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Condition: Hypertrophic Cardiomyopathy

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Total 437 results found since Jan 2013.

Temporal trends of hypertrophic cardiomyopathy in Denmark: a nationwide retrospective cohort study
Conclusion There was a consistent rise in HCM cases with decreasing morbidity burden. Females were older at diagnosis and more likely to have their type of HCM classified as obstructive. The rate of outpatient follow-up is increasing.
Source: BMJ Open - September 4, 2023 Category: General Medicine Authors: Zörner, C. R., Pallisgaard, J., Schjerning, A.-M., Jensen, M. K., Tonnesen, J., Da Riis-Vestergaard, L., Middelfart, C., Rasmussen, P. V., Gislason, G., Hansen, M. L. Tags: Open access, Cardiovascular medicine Source Type: research

State-of-the-Art Review: Alcohol Septal Ablation in Hypertrophic Cardiomyopathy
The objective of this review is to provide the reader with a synopsis of percutaneous alcohol septal ablation (ASA) as an effective and time-honored treatment modality in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM).Recent findingsPatients who have medically refractory symptoms of dynamic left ventricular outflow tract obstruction may benefit from septal reduction therapy including septal myectomy or ASA. ASA involves infusion of alcohol into an epicardial septal artery supplying the basal septum to generate an iatrogenic infarction and, thus, reduce outflow tract obstruction due to targeted hypo...
Source: Current Treatment Options in Cardiovascular Medicine - August 21, 2023 Category: Cardiology Source Type: research

Signaling Pathways Associated with Prior Cardiovascular Events in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. A subset of patients experience major adverse cardiovascular event (MACE) including arrhythmias, stroke, and heart failure. However, molecular mechanisms underlying MACE in HCM are still not well understood. We therefore conducted a multicenter case-control study of patients with HCM comparing those with and without prior history of MACE to identify dysregulated signaling pathways through plasma proteomics profiling.
Source: Journal of Cardiac Failure - August 7, 2023 Category: Cardiology Authors: Charlotte Lee, Lusha W. Liang, Kohei Hasegawa, Mathew S. Maurer, Albree Tower-Rader, Michael A. Fifer, Muredach Reilly, Yuichi J. Shimada Source Type: research

The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis
Curr Opin Lipidol. 2023 Jul 28. doi: 10.1097/MOL.0000000000000890. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To explore the multiple roles that lysophosphatidic acid (LPA) plays in vascular disease and atherosclerosis.RECENT FINDINGS: A high-fat high-cholesterol diet decreases antimicrobial activity in the small intestine, which leads to increased levels of bacterial lipopolysaccharide in the mucus of the small intestine and in plasma that increase systemic inflammation, and enhance dyslipidemia and aortic atherosclerosis. Decreasing LPA production in enterocytes reduces the impact of the diet. LPA signaling inhibit...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: Arnab Chattopadhyay Srinivasa T Reddy Alan M Fogelman Source Type: research

Left ventricular strain and myocardial work in apical hypertrophic cardiomyopathy
CONCLUSIONS: ApHCM is associated with preserved LV ejection fraction but abnormal LV GLS and work indices, with progressive impairment. Important clinical and echocardiographic measures are independently predictive of long-term follow-up LV GLS, GWI and adverse events.PMID:37426133 | PMC:PMC10323562 | DOI:10.21037/jtd-23-202
Source: Journal of Thoracic Disease - July 10, 2023 Category: Respiratory Medicine Authors: Christos G Mihos Sofia A Horvath Rafle Fernandez Esteban Escolar Source Type: research