Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A

CONCLUSION: Altogether, our study showed that high expression of circPDS5B exacerbated IS through recruitment of hnRNP to stabilize Runx1/ZNF24 and subsequently inactivate VEGF-A. Our findings suggest circPDS5B may be a novel therapeutic target for IS.PMID:36925052 | DOI:10.1016/j.nbd.2023.106080

Source: Neurobiology of Disease - March 16, 2023 Category: Neurology Authors: Zhongzhong Jiang Yugang Jiang Source Type: research