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Condition: Ischemic Stroke
Nutrition: Calcium

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Total 639 results found since Jan 2013.

IN BRAIN POST-ISCHEMIC PLASTICITY, Na < sup > + < /sup > /Ca < sup > 2+ < /sup > EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE
Cell Calcium. 2022 May 29;105:102608. doi: 10.1016/j.ceca.2022.102608. Online ahead of print.ABSTRACTThe intricate glia interaction occurring after stroke strongly depend on the maintenance of intraglial ionic homeostasis. Among the several ionic channels and transporters, the plasmamembrane Na+/Ca2+ exchanger (NCX) represents a key player in maintaining astroglial Na+ and Ca2+ homeostasis. Here, using a combined in vitro, in vivo and ex vivo experimental strategy we evaluated whether microglia responding to ischemic injury may influence the morphological and the transcriptional plasticity of post-ischemic astrocytes. Astr...
Source: Cell Calcium - June 6, 2022 Category: Cytology Authors: Antonella Casamassa Ornella Cuomo Anna Pannaccione Pasquale Cepparulo Giusy Laudati Valeria Valsecchi Lucio Annunziato Giuseppe Pignataro Source Type: research

Dietary genistein and 17 β-estradiol implants differentially influence locomotor and cognitive functions following transient focal ischemia in middle-aged ovariectomized rats at different lengths of estrogen deprivation
This study suggests that the neuroprotective effects of dietary genistein on motor and cognitive functions are distinctly influenced by the length of estrogen deprivation following focal ischemia. SIGNIFICANCE: There is an increasing postmenopausal population opting for homeopathic medicines for the management of menopausal symptoms due to the perceived distrust in estrogen use as hormone replacement. Basic and clinical studies support the notion that early, but not delayed, hormone replacement after menopause is beneficial. Furthermore, evidence suggests that delaying hormone replacement augments the detrimental, rather t...
Source: Hormones and Behavior - June 2, 2022 Category: Endocrinology Authors: Anthony Oppong-Gyebi Daniel Metzger Philip H Vann Nathalie Sumien Derek A Schreihofer Source Type: research

Comparison of Serum Selenium Levels Between Patients with Newly Diagnosed Atrial Fibrillation and Normal Controls
Biol Trace Elem Res. 2022 May 9. doi: 10.1007/s12011-022-03281-9. Online ahead of print.ABSTRACTAtrial fibrillation (AF) is the most common sustained dysrhythmia in the elderly population. It is estimated to affect more than 30 million people worldwide. AF occurs when abnormal electrical impulses start to activate in the atria and override the heart's natural pacemaker, which can no longer control the heart's rhythm. Since atrial contractility is impaired in AF, blood flow in the atria becomes stasis over time and causes thrombus formation. This thrombus causes the risk of embolism and causes complications such as stroke. ...
Source: Biological Trace Element Research - May 8, 2022 Category: Biology Authors: Isa Ardahanli Halil Ibrahim Ozkan Source Type: research

Endovascular Therapy for Intracranial Giant Cell Arteritis
ConclusionEndovascular treatment, including PTA with or without stenting or calcium channel blocker infusion, may be effective therapies in medically refractory GCA with intracranial stenosis.
Source: Clinical Neuroradiology - May 3, 2022 Category: Neurology Source Type: research

The Ca2+-gated channel TMEM16A amplifies capillary pericyte contraction and reduces cerebral blood flow after ischemia
Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We show that a small rise in cytoplasmic Ca2+ concentration ([Ca2+]i) in pericytes activated chloride efflux through the Ca2+-gated anion channel TMEM16A, thus depolarizing the cell and opening voltage-gated calcium channels. This mechanism strongly amplified the pericyte [Ca2+]i rise and capillary constriction evoked by contractile agonists and ischemia. In a rodent stroke model, TMEM16A inhibition slowed the ischemia-evoked pericyte [Ca2+]i rise, ...
Source: Journal of Clinical Investigation - May 2, 2022 Category: Biomedical Science Authors: Nils Korte, Zeki Ilkan, Claire L. Pearson, Thomas Pfeiffer, Prabhav Singhal, Jason R. Rock, Huma Sethi, Dipender Gill, David Attwell, Paolo Tammaro Source Type: research

Serum Calcium Levels and in-Hospital Infection Risk in Patients with Acute Ischemic Stroke
Source: Neuropsychiatric Disease and Treatment - May 2, 2022 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Association of DNA Methylation Patterns in 7 Novel Genes With Ischemic Stroke in the Northern Chinese Population
Conclusion: Our results demonstrate that DNA methylation plays a crucial part in ischemic stroke. The methylation of these 7 genes may be potential diagnostic biomarker for ischemic stroke.PMID:35480311 | PMC:PMC9035884 | DOI:10.3389/fgene.2022.844141
Source: Atherosclerosis - April 28, 2022 Category: Cardiology Authors: Hongwei Sun Jia Xu Bifeng Hu Yue Liu Yun Zhai Yanyan Sun Hongwei Sun Fang Li Jiamin Wang Anqi Feng Ying Tang Jingbo Zhao Source Type: research

Macrocalcification of intracranial vertebral artery may be related to in-stent restenosis: lessons learned from optical coherence tomography
Conclusions This study suggests a potential relationship between macrocalcifications and the risk of in-stent restenosis of the intracranial vertebral artery. These preliminary findings obtained from a limited sample should be verified by prospective large-scale studies.
Source: Journal of NeuroInterventional Surgery - April 19, 2022 Category: Neurosurgery Authors: Xu, R., Yang, B., Li, L., Wang, T., Lu, X., Luo, J., Zhang, X., Dong, J., Wang, Y., Hua, Y., Ma, Y., Jiao, L. Tags: Ischemic stroke Source Type: research

Integrating serum proteomics and metabolomics to compare the common and distinct features between acute aggressive ischemic stroke (APIS) and acute non-aggressive ischemic stroke (ANPIS)
In this study, we integrated serum proteomics and metabolomics to explore the similarities and differences in pathophysiological processes between APIS and ANPIS. The global metabolic networks have been constructed, and the crucial common pathophysiological processes and the key distinct pathophysiological features between APIS and ANPIS were investigated based on the differentially expressed proteins and metabolites (DEPs/DEMs). Furthermore, pivotal serum proteins (SAA1 and S100A9) were detected in a dependent set to validate the key pathophysiological characteristics, as well as to assess the possibility of them being us...
Source: Journal of Proteomics - April 14, 2022 Category: Biochemistry Authors: Minchao Lai Xiaojun Zhang Danya Zhou Xiaojuan Zhang Mengting Zhu Qingxian Liu Ye Zhang Dian Wang Source Type: research