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Effects of vitamin B < sub > 12 < /sub > deficiency on risk and outcome of ischemic stroke
Clin Biochem. 2023 May 27:110591. doi: 10.1016/j.clinbiochem.2023.110591. Online ahead of print.ABSTRACTIschemic stroke is the most prevalent form of stroke and has a high incidence in older adults, characterized by high morbidity, mortality, disability, and recurrence rate. Vitamin B12 deficiency is prevalent in the elderly and has been reported to be associated with ischemic stroke. The mechanisms maybe include the disorder of methylation metabolism, accumulation of toxic metabolites, immune dysfunction, affecting gut microbial composition and gut-brain immune homeostasis, and toxic stress responses to the brain. Vitamin...
Source: Clinical Biochemistry - May 29, 2023 Category: Biochemistry Authors: Li Zhou Xiaosong Song Jiani Wang Yongjun Tan Qin Yang Source Type: research

The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK)
ConclusionsHigher plasma PAr was independently associated with increased risk of incident stroke in all participants and across all subgroups stratified by conventional risk predictors. Our novel findings point to and expand the range of inflammation and immune activation processes that may be relevant for the pathogenesis and prevention of stroke. This trial was registered at clinicaltrials.gov as NCT03013725.
Source: American Journal of Clinical Nutrition - January 26, 2018 Category: Nutrition Source Type: research

The PAr index, an indicator reflecting altered vitamin B-6 homeostasis, is associated with long-term risk of stroke in the general population: the Hordaland Health Study (HUSK).
Conclusions: Higher plasma PAr was independently associated with increased risk of incident stroke in all participants and across all subgroups stratified by conventional risk predictors. Our novel findings point to and expand the range of inflammation and immune activation processes that may be relevant for the pathogenesis and prevention of stroke. This trial was registered at clinicaltrials.gov as NCT03013725. PMID: 29381795 [PubMed - in process]
Source: The American Journal of Clinical Nutrition - January 1, 2018 Category: Nutrition Authors: Zuo H, Tell GS, Ueland PM, Nygård O, Vollset SE, Midttun Ø, Meyer K, Ulvik A Tags: Am J Clin Nutr Source Type: research

Relation between vitamin B12 and SYNTAX Score.
CONCLUSION: In our study, we found significant relationship between vitamin B12 deficiency and SYNTAX score demonstrating the severity and complexity of coronary artery disease. PMID: 27391912 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - July 7, 2016 Category: Cardiology Authors: Cerit L, Duygu H, Gulsen K, Kemal H, Tosun O, Ozcem B, Cerit Z, Gunsel A Tags: Kardiol Pol Source Type: research

Mp6: homocysteine level in pfo related stroke patients with respect to medical therapy vs pfo closure
Conclusions We found that compared with routine medical therapy, PFO closure reduced tHcy level in patients with mild hyperhomocysteinemia. Since PFO stroke patients tend to be younger, the life-time risk of even mildly elevated tHcy may be important for future thrombotic risk. Understanding the mechanism of PFO-related tHcy changes is important in optimizing medical treatment (e.g, folate replacement); studies are ongoing. Abstract MP6 Figure 1
Source: Journal of Investigative Medicine - February 25, 2016 Category: Research Authors: Deng, W., Wickham, T., McMullin, D., Feeney, K., Silverman, S., Inglessis, I., Palacios, I., Lo, E., Buonanno, F., Ning, M. Tags: Moderated Poster, 11:45 PM - 1:05 PM, Wednesday, April 13, 2016 Source Type: research

Homocysteine and migraine. A narrative review.
This article is hence aimed to provide an overview of epidemiological evidence about the association between homocysteine and migraine published in cross-sectional, prospective or interventional studies. Overall, the evidence gathered from cross-sectional studies that measured plasma homocysteine levels suggests that the epidemiological link between the plasma concentration of this biomarker and migraine is very weak, at best. Contradictory evidence emerged from interventional studies, in which treatment of hyperhomocysteinemia with folic acid or vitamin B supplementation was effective to lower plasma homocysteine and decr...
Source: International Journal of Clinical Chemistry - March 5, 2014 Category: Chemistry Authors: Lippi G, Mattiuzzi C, Meschi T, Cervellin G, Borghi L Tags: Clin Chim Acta Source Type: research

Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis
Conclusions: B vitamin supplementation for homocysteine reduction significantly reduced stroke events, especially in subjects with certain characteristics who received appropriate intervention measures.
Source: Neurology - October 7, 2013 Category: Neurology Authors: Ji, Y., Tan, S., Xu, Y., Chandra, A., Shi, C., Song, B., Qin, J., Gao, Y. Tags: Stroke prevention, Nutritional, All Cerebrovascular disease/Stroke, Clinical trials Systematic review/meta analysis, Class II ARTICLE Source Type: research