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Nutrition: Ginkgo
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Total 93 results found since Jan 2013.
Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway
Am J Chin Med. 2022 Jul 29:1-33. doi: 10.1142/S0192415X22500665. Online ahead of print.ABSTRACTCurrently, therapies for ischemic stroke are limited. Ginkgolides, unique Folium Ginkgo components, have potential benefits for ischemic stroke patients, but there is little evidence that ginkgolides improve neurological function in these patients. Clinical studies have confirmed the neurological improvement efficacy of diterpene ginkgolides meglumine injection (DGMI), an extract of Ginkgo biloba containing ginkgolides A (GA), B (GB), and K (GK), in ischemic stroke patients. In the present study, we performed transcriptome analys...
Source: The American Journal of Chinese Medicine - July 28, 2022 Category: Complementary Medicine Authors: Tuan-Jie Wang Zi-Yin Wu Chun-Hua Yang Liang Cao Zhen-Zhong Wang Ze-Yu Cao Ming-Yang Yu Meng-Ru Zhao Chen-Feng Zhang Wen-Jun Liu Bin-Jiang Zhao Xue-Qi Shang Yu Feng Hui Wang Li-Li Deng Bao-Guo Xiao Hong-Yan Guo Wei Xiao Source Type: research
Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats
Conclusions EGb 761 could improv motor function especially gait impairments among pMCAO rat model related to the decreased neuronal damage. Therefore, it might be the potential to be explored further as an effective therapeutic drug to treat post stroke motor dysfunctions. Graphical abstract
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research
Ginkgo diterpene lactones inhibit cerebral ischemia/reperfusion induced inflammatory response in astrocytes via TLR4/NF-κB pathway in rats
Conclusions:In summary, GDL attenuate cerebral ischemic injury, inhibits platelet aggregation and astrocytes activation. The anti-inflammatory activity might be associated with the downregulation of TLR4/NF-κB signal pathway. Our present findings provide an innovative insight into the novel treatment of GDL in ischemic stroke therapy.Graphical abstract
Source: Journal of Ethnopharmacology - October 31, 2019 Category: Drugs & Pharmacology Source Type: research
Folium < em > Ginkgo < /em > extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) protects against focal cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome activation
CONCLUSIONS: Xingxiong injection prevents cerebral ischaemia/reperfusion injury via activating the Akt/Nrf2 pathway and inhibiting NLRP3 inflammasome. These findings provide experimental evidence for clinical use of drugs in the treatment of ischaemic stroke.PMID:35060427 | DOI:10.1080/13880209.2021.2014895
Source: Pharmaceutical Biology - January 21, 2022 Category: Drugs & Pharmacology Authors: Ting Zhu Bin-Yu Fang Xiang-Bao Meng Shu-Xia Zhang Hong Wang Ge Gao Fei Liu Yu Wu Jin Hu Gui-Bo Sun Xiao-Bo Sun Source Type: research
Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients with memory complaints.
CONCLUSION Ginkgo biloba extract did not reduce risk for Alzheimer disease in elderly patients who reported memory complaints to their primary care physicians.Ginkgo biloba extract vs placebo for incident Alzheimer disease in elderly patients with memory complaints†YearGinkgo biloba extractPlaceboRRR (95% CI)NNT10.7%1.0%28% (-61 to 68)Not significantRRI (CI)NNH21.7%1.0%65% (-19 to 236)Not significant†Abbreviations defined in Glossary. RRR, RRI, NNT, NNH, and CI calculated from placebo event rates and hazard ratios in article.
PMID: 23318341 [PubMed - in process]
Source: Annals of Internal Medicine - January 15, 2013 Category: Internal Medicine Authors: Hirsch C Tags: Ann Intern Med Source Type: research
Voodoo Medicine: Time To Stop
The world's most celebrated athlete standing on the podium in Rio in honor of receiving yet another gold medal has something important in common with your lazy uncle throwing back a cold one in his Barcalounger. Yes, swimming powerhouse Michael Phelps, purple-spotted from cupping therapy, and your slovenly relative with a beer gut both share a bond -- a weakness in succumbing to the allure of voodoo medicine. Modern-day snake oil salesmen hawking quick cures and TV doctors peddling the latest diet miracle with blatantly ridiculous claims are everywhere on the tube, social media, the supermarket and old-fashioned billboards...
Source: Science - The Huffington Post - August 12, 2016 Category: Science Source Type: news
Long-term pre-treatment of antioxidant Ginkgo biloba extract EGb-761 attenuates cerebral-ischemia-induced neuronal damage in aged mice.
Abstract
Antioxidant activity has been attributed to the neuroprotective effects of Ginkgo biloba extract EGb-761 on brain disorders including ischemic stroke. It is suggested that oxidative stress implicates in neuron injuries during aging. However, whether or not EGb-761 could be used to treat age-related cerebral ischemia is unclear. In the present study, we directly studied the protective effects of EGb-761 in brain ischemia in the mice with different age. As expected, the recovery from brain damages was impaired in aged mice (24 months) in an animal model of middle cerebral artery occlusion (MCAO). Notably, a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 14, 2016 Category: Drugs & Pharmacology Authors: Zhou X, Qi Y, Chen T Tags: Biomed Pharmacother Source Type: research
Diterpene ginkgolides protect against cerebral ischemia/reperfusion damage in rats by activating Nrf2 and CREB through PI3K/Akt signaling.
This study was designed to investigate the neuroprotective effects of DGMI components against ischemic stroke in vivo and in vitro. Acute cerebral ischemic injury was induced in rats by occlusion of the middle cerebral artery (MCA) for 1.5 h followed by 24 h reperfusion. The rats were treated with DGMI (1, 3 and 10 mg/kg, iv) at the onset of reperfusion and 12 h after reperfusion. Administration of DGMI significantly decreased rat neurological deficit scores, reduced brain infarct volume, and induced protein kinase B (Akt) phosphorylation, which prompted the nuclear translocation of nuclear factor-erythroid 2-related facto...
Source: Acta Pharmacologica Sinica - March 15, 2018 Category: Drugs & Pharmacology Authors: Zhang W, Song JK, Yan R, Li L, Xiao ZY, Zhou WX, Wang ZZ, Xiao W, Du GH Tags: Acta Pharmacol Sin Source Type: research
Neurodegeneration after transient brain ischemia in aged mice: Beneficial effects of bilobalide.
In conclusion, aged mice show some differences in their response to transient ischemia when compared with young mice. Bilobalide has prominent neuroprotective properties in mice of all ages.
PMID: 23850645 [PubMed - as supplied by publisher]
Source: Brain Research - July 11, 2013 Category: Neurology Authors: Schwarzkopf TM, Koch KA, Klein J Tags: Brain Res Source Type: research
Ginkgo Biloba (EGb 761®) Augments the Repair and Regeneration Process by Enhancing Neurogenesis after Experimental Stroke in Mice
The Journal of Alternative and Complementary Medicine May 2014, Vol. 20, No. 5: A6-A6.
Source: The Journal of Alternative and Complementary Medicine - May 7, 2014 Category: Complementary Medicine Tags: article Source Type: research
