Filtered By:
Nutrition: Sodium

This page shows you your search results in order of relevance. This is page number 10.

Order by Relevance | Date

Total 1017 results found since Jan 2013.

Estimating the cost consequence of the early use of botulinum toxin in post-stroke spasticity: Secondary analysis of a randomised controlled trial
CONCLUSIONS: Treating spasticity early in stroke patients at risk of contractures with botulinum toxin leads to a significant reduction in contracture costs. The cost per improvement of Barthel and Action Research Arm Test indicates that the intervention costs less and is more effective.TRIAL REGISTRATION DATA: EudraCT(2010-021257-39) and ClinicalTrials.gov-Identifier:NCT01882556.PMID:36325678 | DOI:10.1177/02692155221133522
Source: Clinical Rehabilitation - November 3, 2022 Category: Rehabilitation Authors: Cameron Lindsay Ioan Humphreys Ceri Phillips Anand Pandyan Source Type: research

How to Tell The Difference Between Heat Stress, Exhaustion, and Stroke
The terminology around heat injuries and illness is often confusing. As extreme heat warnings sweep the U.S., here is what you need to know about heat stress, heat exhaustion, and heat stroke. A 90°F-day might be perfect for the beach. But once you start working your body, whether it’s mowing the lawn, going for a hike, or sprinting to catch the bus, your metabolism ramps up, burning fuel and raising your body’s core temperature. Your heart compensates by pumping blood away from your overheated organs to your skin, where dilating blood vessels can dissipate the heat with the help of evaporating sweat. If yo...
Source: TIME: Health - July 18, 2023 Category: Consumer Health News Authors: Aryn Baker Tags: Uncategorized Climate Is Everything Explainer extreme weather healthscienceclimate Source Type: news

Do SGLT2 inhibitors and GLP-1 receptor agonists modulate differently the risk of stroke ? Discordance between randomised controlled trials and observational studies
Diabetes Metab. 2023 Sep 5:101474. doi: 10.1016/j.diabet.2023.101474. Online ahead of print.ABSTRACTStroke represents a major burden in patients with type 2 diabetes, yet this cerebrovascular complication has been less carefully investigated than the risk of cardiovascular mortality, heart failure and renal disease. Some data suggested that glucagon peptide-1 receptor agonists (GLP-1RAs) exert a better protection against stroke than sodium-glucose cotransporter 2 inhibitors (SGLT2is). However, this conclusion was derived from indirect comparisons in absence of any head-to-head randomised controlled trial (RCT). The present...
Source: Diabetes and Metabolism - September 7, 2023 Category: Endocrinology Authors: Andr é J Scheen Source Type: research

Which Patients With Ischemic Stroke and Insulin Resistance May Benefit From Pioglitazone?
The Insulin Resistance Intervention After Stroke (IRIS) trial has reported that treating insulin resistance with the peroxisome proliferator –activated receptor γ agonist pioglitazone hydrochloride reduced recurrent stroke or myocardial infarction (MI) by about one-fourth compared with placebo (pioglitazone, 9.0% vs placebo, 11.8%; hazard ratio [HR], 0.76; 95% CI, 0.62-0.93) in 3876 patients with recent (<6 months) ischemic stroke or transient ischemic attack and insulin resistance but without diabetes, heart failure, or bladder cancer. Pioglitazone was also associated with less incident diabetes vs placebo (3.8% vs ...
Source: JAMA Neurology - September 18, 2017 Category: Neurology Source Type: research

Interleukin-18 from neurons and microglia mediates depressive behaviors in mice with post-stroke depression.
In this study, we demonstrate that in IL-18 level in the ischemic brain significantly increased in mice with depression-like behaviors that caused by the combined use of chronic spatial restraint stress and middle cerebral artery occlusion. Interestingly, IL-18 expression was mainly found in neurons at early phase and in microglia in late phase. Injection of exogenous IL-18 in to the amygdala, but not the hippocampus or the striatum, caused severe depression-like behaviors. On the contrary, the blockage of endogenous IL-18 by IL-18 binding protein, a specific antagonist of IL-18, rescued depressive phenotypes in SIR mice. ...
Source: Brain, Behavior, and Immunity - April 5, 2020 Category: Neurology Authors: Wu D, Zhang G, Zhao C, Yang Y, Miao Z, Xu X Tags: Brain Behav Immun Source Type: research

Overexpression of HDAC6, but not HDAC3 and HDAC4 in the penumbra after photothrombotic stroke in the rat cerebral cortex and the neuroprotective effects of α-phenyl tropolone, HPOB, and sodium valproate.
Abstract Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat brain cortex, and tested the potential neuroprotector ability of their inhibitors. The background level of HDAC3, HDAC4 and HDAC6 in the rat cerebral cortex was relatively low. HDAC3 localized in the nuclei of some neurons and few astrocytes. HDAC4 was found in the neuronal cytoplasm. After PTS, their levels in penumbra did not change, but...
Source: Brain Research Bulletin - June 23, 2020 Category: Neurology Authors: Demyanenko SV, Dzreyan VA, Uzdensky AB Tags: Brain Res Bull Source Type: research

Meningioma preceding CASPR2 antibody limbic encephalitis with a stroke mimic: A case report
We report a contactin-associated protein-like 2-antibody (CASPR2-Ab)-positive patient who presented with atypical LE. Diagnoses: CASPR2-Ab-positive LE was the presumed diagnosis. Re-evaluation of cerebrospinal fluid (CSF) samples revealed autoantibodies targeting CASPR2 at an immunoglobulin G titer of 1:1. The clinical presentation of subacute onset seizures, abnormal electroencephalography, hypermetabolism on positron emission tomography, good immunotherapy response, and the presence of specific antibodies in serum supports a diagnosis of autoimmune LE. Intervention: The patient received glucocorticoids (1â€...
Source: Medicine - June 11, 2021 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Rapid and improved oral absorption of N-butylphthalide by sodium cholate-appended liposomes for efficient ischemic stroke therapy
Drug Deliv. 2021 Dec;28(1):2469-2479. doi: 10.1080/10717544.2021.2000678.ABSTRACTAs a multi-target drug to treat ischemic stroke, N-butylphthalide (NBP) is extremely water-insoluble and exhibits limited oral bioavailability, impeding its wide oral application. Effective treatment of ischemic stroke by NBP requires timely and efficient drug exposure, necessitating the development of new oral formulations. Herein, liposomes containing biosurfactant sodium cholate (CA-liposomes) were systemically investigated as an oral NBP delivery platform because of its high biocompatibility and great potential for clinical applications. T...
Source: Drug Delivery - November 12, 2021 Category: Drugs & Pharmacology Authors: Ailing Zhang Jianbo Li Shuaishuai Wang Yaru Xu Qinglian Li Zhe Wu Chenxu Wang Haiyang Meng Jinjie Zhang Source Type: research