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Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Journal of Medicine and Life - May 11, 2023 Category: General Medicine Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research

Diagnostics and treatment of post-stroke dysphagia
CONCLUSION: Timely management of dysphagia is necessary to reduce complications.PMID:37160432 | DOI:10.1007/s00115-023-01483-7
Source: Der Nervenarzt - May 9, 2023 Category: Neurology Authors: Bendix Labeit Paul Muhle Rainer Dziewas Sonja Suntrup-Krueger Source Type: research

Associations of dietary patterns with risk of incident atrial fibrillation in the REasons for Geographic And Racial Differences in Stroke (REGARDS)
ConclusionsWhile specific dietary patterns have been associated with AF risk factors, our findings fail to show an association between diet patterns and AF development.
Source: European Journal of Nutrition - April 29, 2023 Category: Nutrition Source Type: research

The effect of bempedoic acid an ATP-citrate lyase inhibitor on cardiovascular risk factors in rats with experimentally induced myocardial infarction and hyperlipidemia
Cell Mol Biol (Noisy-le-grand). 2022 Sep 30;68(10):94-99. doi: 10.14715/cmb/2022.68.10.15.ABSTRACTControl of hyperlipidemia is believed to reduce major cardiovascular events such as cardiovascular death, myocardial infarction, nonfatal stroke, hospitalization for unstable angina, and coronary revascularization. The benefits of monotherapy with Bempedoic acid (BA) as a hypolipidemic agent given after induction of myocardial infarction (MI) in reducing the risk of acute MI worth being investigated, therefore this study was designed to investigate the effectiveness of Bempedoic acid on reducing cardiovascular risk factors in ...
Source: Cellular and Molecular Biology - April 28, 2023 Category: Molecular Biology Authors: Mahmood Salim Yaseen Nidhal Mohammed Ali Source Type: research

Molecules, Vol. 28, Pages 3802: Essential and Potentially Toxic Elements (PTEs) Content in European Tea (Camellia sinensis) Leaves: Risk Assessment for Consumers
ni Truzzi Tea (Camellia sinensis) is the second most consumed beverage worldwide, playing a key role in the human diet. Tea is considered a healthy drink, as its consumption has been linked to a lower risk of cardiovascular disease-related events and death, stroke, metabolic syndrome and obesity. However, several studies have shown that C. sinensis is a hyperaccumulator of Al and other elements that are considered potentially toxic. In the present study, the contents of 15 elements (both essential and toxic) were determined for the first time in tea leaves collected in tea gardens located in six different European c...
Source: Molecules - April 28, 2023 Category: Chemistry Authors: Girolametti Annibaldi Illuminati Damiani Carloni Truzzi Tags: Article Source Type: research

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