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Condition: Concussion

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Total 172 results found since Jan 2013.

Clinical results in brain injury trials using HBO2 therapy: Another perspective.
Abstract The current debate surrounding the use of hyperbaric oxygen (HBO2) for neurological indications, specifically mild to moderate chronic traumatic brain injury (mTBI) and post-concussion syndrome (PCS), is mired in confusion due to the use of non-validated controls and an unfamiliarity by many practitioners of HBO2 therapy with the experimental literature. In the past 40 years, the use of an air sham (21% oxygen, 1.14-1.5 atmospheres absolute/atm abs) in clinical and animal studies, instead of observational or crossover controls, has led to false acceptance of the null hypothesis (declaring no effect when o...
Source: Undersea and Hyperbaric Medicine - July 1, 2015 Category: Sports Medicine Authors: Figueroa XA, Wright JK Tags: Undersea Hyperb Med Source Type: research

Brainlab invests nearly $8m into Jan Medical
Jan Medical said today it obtained $7.5 million in Series C funding from partner Brainlab Inc, with funds slated to aid in completion of a clinical trial and filing for de novo clearance with the FDA and CE Mark approval in the European Union for its BrainPulse tool. Mountain View, Calif.-based Jan Medical’s BrainPulse device is designed to non-invasively capture novel physiological signals through a patient’s cardiac output, used to measure vascular and brain tissue conditions, the company said. The data can be used as an ‘aid to diagnoses’ for multiple indications, including concussion and stro...
Source: Mass Device - January 25, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Cardiovascular Diagnostics Regulatory/Compliance Brainlab Jan Medical Source Type: news

Jan Medical raises $7.5M for diagnostic tool that detects neurological conditions
Mountain View, California-based Jan Medical has raised $7.5 million from Germany-based Brainlab to develop a connected diagnostic device that helps detect abnormal neurological conditions, like concussion and stroke. Jan Medical has raised at least $10.6 million in total to date.
Source: mobihealthnews - January 25, 2016 Category: Information Technology Source Type: news

Can concussion be tested for with a 'simple' blood test?
Conclusion This study is a prospective cohort study that aimed to investigate the use of two proteins in the blood – GFAP and UCH-L1 – as markers for detecting mild to moderate traumatic brain injury. The study found both proteins could be present in the blood after a head injury, with higher levels of UCH-L1 in the early stages after injury, while GFAP seemed to be a good marker for up to a week after injury. But both biomarkers were not found in all cases. One in five people with a brain injury did not have detectable levels of GFAP, and 1 in 10 did not have UCH-L1. This substantially reduces their ability to be us...
Source: NHS News Feed - March 29, 2016 Category: Consumer Health News Tags: Medical practice Neurology Source Type: news

Mood symptoms correlate with kynurenine pathway metabolites following sports-related concussion
Conclusions These results converge with existing kynurenine literature on psychiatric patients and provide the first evidence of altered peripheral levels of kynurenine metabolites following sports-related concussion.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 12, 2016 Category: Neurosurgery Authors: Singh, R., Savitz, J., Teague, T. K., Polanski, D. W., Mayer, A. R., Bellgowan, P. S. F., Meier, T. B. Tags: Stroke, Mood disorders (including depression) Neuropsychiatry Source Type: research

Your NEJM Group Today: Cryptogenic Stroke Case, Kids' Concussion in Primary Care, New York Hospitalist Opportunity (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical Practice Center: Clinical Practice: After a gym workout, a …
Source: Physician's First Watch current issue - May 31, 2016 Category: Primary Care Source Type: news

Acute Ataxia in Childhood: 11-Year Experience at a Major Pediatric Neurology Referral Center
We categorized the causes of acute ataxia in the pediatric population—referred to the Division of Neurology—at a large, urban pediatric medical center. Of the 120 cases identified over the past 11 years, post-infectious cerebellar ataxia was the most commonly diagnosed (59%), followed by drug intoxication, opsoclonus-myoclonus ataxia syndrome, episodic ataxia, acute cerebellitis, cerebellar stroke, ADEM, meningitis, cerebral vein thrombosis, Leigh’s disease, Miller-Fisher syndrome, and concussion. Among the patients with post-infectious cerebellar ataxia, 85% were 1–6 years old and all had a history...
Source: Journal of Child Neurology - July 11, 2016 Category: Neurology Authors: Thakkar, K., Maricich, S. M., Alper, G. Tags: Original Articles Source Type: research

Getting Inside the Athlete ’s Brain
Joyce Laird Dr. Jeffrey Kutcher takes neurology to the playing field. One of the things Kutcher has been teaching for years is concussion as a network injury. When we talk of localizing things in the brain one of the first things we do is try to describe whether it is a focal process like a stroke, a multi-focal process like MS, or is it a diffused process; something that affects the neurons or blood vessels in the brain in a very general way. read more
Source: Articles from MedicalDesign.com - October 7, 2014 Category: Medical Equipment Tags: Electronics Neurotechnology Source Type: news

MRI scan may help diagnose chronic traumatic encephalopathy, UCLA researchers report
UCLA doctors have found what may be an earlier and easier way to diagnose chronic traumatic encephalopathy, or CTE, a disorder that is thought to affect some former football players and others with a history of repetitive brain trauma. Using a new software tool for analyzing MRI scans, the researchers detected the shrinkage of several key brain regions in a former football player with cognitive problems. The same pattern of brain changes is commonly seen in CTE cases that have been confirmed by autopsies after a person’s death. While the findings from this single case report are preliminary, they raise the possibility th...
Source: UCLA Newsroom: Health Sciences - August 24, 2016 Category: Universities & Medical Training Source Type: news

Concussion research at the National Institutes of Health: an update from the National Institute of Neurological Disorders and Stroke - Mott M, Koroshetz W.
[Abstract unavailable] Language: en...
Source: SafetyLit - October 6, 2016 Category: Global & Universal Tags: Commentary Source Type: news

A Woman's Place is at the Table
As I watched Donald Trump pace behind Hillary Clinton during the second presidential debate, I noticed myself growing increasingly uncomfortable. At the time, I attributed my discomfort to the generalized anxiety accompanying this particularly contentious election cycle. It was only when I saw the Saturday Night Live parody of that debate that I realized what had truly spooked me. It was the way Alec Baldwin, playing Donald Trump, lurked menacingly behind Kate McKinnon, playing Hillary Clinton, throughout the event. It was on his final swerve across the frame, to the soundtrack of Jaws, that I understood the source of my d...
Source: Healthy Living - The Huffington Post - November 2, 2016 Category: Consumer Health News Source Type: news

Mapping Traumatic Brain Injuries
There's been an increasing amount of media attention to the topic of Traumatic Brain Injury (TBI) -bolstered in part by conversations surrounding the 2015 Hollywood blockbuster Concussion. The movie Concussion describes a particular phenomenon, Chronic Traumatic Encephalopathy or CTE, which occurs in the brain after repeated high impact blows to the head. The diagnosis of CTE requires examining brain tissue under a microscope after death, so it can't be diagnosed in living individuals. But in fact, there are many types of TBI, with concussion being the mildest (but most common) form. Today, brain mapping techniques are mak...
Source: Science - The Huffington Post - January 17, 2017 Category: Science Source Type: news

Head injuries can alter hundreds of genes and lead to serious brain diseases, UCLA biologists report
Head injuries can harm hundreds of genes in the brain in a way that increases people ’s risk for a wide range of neurological and psychiatric disorders, UCLA life scientists report.The researchers identified for the first time master genes that they believe control hundreds of other genes which are linked to Alzheimer ’s disease, Parkinson’s disease, post-traumatic stress disorder, stroke, attention deficit hyperactivity disorder, autism, depression, schizophrenia and other disorders.Knowing what the master genes are could give scientists targets for new pharmaceuticals to treat brain diseases. Eventually, scientists...
Source: UCLA Newsroom: Health Sciences - March 6, 2017 Category: Universities & Medical Training Source Type: news

Characterization of pain and fatigue following deployment-related mild traumatic brain injury (P5.149)
Conclusions:This exploratory analysis suggests that severity of headache pain and degree of fatigue are interrelated following mTBI, and the most prominent dimensions of fatigue are general, mental and reduced activity, rather than reduced motivation.Study Supported by:National Institute of Neurological Disorders and Stroke Clinical Neuroscience ProgramDisclosure: Dr. Lewis has nothing to disclose. Dr. Knutson has nothing to disclose. Dr. Wassermann has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lewis, J., Knutson, K., Wassermann, E. Tags: Clinical Neuro-rehabilitation Source Type: research

The Clinical and Neuropathological Correlates of Second-Impact Syndrome: Case Report of a 17-year-old Female Rugby Player (P6.164)
Conclusions:This is the first case study to report the clinical and neuropathological features of SIS. Larger autopsy samples are needed to systematically identify clinicopathological correlates of SIS to facilitate research on risk factors and preventative strategies (e.g., return-to-play guidelines) to prevent unnecessary fatalities in young athletes.Study Supported by: This work was supported by the National Institute of Neurological Disorders and Stroke (1U01NS086659-01, U01NS093334, R01NS078337, R56NS078337), Department of Defense (W81XWH-13-2-0064), Department of Veterans Affairs, the Veterans Affairs Biorepository (...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Mian, M., Alosco, M., Mez, J., Kiernan, P., Daneshvar, D., Nowinski, C., Kowall, N., Stern, R., Katz, D., Cantu, R., McKee, A. Tags: Neuro Trauma and Sports Neurology II Source Type: research