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Condition: Ischemic Stroke
Nutrition: Calcium
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Total 639 results found since Jan 2013.
Triiodothyronine Aggravates Global Cerebral Ischemia-Reperfusion Injury in Mice
In this study, we examined the effect of T3 administration on DNA fragmentation induced by neuronal death and the activation of inflammatory cells such as astrocytes and microglia in the hippocampus following GCI. The content of nucleosomes generated by DNA fragmentation in the hippocampus was increased by GCI and further increased by T3 administration. The protein expression levels of glial fibrillary acidic protein (GFAP), an astrocytic marker, and Ionized calcium binding adaptor protein 1 (Iba1), a microglial marker, in the hippocampus were also increased by GCI and further increased by T3 administration. The levels of ...
Source: Biological and Pharmaceutical Bulletin - December 2, 2021 Category: Drugs & Pharmacology Authors: Masaru Doshi Shiro Watanabe Yujin Natori Makoto Hosoyamada Yutaka Hirashima-Akae Source Type: research
Role of Na < sup > + < /sup > /K < sup > + < /sup > -ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
J Mol Med (Berl). 2021 Nov 27. doi: 10.1007/s00109-021-02143-6. Online ahead of print.ABSTRACTNa+/K+-ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is indispensable for the maintenance of electrochemical gradients across the plasma membrane and herein neuronal excitability. The widely recognized pump function of NKA closely depends on its unique structure features and conformational changes upon binding of specific ions. Various Na+-dependent secondary transport systems are rigorously controlled by the ionic gradients generated by NKA and are ...
Source: Molecular Medicine - November 28, 2021 Category: Molecular Biology Authors: Mengyuan Zhu Haijian Sun Lei Cao Zhiyuan Wu Bin Leng Jinsong Bian Source Type: research
Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
AbstractNa+/K+-ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is indispensable for the maintenance of electrochemical gradients across the plasma membrane and herein neuronal excitability. The widely recognized pump function of NKA closely depends on its unique structure features and conformational changes upon binding of specific ions. Various Na+-dependent secondary transport systems are rigorously controlled by the ionic gradients generated by NKA and are essential for multiple physiological processes. In addition, roles of NKA as a signal ...
Source: Journal of Molecular Medicine - November 27, 2021 Category: Molecular Biology Source Type: research
β2SP/TET2 complex regulates gene 5hmC modification after cerebral ischemia
J Cell Mol Med. 2021 Nov 19. doi: 10.1111/jcmm.17060. Online ahead of print.ABSTRACTβII spectrin (β2SP) is encoded by Sptbn1 and is involved in the regulation of various cell functions. β2SP contributes to the formation of the myelin sheath, which may be related to the mechanism of neuropathy caused by demyelination. As one of the main features of cerebral ischemia, demyelination plays a key role in the mechanism of cerebral ischemia injury. Here, we showed that β2SP levels were increased, and this molecule interacted with TET2 after ischemic injury. Furthermore, we found that the level of TET2 was decreased in the nuc...
Source: J Cell Mol Med - November 20, 2021 Category: Molecular Biology Authors: Xiaohua Ma Meng Zhang Rui Yan Hainan Wu Bo Yang Zhigang Miao Source Type: research
The role of rehabilitation and vitamin D supplementation on motor and psychological outcomes in poststroke patients
Post-Stroke depression affects between 12% and 72% of patients who have suffered a stroke. The association between low serum levels of 25-hydroxyvitamin D (25(OH) D) and increased risk of depression is reported in both stroke and non-stroke patients. Similarly, high 25(OH) D levels might be associated with greater functional improvement during rehabilitation program.
We wanted to investigate the effects of an intensive rehabilitation on poststroke outcomes. We wondered if the daily rehabilitation of motor and cognitive functions could also have an effect on mood and functional abilities in addition to or as an alternati...
Source: Medicine - November 12, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
