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Factors contributing to poor COVID-19 outcomes in diabetic patients: Findings from a single-center cohort study
This article is a retrospective cohort study that include diabetic patients hospitalized with COVID-19 infection. A definition of diabetes was based on th e past history of diabetes or if the HbA1c was 6.5% or higher. Demographics, clinical characteristics, comorbidities, laboratory results, and complications were extracted from the electronic medical records. The mortality rate increased with increasing age (from 5.56% in younger patients to 46% in t he elderly) and with severity (from 25.71% in moderate cases to 43.77% in critical cases). We found that a critical severity on admission (OR: 5.26, 95% CI: 1.28–21.66,p = ...
Source: PLoS One - August 31, 2023 Category: Biomedical Science Authors: Nosayba Al-Azzam Source Type: research

Plasma exosome proteomics reveals the pathogenesis mechanism of post-stroke cognitive impairment
Aging (Albany NY). 2023 May 20;15. doi: 10.18632/aging.204738. Online ahead of print.ABSTRACTExploration and utilization of exosome biomarkers and their related functions provide the possibility for the diagnosis and treatment of post-stroke cognitive impairment (PSCI). To identify the new diagnostic and prognostic biomarkers of plasma exosome were uzed label-free quantitative proteomics and biological information analysis in PSCI patients. Behavioral assessments were performed, including the Mini-Mental Status Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Barthel index, the Morse Fall Seale (MFS) betwe...
Source: Aging - May 21, 2023 Category: Biomedical Science Authors: Baoyun Qi Lingbo Kong Xinxing Lai Linshuang Wang Fei Liu Weiwei Ji Dongfeng Wei Source Type: research

The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We show that a small rise in cytoplasmic Ca2+ concentration ([Ca2+]i) in pericytes activated chloride efflux through the Ca2+-gated anion channel TMEM16A, thus depolarizing the cell and opening voltage-gated calcium channels. This mechanism strongly amplified the pericyte [Ca2+]i rise and capillary constriction evoked by contractile agonists and ischemia. In a rodent stroke model, TMEM16A inhibition slowed the ischemia-evoked pericyte [Ca2+]i rise, ...
Source: Journal of Clinical Investigation - May 2, 2022 Category: Biomedical Science Authors: Nils Korte, Zeki Ilkan, Claire L. Pearson, Thomas Pfeiffer, Prabhav Singhal, Jason R. Rock, Huma Sethi, Dipender Gill, David Attwell, Paolo Tammaro Source Type: research

Fat-to-muscle Ratio: A New Indicator for Coronary Artery Disease in Healthy Adults
Conclusion: In this study, a high FMR was significantly associated with CAC. A large-scale prospective study on the association with FMR and cardiovascular diseases is necessary to confirm this relationship.PMID:34790047 | PMC:PMC8579285 | DOI:10.7150/ijms.62871
Source: International Journal of Medical Sciences - November 18, 2021 Category: Biomedical Science Authors: Youngmi Eun Su Nam Lee Sang-Wook Song Ha-Na Kim Se-Hong Kim Yun-Ah Lee Sung-Goo Kang Jun-Seung Rho Ki-Dong Yoo Source Type: research

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