Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case –control study

ConclusionThis study suggested that MTR andMTHFRpolymorphisms may contribute to increase the risk of GC.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Twenty-two higher education associations and rights groups released a statement on August 12, 2019 cautioning against an effort by the Federal Bureau of Investigation (FBI), the National Institutes of Health (NIH), and other government officials to monitor certain Chinese scientists working at American universities. The statement cites an NPR report that intelligence agencies are encouraging U.S. research universities to monitor students and visiting scholars from Chinese state-affiliated research institutions. The statement reads in part, “This move seemingly stems from growing suspicion that the Chinese governm...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
Sialyl Lewis A (sLeA, also known as CA19-9), a tetrasaccharide selectively and highly expressed on advanced adenocarcinomas including colon, stomach, and pancreatic cancers, has long been considered as an attractive target for active and passive vaccination. While progress in antibodies targeting tumor-associated protein antigens resulted in an impressive array of therapeutics for cancer treatment, similar progress in exploiting tumor-associated carbohydrate antigens, such as sLeA, has been hampered by the lack of a detailed understanding of the singular characteristics of these antigens. We have addressed this issue by an...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Despite recent therapeutic advances, prostate cancer remains a leading cause of cancer-related death. A subset of castration-resistant prostate cancers become androgen receptor (AR) signaling independent and develop neuroendocrine prostate cancer (NEPC) features through lineage plasticity. These NEPC tumors, associated with aggressive disease and poor prognosis, are driven, in part, by aberrant expression of N-Myc, through mechanisms that remain unclear. Integrative analysis of the N-Myc transcriptome, cistrome, and interactome using in vivo, in vitro, and ex vivo models (including patient-derived organoids) identified a l...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Induction of memory CD8+ T cells is important for controlling infections such as malaria and HIV/AIDS and for cancer immunotherapy. Accurate assessment of antigen-specific (Ag-specific) CD8+ T cells is critical for vaccine optimization and for defining correlates of protection. However, conditions for determining Ag-specific CD8+ T cell responses ex vivo using intracellular cytokine staining (ICS) may be variable, especially in humans with complex antigens. Here, we used an attenuated whole parasite malaria vaccine model in humans and various experimental infections in mice to show that the duration of antigenic stimulatio...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ03653A, PaperHuiping Wang, Libang He, Peng Zhang, Jie Zhang, Zhenhua Chen, Xiuli Ren, Xifan Mei Targeted delivery of therapeutic drug into cancer cells is a facile method to improve the therapeutic efficacy. Focused on this point, the doxorubicin (DOX) -loaded hydroxyapatite (HAP) nanorods consisting of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Lab Chip, 2019, Accepted Manuscript DOI: 10.1039/C9LC00598F, PaperZhen Yuan, Lei Hou, Mallika Bariya, Hnin Yin Yin Nyein, Li-Chia Tai, Wenbo Ji, Lu Li, Ali Javey Sweat sensors introduced in recent years have targeted a variety of sweat features and biomarkers for non-invasive health monitoring. Amongst these targets, reliable monitoring of sweat rate is crucial due... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Lab Chip latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC05826E, CommunicationJia Li, Le Li Zeng, Kai Xiong, Thomas Wheildon Rees, Chengzhi Jin, Weijun Wu, Yu Chen, Liangnian Ji, Hui Chao Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative species (ROS). Herein, we design a biotin-modified Ru(II) complex as photosensitizer (denoted as Ru-Biotin). Ru-Biotin can selectively... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC03379C, CommunicationAnnemiek Uvyn, Ruben De Coen, Olivier De Wever, Kim Deswarte, Bart Lambrecht, Bruno De Geest Triggering antibody-mediated innate immune mechanisms to kill cancer cells is an attractive therapeutic avenue. In this context, recruitment of endogenous antibodies to the cancer cell surface could be a viable... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
CONCLUSION: This study suggested that MTR and MTHFR polymorphisms may contribute to increase the risk of GC. PMID: 30884202 [PubMed - as supplied by publisher]
Source: Molecular Medicine - Category: Molecular Biology Authors: Tags: Mol Genet Genomic Med Source Type: research
Publication date: Available online 26 October 2015 Source:The Lancet Author(s): Maigeng Zhou, Haidong Wang, Jun Zhu, Wanqing Chen, Linhong Wang, Shiwei Liu, Yichong Li, Lijun Wang, Yunning Liu, Peng Yin, Jiangmei Liu, Shicheng Yu, Feng Tan, Ryan M Barber, Matthew M Coates, Daniel Dicker, Maya Fraser, Diego González-Medina, Hannah Hamavid, Yuantao Hao, Guoqing Hu, Guohong Jiang, Haidong Kan, Alan D Lopez, Michael R Phillips, Jun She, Theo Vos, Xia Wan, Gelin Xu, Lijing L Yan, Chuanhua Yu, Yong Zhao, Yingfeng Zheng, Xiaonong Zou, Mohsen Naghavi, Yu Wang, Christopher J L Murray, G...
Source: The Lancet - Category: Journals (General) Source Type: research
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