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Diabetes and Heart Failure: Multi-Omics Approaches
This article reviewed the recent omics-driven discoveries in the diagnosis and treatment of type 2 diabetes and heart failure with focus on the common molecular mechanisms.
Source: Frontiers in Physiology - August 6, 2021 Category: Physiology Source Type: research

The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature
Publication date: Available online 7 November 2019Source: Food Research InternationalAuthor(s): Samad Ghaffari, Neda RoshanravanAbstractHypertension (HTN) is a worldwide epidemic in both developed and developing countries. It is one of the leading causes of major health problems such as cardiovascular disease, stroke, and heart attack. In recent years, several studies have reported associations between specific dietary ingredients and improving HTN. Nutraceuticals are natural food components with pharmacological properties. Reports suggest that functional foods and nutraceutical ingredients might support patients to obtain...
Source: Food Research International - November 8, 2019 Category: Food Science Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Coronary artery calcium score to guide hypertension therapy!
Hypertension is the most prevalent non-communicable disease, estimated to affect 1.13 billion individuals nowadays. It is the leading preventable cause of mortality worldwide and a major risk factor for coronary artery disease, heart failure, stroke and chronic renal diseases in developed and developing countries.1,2. Worldwide, the aging population, decreased fitness and obesity epidemic have contributed to the increased prevalence of hypertension3. Given that, it poses a significant health and economic challenge to both developed and developing countries.
Source: Atherosclerosis - January 25, 2019 Category: Cardiology Authors: Ahmed Aljizeeri, Ahmed Alsaileek, Mouaz H. Al-Mallah Tags: Editorial Source Type: research

EuroPCR 2018 Roundup: Medtronic touts BP reductions, no major adverse events in renal denervation trial
Medtronic (NYSE:MDT) today released six-month results from a trial of its Symplicity Spyral renal denervation system exploring its use treating hypertensive patients who are already taking anti-hypertension medications, touting significant reductions in blood pressure and no major adverse safety events. Results were presented at the 2018 EuroPCR annual meeting in Paris and were published in The Lancet. In the trial, patients were prescribed up to three anti-hypertensive medications, including diuretics, calcium channel blockers, ACE/ARB inhibitors or beta blockers, the Fridley, Minn.-based company said. Patients were then...
Source: Mass Device - May 23, 2018 Category: Medical Devices Authors: Fink Densford Tags: Blood Management Cardiac Implants Cardiovascular Clinical Trials Abbott Medtronic ReCor Medical Source Type: news

Title: Beyond Malnutrition: The Role of Sanitation in Stunted Growth
Charles W. Schmidt, MS, an award-winning science writer from Portland, ME, has written for Discover Magazine, Science, and Nature Medicine. Background image: WHO About This Article open Citation: Schmidt CW. 2014. Beyond malnutrition: the role of sanitation in stunted growth. Environ Health Perspect 122:A298–A303; http://dx.doi.org/10.1289/ehp.122-A298 News Topics: Children’s Health, Diet and Nutrition, Gastrointestinal Health, International Environmental Health, Microbial Agents, Musculoskeletal Health, Drinking Water Quality, Sanitation Published: 1 November 2014 PDF Version (2.8 MB) Worldwide, stuntin...
Source: EHP Research - October 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Children's Health Diet and Nutrition Drinking Water Quality Gastrointestinal Health International Environmental Health Microbial Agents Musculoskeletal Health November 2014 Sanitation Source Type: research

“De-Risking” Risk Reduction Should Coronary Artery Calcium Scoring Be the Gatekeeper to Preventive Pharmacotherapy With the Polypill? ∗
The cardiovascular disease (CVD) epidemic remains the leading cause of death worldwide (1). Widespread adoption of the Western diet and lifestyle by populations in emergent countries with low or middle income has resulted in dramatic increases in the incidence of coronary heart disease and stroke. An overwhelming proportion of the cardiovascular risk is explained by the cumulative presence of classic and potentially modifiable risk factors, and this effect does not seem to be influenced by sex, ethnicity, or geography (2). Therefore, to effectively reduce risk and improve outcomes, prevention strategies should be conducted...
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - February 3, 2014 Category: Radiology Source Type: research

“De-Risking” Risk Reduction: Should Coronary Artery Calcium Scoring Be the Gatekeeper to Preventive Pharmacotherapy With the Polypill?∗
The cardiovascular disease (CVD) epidemic remains the leading cause of death worldwide . Widespread adoption of the Western diet and lifestyle by populations in emergent countries with low or middle income has resulted in dramatic increases in the incidence of coronary heart disease and stroke. An overwhelming proportion of the cardiovascular risk is explained by the cumulative presence of classic and potentially modifiable risk factors, and this effect does not seem to be influenced by sex, ethnicity, or geography . Therefore, to effectively reduce risk and improve outcomes, prevention strategies should be conducted and i...
Source: Journal of the American College of Cardiology - October 25, 2013 Category: Cardiology Authors: William Wijns, Dan Rusinaru Tags: Cardiometabolic Risk: Editorial Comment Source Type: research

Saturated fat link with heart disease questioned
This article is one doctor's opinion based on his own knowledge, research and experience. However, it is fair to say there is an ongoing debate about how far cholesterol is a risk factor for heart disease, especially in people who are otherwise healthy. There is also a similar debate about the use of statins in people who have no evidence of cardiovascular disease. This is alongside ongoing research into the components of LDL and the different types of lipoproteins known to increase risk the most. None of this relevant new evidence is covered by the news reporting.   What should you eat? There is no need to change curren...
Source: NHS News Feed - October 23, 2013 Category: Consumer Health News Tags: Heart/lungs Food/diet QA articles Source Type: news

Any defence of sugar is pure confection | Aseem Malhotra
More and more people are challenging the food industry's PR machine. The evidence shows that sugar, not fat, is the enemyThe public health minister, Anna Soubry, has commented that the poor are more likely to be obese. It is well known that social status is linked to health, but her comments were also motivated by a mentality that victimises the most vulnerable. She should really be directing her criticism at the food industry. There is no doubt that an oversupply of cheap junk food fuelled by unregulated and irresponsible marketing limits our ability to make healthy choices. But there is an equally important question that...
Source: Guardian Unlimited Science - January 24, 2013 Category: Science Authors: Aseem Malhotra Tags: Comment Food & drink industry Obesity Health guardian.co.uk Health policy Society UK news Life and style Business Science Comment is free Source Type: news