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Condition: Ischemic Stroke
Nutrition: Zinc
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Total 55 results found since Jan 2013.
A review on the role of ZEB1-AS1 in human disorders
Pathol Res Pract. 2023 Apr 26;245:154486. doi: 10.1016/j.prp.2023.154486. Online ahead of print.ABSTRACTZEB1 Antisense RNA 1 (ZEB1-AS1) is a type of RNA characterized as long non-coding RNA (lncRNA). This lncRNA has important regulatory roles on its related gene, Zinc Finger E-Box Binding Homeobox 1 (ZEB1). In addition, role of ZEB1-AS1 has been approved in diverse malignancies such as colorectal cancer, breast cancer, glioma, hepatocellular carcinoma and gastric cancer. ZEB1-AS1 serves as a sponge for a number of microRNAs, namely miR-577, miR-335-5p, miR-101, miR-505-3p, miR-455-3p, miR-205, miR-23a, miR-365a-3p, miR-302...
Source: Pathology, Research and Practice - April 30, 2023 Category: Pathology Authors: Soudeh Ghafouri-Fard Arian Askari Kimia Behzad Moghadam Bashdar Mahmud Hussen Mohammad Taheri Mohammad Samadian Source Type: research
Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A
CONCLUSION: Altogether, our study showed that high expression of circPDS5B exacerbated IS through recruitment of hnRNP to stabilize Runx1/ZNF24 and subsequently inactivate VEGF-A. Our findings suggest circPDS5B may be a novel therapeutic target for IS.PMID:36925052 | DOI:10.1016/j.nbd.2023.106080
Source: Neurobiology of Disease - March 16, 2023 Category: Neurology Authors: Zhongzhong Jiang Yugang Jiang Source Type: research
The Involvement of Kr üppel-like Factors in Cardiovascular Diseases
Life (Basel). 2023 Feb 2;13(2):420. doi: 10.3390/life13020420.ABSTRACTKrüppel-like factors (KLFs) are a set of DNA-binding proteins belonging to a family of zinc-finger transcription factors, which have been associated with many biological processes related to the activation or repression of genes, inducing cell growth, differentiation, and death, and the development and maintenance of tissues. In response to metabolic alterations caused by disease and stress, the heart will undergo cardiac remodeling, leading to cardiovascular diseases (CVDs). KLFs are among the transcriptional factors that take control of many physiolog...
Source: Atherosclerosis - February 25, 2023 Category: Cardiology Authors: Michelle G Santoyo-Suarez Jimena D Mares-Montemayor Gerardo R Padilla-Rivas Juan Luis Delgado-Gallegos Adriana G Quiroz-Reyes Jorge A Roacho-Perez Diego F Benitez-Chao Lourdes Garza-Oca ñas Gilberto Arevalo-Martinez Elsa N Garza-Trevi ño Jose Francisco Source Type: research
Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway
CONCLUSION: These findings suggested that Sirt1 may regulate microglial activation and inflammation by targeting the Shh/Gli-1 signaling pathway following OGD/R injury. Schematic representation of Sirt1 regulating the microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury via mediation of Shh/Gli-1 signaling pathway.PMID:36725745 | DOI:10.1007/s11033-022-08167-6
Source: Molecular Biology Reports - February 1, 2023 Category: Molecular Biology Authors: Hongyan Liao Jiagui Huang Jie Liu Huimin Zhu Yue Chen Xuemei Li Jun Wen Qin Yang Source Type: research
Identifying potential therapeutic targets for ischemic stroke through immune infiltration analysis and construction of a programmed cell death ‑related ceRNA network
Exp Ther Med. 2022 Sep 21;24(5):680. doi: 10.3892/etm.2022.11616. eCollection 2022 Nov.ABSTRACTThe present study aimed to uncover the underlying mechanisms and potential intervention targets of ischemic stroke (IS). An immune cell infiltration analysis using CIBERSORT was performed on two stroke-related datasets from the Gene Expression Omnibus database to generate a competitive endogenous RNA (ceRNA) network. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were used to predict potential biological functions of the network. Differentially expressed genes in the ceRNA net...
Source: Experimental and Therapeutic Medicine - October 3, 2022 Category: General Medicine Authors: Yiteng Cui Xin Zhou Pingping Meng Shanshan Dong Ziwei Wang Tongye Liu Xiaomin Liu Yunteng Cui Yuyang Wang Qiang Wang Source Type: research
