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Association of plasma homocysteine level with vaso-occlusive crisis in sickle cell anemia patients of Odisha, India
AbstractVascular complications of sickle cell anemia (SCA) are influenced by many factors. Elevated plasma homocysteine (Hcy) is supposed to be an independent risk factor and is either genetic or nutritional origin. The present study evaluated the plasma Hcy level, MTHFR C677T gene polymorphism, effect of folic acid (FA) supplementation ‚ and hemato-biochemical parameters in SCA and their effect on the vaso-occlusive crisis (VOC) in SCA patients of an Asian-Indian haplotype population. One hundred twenty cases of SCA (HbSS) and 50 controls with normal hemoglobin(HbAA) were studied. It was found that the plasma Hcy level ...
Source: Annals of Hematology - September 9, 2019 Category: Hematology Source Type: research

Physiological and pathophysiological significance of vitamin B9. Summary on the occasion of the 30-year introduction of folic acid as a dietary supplement.
Abstract Vitamin B9, also known as folate, can be found in natural and synthetic forms, mostly in vegetables or folic acid containing food supplements. By participating in the proper cell development and division, its presence is indispensable for certain basic metabolic processes. The decreased folate level of the body, mainly caused by environmental and hereditary factors as well as aging, can lead to genetic, epigenetic and metabolic changes. It can be related to the development of megaloblastic anemia, various cardiovascular diseases (such as atherosclerosis, stroke) obstetrical complications (such as abruptio...
Source: Orvosi Hetilap - June 30, 2019 Category: General Medicine Authors: Zsigrai S, Kalmár A, Valcz G, Szigeti KA, Barták BK, Nagy ZB, Igaz P, Tulassay Z, Molnár B Tags: Orv Hetil Source Type: research

Fatal folic acid toxicity in humans - Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A.
Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingest...
Source: SafetyLit - March 11, 2017 Category: Global & Universal Tags: Home and Consumer Product Safety Source Type: news

Fatal Folic Acid Toxicity in Humans.
Abstract Folic acid is B-9 vitamin. Folic acid is prescribed commonly for pregnant women to prevent neural tube defects in the fetus, patients under chemotherapy, pernicious anemia and to reduce the risk of stroke and cardiovascular disease. Acute or chronic ingestion of a large dose of folic acid generally manifests as neurological complications, which are reversible. In this present case, a 23-year-old pregnant woman committed suicide by consuming folic acid tablets and succumbed to death within 36 h. Postmortem toxicological analysis detected folic acid in viscera. Death following acute consumption of folic aci...
Source: Journal of Forensic Sciences - March 5, 2017 Category: Forensic Medicine Authors: Devnath GP, Kumaran S, Rajiv R, Shaha KK, Nagaraj A Tags: J Forensic Sci Source Type: research

Editorial: Efficacy of Folic Acid in Primary Prevention of Stroke Among Patients With Hypertension in China
After folic acid had been documented to reduce birth defects, the United States mandated folic acid food fortification in grain products in 1996 and implemented the policy by 1998. 1 Around this time, controversy surfaced on adverse effects of folic acid, namely its possible role in promoting carcinogenesis. However, data over the next decade failed to provide sufficient evidence to support such a claim.1 Of note, folic acid, in some instances can mask anemia from B12 deficiency and may interact with the therapeutic levels of certain medications.
Source: Journal of the American Society of Hypertension - August 18, 2015 Category: Cardiology Authors: Sangita Goel, Franz H. Messerli Source Type: research

Near-elimination of folate-deficiency anemia by mandatory folic acid fortification in older US adults: Reasons for Geographic and Racial Differences in Stroke study 2003-2007.
CONCLUSION: Our data suggest that, after mandatory folic acid fortification, the prevalence of folate-deficiency anemia is nearly nonexistent in a community-dwelling population in the United States. PMID: 23945721 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - August 14, 2013 Category: Nutrition Authors: Odewole OA, Williamson RS, Zakai NA, Berry RJ, Judd SE, Qi YP, Adedinsewo DA, Oakley GP Tags: Am J Clin Nutr Source Type: research