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Effects of switching from olanzapine, quetiapine, and risperidone to aripiprazole on 10-year coronary heart disease risk and metabolic syndrome status: Results from a randomized controlled trial
Conclusion: Switching from olanzapine, quetiapine, or risperidone to aripiprazole was associated with larger reductions in predicted 10-year risk of CHD than the behavioral program alone. The advantage of switching on metabolic syndrome was not statistically significant. The benefits of switching must be balanced against its risks, which in this study included more discontinuations of the study treatment but no significant increase in symptoms or hospitalizations.
Source: Schizophrenia Research - February 25, 2013 Category: Psychiatry Authors: T. Scott Stroup, Matthew J. Byerly, Henry A. Nasrallah, Neepa Ray, Ahsan Y. Khan, J. Steven Lamberti, Ira D. Glick, Richard M. Steinbook, Joseph P. McEvoy, Robert M. Hamer Tags: Neuropharmacology Source Type: research

Got Bipolar? You're at Risk for Metabolic Syndrome, Too
A study found that people with bipolar disorder are up to twice as likely as the general population to have metabolic syndrome, a cluster of symptoms that increase your risk of heart problems, stroke and diabetes. The study, published in the Journal of Affective Disorders, also found that "co-occurrence of metabolic syndrome in the bipolar population is associated with a more complex illness presentation, less favorable response to treatment, and adverse course and outcome." In other words, for people with bipolar disorder, both are likely to be more serious and harder to treat. Why are people with bipolar more likely to ...
Source: About.com Bipolar Disorder - June 3, 2013 Category: Psychiatry Source Type: news

The Metabolic Syndrome Predicts Longitudinal Changes in Clock Drawing Test Performance in Older Nondemented Hypertensive Individuals.
CONCLUSIONS: MetS as an entity predicted accelerated 1-year decline in cognitive function, assessed by CDT, in a sample of older hypertensive subjects. PMID: 26803584 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - January 25, 2016 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Metabolic Syndrome and Symptom Resolution in Depression: A 5-Year Follow-Up of Older Adults.
CONCLUSIONS: Low HDL cholesterol and high triglyceride levels are associated with lower likelihood of long-term symptom resolution in depression. These data suggest that an adverse lipid profile, but not other components of metabolic syndrome, may delay recovery from depression. PMID: 28129497 [PubMed - in process]
Source: Journal of Clinical Psychiatry - January 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Pre-Treatment Allostatic Load and Metabolic Dysregulation Predict Antidepressant Response in Major Depressive Disorder
Major depressive disorder (MDD) is associated with significant health risks, including increased rate of cardiovascular disease, stroke, and diabetes. Allostatic load (AL), a biological measure of cumulative stress, and metabolic dysregulation (MetD), a summary score of metabolic syndrome risk factors, are associated with increased disease burden and mortality risk. Though increased AL and MetD are well-established in MDD, no prior study has prospectively examined their relationship with antidepressant response.
Source: Biological Psychiatry - April 29, 2017 Category: Psychiatry Authors: Christina Hough, Alexandra Morford, Elissa Epel, Daniel Lindqvist, Francesco Saverio Bersani, Felipe Jain, Laura Mahan, Rebecca Rosser, Heather Burke, Synthia Mellon, Owen Wolkowitz, Victor Reus Source Type: research

Benefits of Antipsychotics Appear to Outweigh Risks, Experts Conclude
Despite recent concerns that long-term antipsychotic use adversely affects health outcomes —possibly by desensitizing dopamine receptors or through direct neurotoxic effects—areview article in AJP in Advance has concluded that the benefits of antipsychotics for the acute treatment of psychosis and the prevention of relapse largely outweigh the risks. Additionally, because delays in the treatment of psychosis and relapse have been associated with poorer outcomes, the review noted there may be risk associated with withholding or discontinuing medication.“Patients and their families should be made aware of the strong ev...
Source: Psychiatr News - May 8, 2017 Category: Psychiatry Tags: ajp in advance antipsychotics biomarkers diabetes dopamine receptors metabolic syndrome psychosis relapse schizophrenia stroke Source Type: research

1005. Pre-Treatment Allostatic Load and Metabolic Dysregulation Predict Antidepressant Response in Major Depressive Disorder
Major depressive disorder (MDD) is associated with significant health risks, including increased rate of cardiovascular disease, stroke, and diabetes. Allostatic load (AL), a biological measure of cumulative stress, and metabolic dysregulation (MetD), a summary score of metabolic syndrome risk factors, are associated with increased disease burden and mortality risk. Though increased AL and MetD are well-established in MDD, no prior study has prospectively examined their relationship with antidepressant response.
Source: Biological Psychiatry - May 11, 2017 Category: Psychiatry Authors: Christina Hough, Alexandra Morford, Elissa Epel, Daniel Lindqvist, Francesco Saverio Bersani, Felipe Jain, Laura Mahan, Rebecca Rosser, Heather Burke, Synthia Mellon, Owen Wolkowitz, Victor Reus Source Type: research

Metabolic Syndrome Predicts Poor Outcome in Acute Ischemic Stroke Patients After Endovascular Thrombectomy
Source: Neuropsychiatric Disease and Treatment - September 7, 2020 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank
CONCLUSIONS: This large study identified increased phenotypic cardiometabolic abnormalities in BPD participants. It is found that the comorbidity of coronary artery disease may be based on shared genetic aetiology. These results motivate hypothesis-driven research to consider individual cardiometabolic traits rather than a composite metabolic syndrome when attempting to disentangle driving mechanisms of cardiometabolic abnormalities in BPD.PMID:33766158 | DOI:10.1017/S0033291721000945
Source: Psychological Medicine - March 26, 2021 Category: Psychiatry Authors: Anna E F ürtjes Jonathan R I Coleman Jess Tyrrell Cathryn M Lewis Saskia P Hagenaars Source Type: research

Impact of Major Depressive Disorder on Comorbidities: A Systematic Literature Review
Conclusions: The presence of MDD was identified as a risk factor for both the development and the worsening of a range of comorbidities. These results highlight the importance of addressing depression early in its course and the need for integrating mental and general health care.PMID:36264099 | DOI:10.4088/JCP.21r14328
Source: Journal of Clinical Psychiatry - October 20, 2022 Category: Psychiatry Authors: Alix M Arnaud Teri S Brister Ken Duckworth Phyllis Foxworth Tonya Fulwider Ellison D Suthoff Brian Werneburg Izabela Aleksanderek Marcia L Reinhart Source Type: research

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