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The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health
Korean Circ J. 2023 Jun 23. doi: 10.4070/kcj.2023.0048. Online ahead of print.ABSTRACTCardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% of deaths worldwide. Although the risk factors of CVDs have been well understood and various treatment and preventive measures have been established, the mortality rate and the financial burden of CVDs are expected to grow exponentially over time due to the changes in lifestyles and increasing life expectancies of the present generation. Recent advancements in meta...
Source: Korean Circulation Journal - August 1, 2023 Category: Cardiology Authors: Thi Van Anh Bui Hyesoo Hwangbo Yimin Lai Seok Beom Hong Yeon-Jik Choi Hun-Jun Park Kiwon Ban Source Type: research

Functional Insufficiency of Mitral and Tricuspid Valves Associated With Atrial Fibrillation: Impact of Postoperative Atrial Fibrillation Recurrence on Surgical Outcomes
CONCLUSION: Among patients undergoing surgery for functional atrioventricular insufficiency associated with AF, a significant proportion showed recurrence of AF over time after concomitant AF ablation, which was significantly associated with poor clinical outcomes.PMID:37525492 | DOI:10.4070/kcj.2022.0355
Source: Korean Circulation Journal - August 1, 2023 Category: Cardiology Authors: Kitae Kim Ho Jin Kim Sung-Ho Jung JaeWon Lee Joon Bum Kim Source Type: research

The Gut-Heart Axis: Updated Review for The Roles of Microbiome in Cardiovascular Health
Korean Circ J. 2023 Aug;53(8):499-518. doi: 10.4070/kcj.2023.0048. Epub 2023 Jun 23.ABSTRACTCardiovascular diseases (CVDs), including coronary artery disease, stroke, heart failure, and hypertension, are the global leading causes of death, accounting for more than 30% of deaths worldwide. Although the risk factors of CVDs have been well understood and various treatment and preventive measures have been established, the mortality rate and the financial burden of CVDs are expected to grow exponentially over time due to the changes in lifestyles and increasing life expectancies of the present generation. Recent advancements i...
Source: Korean Circulation Journal - August 1, 2023 Category: Cardiology Authors: Thi Van Anh Bui Hyesoo Hwangbo Yimin Lai Seok Beom Hong Yeon-Jik Choi Hun-Jun Park Kiwon Ban Source Type: research

Plasma TSH and cardiovascular risk in the general population
Background and Aims: The association between thyroid stimulating hormone (TSH) and cardiovascular disease has mainly been determined using clinical categories of disease. We tested the hypothesis that TSH on a continuous scale is associated with risk of atrial fibrillation (AF), myocardial infarction (MI), stroke, heart failure (HF), aortic valve stenosis (AVS), and major adverse cardiovascular events (MACE) and whether these associations are likely to be causal.
Source: Atherosclerosis - August 1, 2023 Category: Cardiology Authors: N. Dalila, R. Frikke-Schmidt, B. Nordestgaard, A. Tybjaerg-Hansen Source Type: research

Bedtime versus morning use of antihypertensives in frail continuing care residents (BedMed-Frail): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial
Introduction BedMed-Frail explores risks and benefits of switching antihypertensives from morning to bedtime in a frail population at greater risk of hypotensive adverse effects. Methods and analysis Design: Prospective parallel randomised, open-label, blinded end-point trial. Participants: Hypertensive continuing care residents, in either long-term care or supportive living, who are free from glaucoma, and using ≥1 once daily antihypertensive. Setting: 16 volunteer continuing care facilities in Alberta, Canada, with eligible residents identified using electronic health claims data. Intervention: All non-opted out elig...
Source: BMJ Open - August 1, 2023 Category: General Medicine Authors: Garrison, S. R., Youngson, E., Perry, D. A., Campbell, F. N., Kolber, M. R., Korownyk, C., Allan, G. M., Green, L., Bakal, J. Tags: Open access, Cardiovascular medicine Source Type: research

Inflammation and immunomodulatory therapies influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid arthritis
CONCLUSION: ABCA1-CEC associated with decreased atherosclerosis in patients with below-median baseline and time-averaged CRP and bDMARD use. Conversely, ABCA1-CEC associated with increased plaque in those with higher CRP, corticosteroid users, methotrexate nonusers, and bDMARD nonusers. While in well-treated and controlled disease ABCA1-CEC appears atheroprotective, in uncontrolled RA its action may be masked or fail to counteract the inflammation-driven proatherogenic state.PMID:37520890 | PMC:PMC10371792 | DOI:10.1016/j.jtauto.2023.100209
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: George A Karpouzas Bianca Papotti Sarah R Ormseth Marcella Palumbo Elizabeth Hernandez Maria Pia Adorni Francesca Zimetti Matthew J Budoff Nicoletta Ronda Source Type: research

Real ‐world risk of cardiovascular diseases in patients with type 2 diabetes associated with sodium–glucose cotransporter 2 inhibitors in comparison with metformin: A propensity score‐matched model analysis in Japan
Risk of CVD using SGLT2Is compared with metformin. AbstractWe aimed to compare the effects of cardiovascular disease risk in Japanese patients with type 2 diabetes on sodium–glucose cotransporter 2 inhibitors (SGLT2Is) or metformin. This retrospective, real-world cohort study was carried out using a claims database and propensity score matching; 58,402 eligible patients (29,201 per group) were included. The outcomes included nonfatal myocardi al infarction, angina pectoris, nonfatal stroke, hospitalization for heart failure and composite end-points. The hazard ratio (HR) for the composite end-point was 0.79, which w...
Source: Journal of Diabetes Investigation - July 31, 2023 Category: Endocrinology Authors: Takeshi Horii, Yoichi Oikawa, Akira Shimada, Kiyoshi Mihara Tags: SHORT REPORT Source Type: research

A higher probability of subsequent stroke and ischemic heart disease in migraine patients: a longitudinal follow-up study in Korea
ConclusionsOur longitudinal follow-up study demonstrated a significant association between the presence of migraine and the development of stroke and ischemic heart disease in Korea, even after adjusting for cardiovascular risk factors.
Source: The Journal of Headache and Pain - July 31, 2023 Category: Neurology Source Type: research

Subjective Gait Speed and Risk of Developing Cardiovascular Events in 56,589 Cancer Survivors
Int Heart J. 2023;64(4):672-677. doi: 10.1536/ihj.22-728.ABSTRACTDespite having a higher risk of cardiovascular disease (CVD), there are currently limited data for stratifying CVD risk among cancer survivors. The purpose of this study was to uncover the relationship of subjective gait speed with incident CVD among cancer survivors.This retrospective observational cohort study analyzed data from the JMDC Claims Database between 2005 and 2021 including 56,589 patients with a prior history of breast, colorectal, or stomach cancer but no history of CVD. Gait speed was evaluated using information from self-reported questionnair...
Source: International Heart Journal - July 30, 2023 Category: Cardiology Authors: Ryusei Ohno Hidehiro Kaneko Kensuke Ueno Kentaro Kamiya Akira Okada Yuta Suzuki Satoshi Matsuoka Katsuhito Fujiu Nobuaki Michihata Taisuke Jo Norifumi Takeda Hiroyuki Morita Koichi Node Hideo Yasunaga Issei Komuro Source Type: research

The Prognostic Implications of Living Alone on Long-Term Mortality in Patients with Chronic Coronary Syndrome after Percutaneous Coronary Intervention
Int Heart J. 2023;64(4):584-589. doi: 10.1536/ihj.23-063.ABSTRACTLiving alone is associated with increased cardiac events and mortality in patients with acute myocardial infarction. However, the prognostic impact of living alone with chronic coronary syndrome (CCS) still remains unclear. In the present study, we examined the relationship between living alone and long-term mortality in patients with CCS who underwent percutaneous coronary intervention (PCI).Consecutive 830 patients with CCS who underwent PCI were enrolled and divided into 2 groups according to whether or not they were living alone at the time of admission (...
Source: International Heart Journal - July 30, 2023 Category: Cardiology Authors: Daisuke Isomatsu Akihiko Sato Yuya Sakuma Yuta Kurosawa Yuki Muto Yu Sato Takatoyo Kiko Takeshi Shimizu Tomofumi Misaka Akiomi Yoshihisa Takayoshi Yamaki Kazuhiko Nakazato Takafumi Ishida Yasuchika Takeishi Source Type: research

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