced to increase longevity?
Abstract Several epidemiologic studies have implicated visceral fat as a major risk factor for insulin resistance, type 2 diabetes mellitus, cardiovascular disease, stroke, metabolic syndrome and death. Utilizing novel models of visceral obesity, numerous studies have demonstrated that the relationship between visceral fat and longevity is causal while the accrual of subcutaneous fat does not appear to play an important role in the etiology of disease risk. Specific recommended intake levels vary based on a number of factors, including current weight, activity levels, and weight loss goals. It is discussed the nee...
Source: Ageing Research Reviews - June 10, 2013 Category: Genetics & Stem Cells Authors: Finelli C, Sommella L, Gioia S, La Sala N, Tarantino G Tags: Ageing Res Rev Source Type: research

Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome
Conclusions: Whole genome sequence analysis between the LH, LN, and LL strains identified the haplotype structure of these three strains and identified candidate genes with sequence variants predicted to affect gene function. This approach, merged with additional integrative genetics approaches, will likely lead to novel mechanisms underlying complex disease and provide new drug targets and therapies.
Source: BMC Genomics - Latest articles - March 14, 2014 Category: Genetics & Stem Cells Authors: Man MaSantosh AtanurTimothy AitmanAnne Kwitek Source Type: research

MicroRNAs Mediated MMP Regulation: Current Diagnostic and Therapeutic Strategies for Metabolic Syndrome.
Abstract Metabolic syndrome (MS) is a global socioeconomic problem rapidly progressing in accordance with increasing body mass index (BMI) and age. It is a consortium of risk factors, such as dyslipidaemia, insulin resistance, leptin resistance, reduced adiponectin, glucose intolerance, hyperglycemia, and hypertension. Collectively, these factors accelerate the onset of type 2 diabetes mellitus, cardiovascular disease, stroke, and certain cancers such as breast, liver pancreatic, and colon cancer. Extracellular matrix (ECM) and basement membrane remodeling play a central role during pathogenesis of MS as they regu...
Source: Current Gene Therapy - July 7, 2017 Category: Genetics & Stem Cells Authors: Saxena S, Jain A, Rani V Tags: Curr Gene Ther Source Type: research

Association of rs6921438 A < G with serum vascular endothelial growth factor concentrations in patients with metabolic syndrome.
CONCLUSION: Our findings show an association between a VEGF gene polymorphism with serum VEGF concentrations and dietary fat intake, but there was no association with the presence of MetS. PMID: 29733969 [PubMed - as supplied by publisher]
Source: Gene - May 4, 2018 Category: Genetics & Stem Cells Authors: Ghazizadeh H, Avan A, Fazilati M, Azimi-Nezhad M, Tayefi M, Ghasemi F, Mehramiz M, Moohebati M, Ebrahimi M, Mirhafez SR, Ferns GA, Esmaeili H, Pasdar A, Ghayour-Mobarhan M Tags: Gene Source Type: research

Association of a genetic variant in AKT1 gene with features of the metabolic syndrome
Publication date: Available online 17 June 2019Source: Genes & DiseasesAuthor(s): Fateme Sadat Eshaghi, Hamideh Ghazizadeh, Sakine Kazami Nooreini, Ameneh Timar, Habibollah Esmaeily, Mehrane Mehramiz, Amir Avan, Majid Ghayour-MobarhanAbstractMetabolic syndrome (MetS) is a clustering of metabolic abnormalities that is associated with increased risk of developing cardiovascular disease and type 2 diabetes. There is growing body of data showing the associations of genetic variants of the genes involved in the PI3K/AKT/mTOR pathway with diabetes and obesity. We aimed to investigate the association between MetS and its componen...
Source: Genes and Diseases - June 18, 2019 Category: Genetics & Stem Cells Source Type: research

A Haplotype of the ANGPTL3 gene is associated with CVD risk, diabetes mellitus, hypertension, obesity, metabolic syndrome, and dyslipidemia
CONCLUSION: We found that the GTC and CTC haplotypes of the ANGPTL3 gene may help identify individuals with a genetic susceptibility to cardiometabolic disorders.PMID:33636293 | DOI:10.1016/j.gene.2021.145525
Source: Gene - February 26, 2021 Category: Genetics & Stem Cells Authors: Malihe Aghasizadeh Reza Zare-Feyzabadi Tooba Kazemi Amir Avan Gordon A Ferns Habibollah Esmaily Ebrahim Miri-Moghaddam Majid Ghayour-Mobarhan Source Type: research