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Condition: Hypertrophic Cardiomyopathy

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Total 437 results found since Jan 2013.

Prognostic Implications of Left Ventricular Scar Determined by Late Gadolinium Enhanced Cardiac Magnetic Resonance in Patients with Atrial Fibrillation
Left ventricular (LV) scar identified by late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) is associated with adverse outcomes in coronary artery disease (CAD) and cardiomyopathies. We sought to determine the prognostic significance of LV-LGE in atrial fibrillation (AF). We studied 778 consecutive patients referred for radiofrequency ablation of AF who underwent CMR. Patients with CAD, prior myocardial infarction (MI), or hypertrophic or dilated cardiomyopathy were excluded. The endpoints of interest were major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of cardiovascular death,...
Source: The American Journal of Cardiology - July 17, 2016 Category: Cardiology Authors: Promporn Suksaranjit, Christopher J. McGann, Nazem Akoum, Joseph Biskupiak, Gregory J. Stoddard, Eugene G. Kholmovski, Leenhapong Navaravong, Allen Rassa, Erik Bieging, Lowell Chang, Imran Haider, Nassir F. Marrouche, Brent D. Wilson Source Type: research

Usefulness of Electrocardiographic Patterns at Presentation to Predict Long-term Risk of Cardiac Death in Patients With Hypertrophic Cardiomyopathy
The objective of this study was to investigate the prognostic significance of 12-lead electrocardiogram (ECG) patterns in a large multicenter cohort of patients with hypertrophic cardiomyopathy; 1,004 consecutive patients with hypertrophic cardiomyopathy and a recorded standard ECG (64% men, mean age 50 ± 16 years) were evaluated at 4 Italian centers. The study end points were sudden cardiac death (SCD) or surrogates, including appropriate implanted cardiac defibrillator discharge and resuscitated cardiac arrest and major cardiovascular events (including SCD or surrogates and death due to heart f ailure, cardioembolic st...
Source: The American Journal of Cardiology - May 14, 2016 Category: Cardiology Authors: Elena Biagini, Chiara Pazzi, Iacopo Olivotto, Beatrice Musumeci, Giuseppe Limongelli, Giuseppe Boriani, Giuseppe Pacileo, Vittoria Mastromarino, Maria Letizia Bacchi Reggiani, Massimiliano Lorenzini, Francesco Lai, Alessandra Berardini, Francesca Mingardi Tags: Cardiomyopathy Source Type: research

Subclinical Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM), with a reported prevalence of AF in HCM of about 25 %.1 Patients with AF in HCM tend to be more symptomatic and have an increased stroke risk compared with patients without HCM.2 While the occurrence and treatment of (symptomatic) AF in HCM have been extensively studied, there is little data on the significance, prevalence, and management of subclinical AF in HCM.
Source: Radcliffe Cardiology - August 19, 2016 Category: Cardiology Authors: mehul Source Type: research

Genetic Screening of Anderson-Fabry Disease in Probands Referred From Multispecialty Clinics
ConclusionsScreening probands with clinically suspected AFD significantly increased diagnostic yield. The heart was  the organ most commonly involved, independent of the clinical setting in which the patient was first evaluated.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - August 29, 2016 Category: Radiology Source Type: research

Catheter ablation for atrial fibrillation in hypertrophic cardiomyopathy: a systematic review and meta-analysis
Conclusions The observed complication rate of catheter ablation of AF in patients with HCM was low. Even though the risk of relapse is twofold higher, catheter ablation can be effective in patients with HCM and AF, particularly in patients with paroxysmal AF and smaller atria.
Source: Heart - September 12, 2016 Category: Cardiology Authors: Providencia, R., Elliott, P., Patel, K., McCready, J., Babu, G., Srinivasan, N., Bronis, K., Papageorgiou, N., Chow, A., Rowland, E., Lowe, M., Segal, O. R., Lambiase, P. D. Tags: Tachyarrhythmias, Editor's choice, Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Clinical diagnostic tests Heart failure and cardiomyopathy Source Type: research

Role of quantitative myocardial positron emission tomography for risk stratification in patients with hypertrophic cardiomyopathy: a 2016 reappraisal
ConclusionsDip-MBF confirms its role as potent predictor of outcome in HCM. However, the threshold for prediction in a contemporary cohort is higher than that reported in earlier studies. Dip-MBF impairment in the lateral wall, possibly reflecting diffuse disease extending to non-hypertrophic regions, is a sensitive predictor of mortality in HCM.
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 3, 2016 Category: Nuclear Medicine Source Type: research

N ‐terminal pro‐brain natriuretic peptide is a useful marker to identify latent heart failure patients in older adults in a rural outpatient clinic
ConclusionsA large number of elderly patients without a diagnosis of HF who were attending an outpatient clinic showed high levels of NT‐proBNP, and measurement of NT‐proBNP is useful to identify patients with latent HF. Geriatr Gerontol Int 2016; ••: ••–••.
Source: Geriatrics and Gerontology International - October 31, 2016 Category: Geriatrics Authors: Kosuke Hamagawa, Toru Kubo, Kotaro Nishimura, Yuichi Baba, Takayoshi Hirota, Naohito Yamasaki, Hiroaki Kitaoka Tags: Original Article: Epidemiology, Clinical Practice and Health Source Type: research

Subclinical Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy
Atrial fibrillation (AF) is the most common arrhythmia in patients with hypertrophic cardiomyopathy (HCM), with a reported prevalence of AF in HCM of about 25 %.1 Patients with AF in HCM tend to be more symptomatic and have an increased stroke risk compared with patients without HCM.2 While the occurrence and treatment of (symptomatic) AF in HCM have been extensively studied, there is little data on the significance, prevalence, and management of subclinical AF in HCM.
Source: Radcliffe Cardiology - August 19, 2016 Category: Cardiology Authors: mehul Source Type: research

Relationship between aetiology and left ventricular systolic dysfunction in hypertrophic cardiomyopathy
Conclusions In adults with HCM, LV systolic dysfunction is more frequent in those with rare phenocopies. When combined with age at presentation, it is a marker for specific aetiologies and is associated with poorer long-term survival.
Source: Heart - January 26, 2017 Category: Cardiology Authors: Rosmini, S., Biagini, E., O'Mahony, C., Bulluck, H., Ruozi, N., Lopes, L. R., Guttmann, O., Reant, P., Quarta, C. C., Pantazis, A., Tome-Esteban, M., Mckenna, W. J., Rapezzi, C., Elliott, P. M. Tags: Hypertrophic cardiomyopathy, Drugs: cardiovascular system, Echocardiography, Interventional cardiology, Clinical diagnostic tests, Epidemiology, Metabolic disorders Heart failure and cardiomyopathies Source Type: research

Occurrence and Natural History of Clinically Silent Episodes of Atrial Fibrillation in Hypertrophic Cardiomyopathy
Overt symptomatic atrial fibrillation (AF) occurs in over 20% of hypertrophic cardiomyopathy (HC) patients leading to impaired quality of life, loss of productivity, and the risk for embolic stroke. However, the overall burden presented by AF in the HC population is unresolved due to the unknown frequency of silent asymptomatic episodes that do not necessarily achieve clinical recognition, but nevertheless may have important disease-related implications. Therefore, stored electrograms were analyzed retrospectively for AF in 75 consecutive HC patients (without prior AF history) implanted with dual chamber cardioverter-defibrillators (ICD).
Source: The American Journal of Cardiology - March 14, 2017 Category: Cardiology Authors: Ethan J. Rowin, Alexander Orfanos, Mark Estes, Wendy Wang, Mark S. Link, Martin S. Maron, Barry J. Maron Source Type: research

Fabry Disease in Families With Hypertrophic Cardiomyopathy: Clinical Manifestations in the Classic and Later-Onset Phenotypes Original Articles
Conclusions— Men with classic or later-onset FD caused by GLA missense mutations developed prominent and similar cardiovascular disease at similar ages, despite markedly different α-GalA activities.
Source: Circulation: Cardiovascular Genetics - August 10, 2017 Category: Cardiology Authors: Adalsteinsdottir, B., Palsson, R., Desnick, R. J., Gardarsdottir, M., Teekakirikul, P., Maron, M., Appelbaum, E., Neisius, U., Maron, B. J., Burke, M. A., Chen, B., Pagant, S., Madsen, C. V., Danielsen, R., Arngrimsson, R., Feldt-Rasmussen, U., Seidman, J Tags: Genetics, Cardiomyopathy, Hypertrophy Original Articles Source Type: research

Outcomes of Berlin Heart EXCOR ® pediatric ventricular assist device support in patients with restrictive and hypertrophic cardiomyopathy
This study reviews the North American experience with Berlin Heart EXCOR® ventricular assist device implants in children with such physiology. The Berlin Heart clinical database was reviewed. Patients with primary diastolic dysfunction are included in this study. Twenty pediatric patients with restrictive cardiomyopathy (n = 13), hypertrophic cardiomyopathy (n = 3), or congenital heart disease with restrictive physiology (n = 4) who were supported with EXCOR® were identified. Of these, nine (45%) were successfully bridged to transplant, one (5%) weaned from support, and 10 (50%) died after support was withdrawn. Of...
Source: Pediatric Transplantation - September 1, 2017 Category: Transplant Surgery Authors: Jennifer A. Su, Jondavid Menteer Tags: ORIGINAL ARTICLE Source Type: research

How amazing is a maze procedure in the obstructive hypertrophic cardiomyopathy population?
Hypertrophic cardiomyopathy (HCM) is among the most common genetic cardiac diseases, affecting approximately 1 in 500 individuals.1 Prevention of atrial fibrillation (AF) in patients with HCM carries significant clinical importance, inasmuch as the combination of HCM and AF is a class I indication for anticoagulation and is associated with increased risk of heart failure-related mortality, stroke, and severe functional disability.2 Although the maze procedure has been shown to reduce the risk of AF with a success rate of ∼95% among patients without HCM,3 the procedure can pose a unique challenge due to hypertrophy of atr...
Source: The Journal of Thoracic and Cardiovascular Surgery - September 11, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Yuichi J. Shimada, Shepard D. Weiner, Hiroo Takayama Tags: Editorial commentary Source Type: research

{alpha}-Galactosidase A Genotype N215S Induces a Specific Cardiac Variant of Fabry Disease Original Articles
Conclusions— α-Galactosidase A genotype N215S does not lead to the development of a classical Fabry phenotype but induces a specific cardiac variant of Fabry disease mimicking nonobstructive hypertrophic cardiomyopathy. The lack of prominent noncardiac impairment leads to a significant delay in diagnosis and Fabry-specific therapy.
Source: Circulation: Cardiovascular Genetics - October 10, 2017 Category: Cardiology Authors: Oder, D., Liu, D., Hu, K., Uceyler, N., Salinger, T., Muntze, J., Lorenz, K., Kandolf, R., Grone, H.-J., Sommer, C., Ertl, G., Wanner, C., Nordbeck, P. Tags: Nephrology and Kidney, Genetics, Cardiomyopathy, Hypertrophy, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Long ‐term outcomes for different surgical strategies to treat left ventricular outflow tract obstruction in hypertrophic cardiomyopathy
ConclusionSeptal myectomy is a safe procedure resulting in symptomatic improvement in the majority of patients. The annual incidence of non‐fatal disease‐related complications after surgical treatment of LVOTO is relatively high. Patients who underwent MV replacements had poorer outcomes with less symptomatic benefit in spite of a similar reduction in LVOT gradients.
Source: European Journal of Heart Failure - November 16, 2017 Category: Cardiology Authors: Richard Collis, Oliver Watkinson, Constantinos O'Mahony, Oliver P. Guttmann, Antonis Pantazis, Maria Tome ‐Esteban, Victor Tsang, Venkatachalam Chandrasekaran, Christopher G.A. McGregor, Perry M. Elliott Tags: Research Article Source Type: research