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Condition: Mitochondrial Disease
Nutrition: Calcium
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Total 81 results found since Jan 2013.
Primary astrocytic mitochondrial transplantation ameliorates ischemic stroke
In this study, we observed that treatment with mitochondria isolated from rat primary astrocytes enhanced cell viability and ameliorated hydrogen peroxide-damaged neurons. Interestingly, isolated astrocytic mitochondria increased the number of cells under damaged neuronal conditions, but not under normal conditions, although the mitochondrial transfer efficiency did not differ between the two conditions. This effect was also observed after transplanting astrocytic mitochondria in a rat middle cerebral artery occlusion model. These findings suggest that mitochondria transfer therapy can be used to treat acute ischemic strok...
Source: BMB Reports - October 4, 2022 Category: Biochemistry Authors: Eun-Hye Lee Minkyung Kim Seung Hwan Kim Chun-Hyung Kim Minhyung Lee Chang-Hwan Park Source Type: research
Molecular explanation of Wnt/ βcatenin antagonist pyrvinium mediated calcium equilibrium changes in aging cardiovascular disorders
Mol Biol Rep. 2022 Sep 15. doi: 10.1007/s11033-022-07863-7. Online ahead of print.ABSTRACTThe symptoms of ageing are somewhat different and can lead to the altered role of the cardiovascular system at the levels of genetic, biochemical, tissue, organ, and systems. Ageing is an autonomous cardiovascular risk factor. In the ageing rat heart, oxidative and inflammatory stress, immune cell infiltration, increasing myeloperoxidase function, elevated caspase-3 activity, and protein fibronectins were detected and associated with ageing and cardiovascular disease. The intracellular Ca2 + homeostasis disturbed in an older heart dra...
Source: Molecular Biology Reports - September 15, 2022 Category: Molecular Biology Authors: Khalid Saad Alharbi Yogendra Singh Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Imran Kazmi Fahad A Al-Abbasi Sami I Alzarea Dinesh Kumar Chellappan Sachin Kumar Singh Kamal Dua Gaurav Gupta Source Type: research
Crocins for Ischemic Stroke: A Review of Current Evidence
Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and wel...
Source: Frontiers in Pharmacology - August 5, 2022 Category: Drugs & Pharmacology Source Type: research
Age-related vascular changes exemplified by the carotid artery
Gefasschirurgie. 2022 Jun 24;27(4):1-7. doi: 10.1007/s00772-022-00901-5. Online ahead of print.ABSTRACTOne of the main risk factors for the presence of carotid stenosis and carotid-related stroke is age. The aim of this review article is to present the current state of knowledge on age-related vascular changes using carotid stenosis as an example.Vascular aging (vascular senescence) is a decrease of structural and functional properties of the vessel wall that takes place on different levels. At the multicellular level an increase in vessel volume and diameter as well as intima media thickness occurs with age mainly due to ...
Source: Atherosclerosis - July 5, 2022 Category: Cardiology Authors: Benedikt Reutersberg Philip D üppers Anna-Leonie Menges Claudia Schrimpf Alexander Zimmermann Jaroslav Pelisek Source Type: research
Therapeutic Potential of Astrocyte Transplantation
Cell Transplant. 2022 Jan-Dec;31:9636897221105499. doi: 10.1177/09636897221105499.ABSTRACTCell transplantation is an attractive treatment strategy for a variety of brain disorders, as it promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of astrocytes has come into light recently as a therapy for amyotrophic lateral sclerosis (ALS); moreover, grafting of astrocytes also showed positive results in models of other conditions ranging from neurodegenerative diseases of older age to traumatic injury and stroke. Despite clear differences in etiology, disorders such as ALS, Parkinson's, ...
Source: Cell Transplantation - June 30, 2022 Category: Cytology Authors: Nataly Hastings Wei-Li Kuan Andrew Osborne Mark R N Kotter Source Type: research
