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Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non-diabetic chronic kidney disease
CONCLUSIONS: There is currently insufficient evidence to determine the effectiveness of ACEi or ARB in patients with stage 1 to 3 CKD who do not have DM. The available evidence is overall of very low certainty and high risk of bias. We have identified an area of large uncertainty for a group of patients who account for most of those diagnosed as having CKD.PMID:37466151 | DOI:10.1002/14651858.CD007751.pub3
Source: Cochrane Database of Systematic Reviews - July 19, 2023 Category: General Medicine Authors: Tess E Cooper Claris Teng David J Tunnicliffe Brydee A Cashmore Giovanni Fm Strippoli Source Type: research

Trends in diabetes-related complications in Singapore, 2013 –2020: A registry-based study
ConclusionWe found that DM and its complications represent an important challenge for healthcare in Singapore. Improvements in the trends of DM macrovascular complications were observed. However, trends in DM microvascular complications remain a cause for concern.
Source: PLoS One - October 11, 2022 Category: Biomedical Science Authors: Joshua Kuan Tan Source Type: research

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case –control study
ConclusionThis study suggested that MTR andMTHFRpolymorphisms may contribute to increase the risk of GC.
Source: Molecular Genetics & Genomic Medicine - March 17, 2019 Category: Genetics & Stem Cells Authors: Lusha Wei, Fanglin Niu, Jiamin Wu, Fulin Chen, Hua Yang, Jing Li, Tianbo Jin, Yifei Wu Tags: ORIGINAL ARTICLE Source Type: research

Establishment and validation of a prediction model for ischemic stroke risks in patients with type 2 diabetes
Diabetes is a formidable global health threat because of its high prevalence and numerous complications. Furthermore, diabetes is a leading cause of mortality and microvascular and macrovascular diseases, including coronary diseases, cerebrovascular diseases, and peripheral vascular diseases. A recent study reports that risk of stroke in patients with type 2 diabetes is two to five times higher than the general population[1]. The World Health Organization MONICA project reported that stroke incidence is higher among ethnic Chinese population than among Western population [2].
Source: Diabetes Research and Clinical Practice - February 17, 2018 Category: Endocrinology Authors: Tsai-Chung Li, Hsiang-Chi Wang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Chih-Hsueh Lin, Sing-Yu Yang, Cheng-Chieh Lin Source Type: research

2018 consensus of the Taiwan Society of Cardiology and the Diabetes Association of Republic of China (Taiwan) on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases
Publication date: Available online 13 February 2018 Source:Journal of the Chinese Medical Association Author(s): Chern-En Chiang, Shih-Yi Lin, Tsung-Hsien Lin, Tzung-Dau Wang, Hung-I Yeh, Jung-Fu Chen, Chia-Ti Tsai, Yi-Jen Hung, Yi-Heng Li, Ping-Yen Liu, Kuan-Cheng Chang, Kang-Ling Wang, Ting-Hsing Chao, Kou-Gi Shyu, Wei-Shiung Yang, Kwo-Chang Ueng, Pao-Hsien Chu, Wei-Hsian Yin, Yen-Wen Wu, Hao-Min Cheng, Shyi-Jang Shin, Chien-Ning Huang, Lee-Ming Chuang, Shing-Jong Lin, San-Jou Yeh, Wayne Huey-Herng Sheu, Jiunn-Lee Lin The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. Patients...
Source: Journal of the Chinese Medical Association - February 14, 2018 Category: General Medicine Source Type: research

Three years of the nationwide post-acute stroke care program in Taiwan
In conclusion, the Taiwan's PAC-CVD program is an innovative and essentially effective national program of post-acute stroke care. We believe such experience should be helpful for policy makers of stroke care worldwide.
Source: Journal of the Chinese Medical Association - October 9, 2017 Category: General Medicine Source Type: research