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Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson's disease
Biomed Pharmacother. 2023 Jan 20;159:114268. doi: 10.1016/j.biopha.2023.114268. Online ahead of print.ABSTRACTParkinson's disease (PD) is marked by the gradual degeneration of dopaminergic neurons and the intracellular build-up of Lewy bodies rich in α-synuclein protein. This impairs various aspects of the mitochondria including the generation of ROS, biogenesis, dynamics, mitophagy etc. Mitochondrial dynamics are regulated through the inter and intracellular movement which impairs mitochondrial trafficking within and between cells. This inter and intracellular mitochondrial movement plays a significant role in maintainin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 22, 2023 Category: Drugs & Pharmacology Authors: Rachit Jain Nusrat Begum Kamatham Pushpa Tryphena Shashi Bala Singh Saurabh Srivastava Sachchida Nand Rai Emanuel Vamanu Dharmendra Kumar Khatri Source Type: research

Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling
Biomed Res Int. 2022 Dec 24;2022:3959845. doi: 10.1155/2022/3959845. eCollection 2022.ABSTRACTVascular remodeling refers to changes in the size, contraction, distribution, and flow rate of blood vessels and even changes in vascular function. Vascular remodeling can cause cardiovascular and cerebrovascular diseases. It can also lead to other systemic diseases, such as pulmonary hypertension, pulmonary atherosclerosis, chronic obstructive pulmonary disease, stroke, and ascites of broilers. Hypoxia is one of the main causes of vascular remodeling. Prolonged hypoxia or intermittent hypoxia can lead to loss of lung ventilation,...
Source: Biomed Res - January 3, 2023 Category: Research Authors: Xiaojuan Huang Elif Ece Akg ün Khalid Mehmood Hui Zhang Zhaoxin Tang Ying Li Source Type: research

Molecules, Vol. 27, Pages 7620: Quercetin & rsquo;s Effects on Glutamate Cytotoxicity
Molecules, Vol. 27, Pages 7620: Quercetin’s Effects on Glutamate Cytotoxicity Molecules doi: 10.3390/molecules27217620 Authors: Kade Riche Natalie R. Lenard The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate excitotoxicity occurs when a neuron is overstimulated by the neurotransmitter glutamate and causes dysregulation of intracellular calcium concentrations. Quercetin has been shown ...
Source: Molecules - November 7, 2022 Category: Chemistry Authors: Kade Riche Natalie R. Lenard Tags: Review Source Type: research

Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites
AbstractIschemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity, calcium overload, neuroinflammation, oxidative stress, mitochondrial damage, and apoptosis are known to be involved in the pathogenesis of IS, but the underlying pathophysiology mechanisms of IS are not fully clarified. During the past decade, gut microbiota were recognized as a key regulator to affect the health of the host either directly or via their metabolites. Recent studies indicate that gut bacterial dysbiosis is closely related to hypertension, diabetes, obesity, d...
Source: Translational Stroke Research - October 24, 2022 Category: Neurology Source Type: research

Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
In this study, we observed that treatment with mitochondria isolated from rat primary astrocytes enhanced cell viability and ameliorated hydrogen peroxide-damaged neurons. Interestingly, isolated astrocytic mitochondria increased the number of cells under damaged neuronal conditions, but not under normal conditions, although the mitochondrial transfer efficiency did not differ between the two conditions. This effect was also observed after transplanting astrocytic mitochondria in a rat middle cerebral artery occlusion model. These findings suggest that mitochondria transfer therapy can be used to treat acute ischemic strok...
Source: BMB Reports - October 4, 2022 Category: Biochemistry Authors: Eun-Hye Lee Minkyung Kim Seung Hwan Kim Chun-Hyung Kim Minhyung Lee Chang-Hwan Park Source Type: research

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