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Noncardiogenic Stroke Patients with Metabolic Syndrome Have More Border-zone Infarction and Intracranial Artery Stenosis
Little is known about the clinical character of stroke patients with metabolic syndrome (MetS) in Chinese population. In this hospital-based cross-sectional study, we elucidated the prevalence of MetS among patients with acute noncardiogenic cerebral infarction from south China, the topographic infarction patterns in magnetic resonance imaging, and vascular angiography findings of stroke patients with MetS.
Source: Journal of Stroke and Cerebrovascular Diseases - January 2, 2015 Category: Neurology Authors: Zheng Zhang, Meijuan Xiao, Zusen Ye, Wanli Zhang, Bin Han, Youcheng Li Source Type: research

Use of Total Cerebral Blood Flow as an Imaging Biomarker of Known Cardiovascular Risks Clinical Sciences
Conclusions— Reduced cerebral blood flow seems to be a correlate of vascular disease risk factors associated with cardiometabolic dysregulation. Cerebral blood flow may provide a valid imaging biomarker for cardiovascular risk.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Jennings, J. R., Heim, A. F., Kuan, D. C.-H., Gianaros, P. J., Muldoon, M. F., Manuck, S. B. Tags: Cerebrovascular disease/stroke, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

Biomarkers, Natural Course and Prognosis.
Authors: Arenillas JF, López-Cancio E, Wong KS Abstract Increasing our knowledge about intracranial atherosclerosis (ICAS) natural history and prognostic factors is essential to improve its preventive therapy and thus reduce the dramatic clinical consequences caused by this entity. ICAS is characterized by a chronic and progressive course until it becomes symptomatic, mostly through complication of an unstable intracranial atherosclerotic plaque. Population-based studies in healthy subjects have shown that the prevalence of asymptomatic ICAS is higher in Asian than in Caucasian populations. In both settings, asymp...
Source: Frontiers of Neurology and Neuroscience - December 15, 2016 Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research

Neuroimaging and Neurolaw: Drawing the Future of Aging
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, ...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research

Unilateral Symptomatic Intracranial Arterial Stenosis and Myopathy in an Adolescent with Graves Disease: A Case Report of an High-resolution Magnetic Resonance Imaging Study
Vascular and muscular involvements in Graves disease (GD) are rare. Here, we report a case of a 17-year-old patient with unilateral symptomatic middle cerebral artery stenosis concurrent with GD and myopathy. He presented with a 1-day history of acute severe right-sided hemiparesis and aphasia and a 3-week history of high metabolic syndrome. The pathogenesis of the stenosis is most likely vasculitis rather than atherosclerosis, based on contrast-enhanced high-resolution magnetic resonance imaging showing concentric wall enhancement.
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2014 Category: Neurology Authors: Jia Yin, Jiajia Zhu, Dongling Huang, Changzheng Shi, Yuqing Guan, Liang Zhou, Suyue Pan Tags: Case Report Source Type: research

Obesity, Insulin Resistance, and Incident Small Vessel Disease on Magnetic Resonance Imaging: Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— The IR score and central obesity are associated with incident lacunar disease but not WMH progression in individuals. Central obesity and IR may be important risk factors to target to prevent lacunar disease.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Dearborn, J. L., Schneider, A. L. C., Sharrett, A. R., Mosley, T. H., Bezerra, D. C., Knopman, D. S., Selvin, E., Jack, C. R., Coker, L. H., Alonso, A., Wagenknecht, L. E., Windham, B. G., Gottesman, R. F. Tags: Glucose intolerance, CT and MRI, Cerebral Lacunes, Epidemiology Clinical Sciences Source Type: research

The Metabolic Syndrome Predicts Longitudinal Changes in Clock Drawing Test Performance in Older Nondemented Hypertensive Individuals.
CONCLUSIONS: MetS as an entity predicted accelerated 1-year decline in cognitive function, assessed by CDT, in a sample of older hypertensive subjects. PMID: 26803584 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - January 25, 2016 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Carotid Plaque Lipid Content and Fibrous Cap Status Predict Systemic CV Outcomes: The MRI Substudy in AIM-HIGH
Conclusions Among patients with clinically established atherosclerotic disease, carotid plaque lipid content and fibrous cap status were strongly associated with systemic cardiovascular outcomes. Markers of carotid plaque vulnerability may serve as novel surrogate markers for systemic atherothrombotic risk.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - March 5, 2017 Category: Radiology Authors: Sun, J., Zhao, X.-Q., Balu, N., Neradilek, M. B., Isquith, D. A., Yamada, K., Canton, G., Crouse, J. R., Anderson, T. J., Huston, J., OBrien, K., Hippe, D. S., Polissar, N. L., Yuan, C., Hatsukami, T. S. Tags: Original Research Source Type: research

Relationship Between Asymptomatic Intracranial Stenosis and Extracranial Arteriosclerotic Findings in Workplace Health Checkups: A Pilot Study
Background: Intracranial arteriosclerotic disease (ICAD) is common in Asians and has been presumed to be largely associated with metabolic syndrome (MetS), but the risks for asymptomatic ICAD detectable in examinations of the brain, among other tests, are not well known. The present study is aimed at identifying the risks for asymptomatic ICAD using data on risk factors obtained in health checkups, including data from magnetic resonance imaging (MRI), chest computed tomography (CT), and neck echography.
Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2019 Category: Neurology Authors: Makoto Shiraishi, Yasuhiro Hasegawa, Nobuyoshi Narita, Hitoshi Miyake Source Type: research

Sex-specific association of metabolic risk factors with brain ischemic lesions by severity and location
ConclusionsMetabolic syndrome was associated with brain ischemic lesions in men but not in women. Higher body mass index was related to ischemic lesions located in lobar in men and in deep brain/infratentorial areas in women. Its mechanisms remain to be further investigated.
Source: Biology of Sex Differences - August 21, 2019 Category: Biology Source Type: research