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Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice
Conclusion Although secreted platelet 5-HT does not appear to play a crucial role in the development of reperfusion injury after stroke, it is essential to amplify the second phase of platelet activation through SOCE and plays an important role in thrombus stabilization.
Source: PLoS One - January 22, 2016 Category: Biomedical Science Authors: Karen Wolf et al. Source Type: research

Is There a Link between Exertional Heat Stroke and Susceptibility to Malignant Hyperthermia?
Conclusions The unexpected high prevalence of the MHS trait after EHS suggested a latent disturbance of calcium homeostasis that accounted for the positive IVCT results. This study did not determine whether EHS patients have an increased risk of MH, and it could not determine whether MH susceptibility is a risk factor for EHS.
Source: PLoS One - August 10, 2015 Category: Biomedical Science Authors: Emmanuel Sagui et al. Source Type: research

Biomarkers of cardiovascular disease risk in women
Cardiovascular disease (CVD), including coronary heart disease and stroke, is the leading cause of death among U.S. women and men. Established cardiovascular risk factors such as smoking, diabetes, hypertension, and elevated total cholesterol, and risk prediction models based on such factors, perform well but do not perfectly predict future risk of CVD. Thus, there has been much recent interest among cardiovascular researchers in identifying novel biomarkers to aid in risk prediction. Such markers include alternative lipids, B-type natriuretic peptides, high-sensitivity troponin, coronary artery calcium, and genetic markers.
Source: Metabolism - Clinical and Experimental - October 29, 2014 Category: Biomedical Science Authors: JoAnn E. Manson, Shari S. Bassuk Source Type: research

Plaque hemorrhage in carotid artery disease: Pathogenesis, clinical and biomechanical considerations
Abstract: Stroke remains the most prevalent disabling illness today, with internal carotid artery luminal stenosis due to atheroma formation responsible for the majority of ischemic cerebrovascular events. Severity of luminal stenosis continues to dictate both patient risk stratification and the likelihood of surgical intervention. But there is growing evidence to suggest that plaque morphology may help improve pre-existing risk stratification criteria. Plaque components such a fibrous tissue, lipid rich necrotic core and calcium have been well investigated but plaque hemorrhage (PH) has been somewhat overlooked. In this r...
Source: Journal of Biomechanics - February 3, 2014 Category: Biomedical Science Authors: Zhongzhao Teng, Umar Sadat, Adam J. Brown, Jonathan H. Gillard Source Type: research

Rate of Change of Carotid Intima‐Media Thickness with Magnesium Administration in Abcc6−/− Mice
Abstract Pseudoxanthoma elasticum (PXE), caused by mutations in the ABCC6 gene, demonstrates progressive build‐up of calcium phosphate and proteoglycans in the skin, eye, and arteries, and is associated to myocardial infarctions, stroke, blindness, and elevated carotid intima‐media thickness (CIMT). Although CIMT reduction with magnesium (Mg) has been documented in a mouse model for PXE (Abcc6−/−), it is not clear if Mg is effective in humans with PXE to reduce CIMT. To examine this, we calculated the rate of change of CIMT (washout) in 15‐ and 12‐month‐old Abcc6−/− mice fed standard rodent diet with or w...
Source: Clinical and Translational Science - April 19, 2013 Category: Biomedical Science Authors: Erine A. Kupetsky, Fred Rincon, Jouni Uitto Tags: Brief Report Source Type: research

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