Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway

CONCLUSION: These findings suggested that Sirt1 may regulate microglial activation and inflammation by targeting the Shh/Gli-1 signaling pathway following OGD/R injury. Schematic representation of Sirt1 regulating the microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury via mediation of Shh/Gli-1 signaling pathway.PMID:36725745 | DOI:10.1007/s11033-022-08167-6

Source: Molecular Biology Reports - February 1, 2023 Category: Molecular Biology Authors: Hongyan Liao Jiagui Huang Jie Liu Huimin Zhu Yue Chen Xuemei Li Jun Wen Qin Yang Source Type: research