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A Bioinspired Nitrone Precursor to a Stabilized Nitroxide Radical
Free Radic Biol Med. 2021 Mar 30:S0891-5849(21)00190-8. doi: 10.1016/j.freeradbiomed.2021.03.030. Online ahead of print.ABSTRACTNitrones derived from natural antioxidants are emerging as highly specific therapeutics against various human diseases, including stroke, neurodegenerative pathologies, and cancer. However, the development of useful pseudo-natural nitrones requires the judicious choice of a secondary metabolite as the precursor. Betalains are nitrogen-containing natural pigments that exhibit marked antioxidant capacity and pharmacological properties and, hence, are ideal candidates for designing multifunctional ni...
Source: Free Radical Biology and Medicine - April 2, 2021 Category: Biology Authors: Amanda Capistrano Pinheiro Rodrigo Boni Fazzi Larissa Cerrato Esteves Caroline Oliveira Machado Felipe Augusto D örr Ernani Pinto Yocefu Hattori Jacinto Sa Ana Maria da Costa Ferreira Erick Leite Bastos Source Type: research

Vitamin C: historical perspectives and heart failure
AbstractVitamin C (Vit C) is an ideal antioxidant as it is easily available, water soluble, very potent, least toxic, regenerates other antioxidants particularly Vit E, and acts as a cofactor for different enzymes. It has received much attention due to its ability in limiting reactive oxygen species, oxidative stress, and nitrosative stress, as well as it helps to maintain some of the normal metabolic functions of the cell. However, over 140 clinical trials using Vit C in different pathological conditions such as myocardial infarction, gastritis, diabetes, hypertension, stroke, and cancer have yielded inconsistent results....
Source: Heart Failure Reviews - October 8, 2020 Category: Cardiology Source Type: research

Overlooked Virus Killer
Sales of vitamin C supplements have tripled in the last few weeks… And the most powerful kind of vitamin C is sold out on Amazon. (More on that in a minute.) I’m glad to see people turning to vitamin C. But the the chewable form you usually find at the drugstore won’t give you the boost you’re looking for. You see, absorption — or bioavailability — is an issue, and your body can only absorb about 500 mg of this conventional form of vitamin C before you hit saturation. And that’s nowhere near enough. In a moment I’ll show you a better form of vitamin C… and how you can take ...
Source: Al Sears, MD Natural Remedies - May 6, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Nutrition Source Type: news

Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Dietary Vitamin C in Human Health.
Abstract Vitamin C is essential to prevent scurvy in humans and is implicated in the primary prevention of common and complex diseases such as coronary heart disease, stroke, and cancer. This chapter reviews the latest knowledge about dietary vitamin C in human health with an emphasis on studies of the molecular mechanisms of vitamin C maintenance as well as gene-nutrient interactions modifying these relationships. Epidemiological evidence indicates 5% prevalence for vitamin C deficiency and 13% prevalence for suboptimal status even in industrialized countries. The daily intake (dose) and the corresponding systemi...
Source: Advances in Food and Nutrition Research - February 27, 2018 Category: Nutrition Authors: Granger M, Eck P Tags: Adv Food Nutr Res Source Type: research

Supplement warning: Overdosing on this to lower high blood pressure could be deadly
SUPPLEMENTS popularly used include vitamin C, vitamin D3 and omega-3 - and potassium may also be taken to ward off high blood pressure, heart disease, stroke, arthritis, cancer, digestive disorders, and infertility. However, too much of the mineral could be deadly.
Source: Daily Express - Health - August 1, 2017 Category: Consumer Health News Source Type: news

Nature’s Most Powerful Age Fighter?
When I lecture at anti-aging conferences around the world, I get a good sense of what the leading anti-aging physicians are thinking about. And I’m surprised by how many are still holding out hope for an anti-aging “drug.” But I’m not holding my breath. And even if the FDA approved a drug for aging, it would likely include a laundry list of side effects, and only affect a small range of age-related decline. I’ve always had more faith in nature. Many of the most powerful age fighters are naturally occurring, and they do a better job of supporting and lengthening your telomeres than any drug. Te...
Source: Al Sears, MD Natural Remedies - July 6, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Anti-Aging Nutrition omega 3 telomere vitamin C Source Type: news