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Nutrition: Tribulus Terrestris
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Total 9 results found since Jan 2013.
Investigating the in vivo effect of Tribulus terrestris extract in MCAO rats by using LC-MS-based metabolomics combined with the molecular docking
This study aimed to investigate the protective effect of TT extract, named TT15, on middle cerebral artery occlusion (MCAO) rats by metabolomics and molecular docking, and find the targets of action and the material basis of TT15 against IS. The results of the infarct volume and neurological defect scores confirmed the efficacy of TT15. The serum metabolomics analysis using LC-MS revealed that Model group animals experienced a variety of metabolic disturbances when compared to the Sham group. TT15 can restore the MCAO-induced serum metabolite changes by modulating multiple metabolic pathways. Six enzymes were highlighted b...
Source: Biomedical Chromatography : BMC - March 8, 2023 Category: Biomedical Science Authors: Xingxing Li Wenjun Guo Liang Zhao Dandan Xu Xiaohang Xu Yuqing Han Chengyan Wang Yingzi Jiang Yang Wang Yajuan Xu Source Type: research
Eucommia ulmoides Oliver-Tribulus terrestris L. Drug Pair Regulates Ferroptosis by Mediating the Neurovascular-Related Ligand-Receptor Interaction Pathway- A Potential Drug Pair for Treatment Hypertension and Prevention Ischemic Stroke
ConclusionsThe active ingredients of EUO-TT drug pair may act on proteins associated with the neuroactive ligand-receptor interaction pathway to regulate ferroptosis in vascular neurons cells, ultimately affecting the onset and progression of hypertension.
Source: Frontiers in Neurology - March 8, 2022 Category: Neurology Source Type: research
Multi-omics analysis of brain tissue metabolome and proteome reveals the protective effect of gross saponins of Tribulus terrestris L. fruit against ischemic stroke in rat
Publication date: Available online 1 June 2021Source: Journal of EthnopharmacologyAuthor(s): Yang Wang, Wenjun Guo, Shengxu Xie, Yue Liu, Dandan Xu, Geng Chen, Yajuan Xu
Source: Journal of Ethnopharmacology - June 1, 2021 Category: Drugs & Pharmacology Source Type: research
Integrating metabolomics and network pharmacology to explore the protective effect of gross saponins of Tribulus terrestris L. fruit against ischemic stroke in rat
Publication date: Available online 5 August 2020Source: Journal of EthnopharmacologyAuthor(s): Wenjun Guo, Yang Wang, Meiling Fan, Shengxu Xie, Hongyu Zhao, Jifeng Wang, Yue Liu, Dongming Xu, Yajuan Xu
Source: Journal of Ethnopharmacology - August 12, 2020 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 24, Pages 793: GC-MS-Based Metabolomics to Reveal the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat
In this study, the protective effect of GSTTF on ischemic stroke in a middle cerebral artery occlusion (MCAO) rat model was investigated by the GC-MS-based metabolomics approach. 2,3,5-triphenyltetrazolium chloride (TTC) staining of brain tissues showed that GSTTF significantly reduced the infarct area after MCAO surgery. Metabolomic profiling showed a series of metabolic perturbation occurs in ischemic stroke compared with sham group. GSTTF can reverse the MCAO-induced serum metabolic deviations by regulating multiple metabolic pathways including fatty acids metabolism, amino acids metabolism, and carbohydrates metabolism...
Source: Molecules - February 22, 2019 Category: Chemistry Authors: Yang Wang Hongyu Zhao Yue Liu Wenjun Guo Yanru Bao Manqi Zhang Tunhai Xu Shengxu Xie Xinyu Liu Yajuan Xu Tags: Article Source Type: research
Proteomic analysis reveals the renoprotective effect of Tribulus terrestris against obesity-related glomerulopathy in rats.
In conclusion, TT may play a protective role against ORG in rats.
PMID: 29984733 [PubMed - as supplied by publisher]
Source: Biological and Pharmaceutical Bulletin - July 6, 2018 Category: Drugs & Pharmacology Authors: Jiang YH, Jiang LY, Wu S, Jiang WJ, Xie L, Li W, Yang CH Tags: Biol Pharm Bull Source Type: research
Vascular protective effects of aqueous extracts of Tribulus terrestris on hypertensive endothelial injury
In conclusion, TT demonstrated anti-hypertensive and endothelial protective effects by regulating Erk2, FAK and NF-κB p65.
Source: Chinese Journal of Natural Medicines - September 21, 2017 Category: Complementary Medicine Source Type: research
Development of collateral veins as a favorable prognostic factor for complete recovery in cerebral venous thrombosis due to Tribulus terrestris
Source: International Journal of Stroke - July 23, 2015 Category: Neurology Authors: Claudio Liguori, Fabio Placidi, Francesca Leonardis, Marina Diomedi, Nicola Biagio Mercuri, Maria Grazia Marciani, Paolo Stanzione, Fabrizio Sallustio Tags: Letter to the editor Source Type: research
