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Total 24 results found since Jan 2013.

Predictors of Good Outcome After Endovascular Therapy for Vertebrobasilar Occlusion Stroke Clinical Sciences
Background and Purpose—Endovascular therapy is increasingly used in acute ischemic stroke treatment and is now considered the gold standard approach for selected patient populations. Prior studies have demonstrated that eventual patient outcomes depend on both patient-specific factors and procedural considerations. However, these factors remain unclear for acute basilar artery occlusion stroke. We sought to determine prognostic factors of good outcome in acute posterior circulation large vessel occlusion strokes treated with endovascular therapy.Methods—We reviewed our prospectively collected endovascular databases at ...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Mehdi Bouslama, Diogo C. Haussen, Amin Aghaebrahim, Jonathan A. Grossberg, Gregory Walker, Srikant Rangaraju, Anat Horev, Michael R. Frankel, Raul G. Nogueira, Tudor G. Jovin, Ashutosh P. Jadhav Tags: Quality and Outcomes, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research

Association of Blood Pressure With Short- and Long-Term Functional Outcome After Stroke Thrombectomy Clinical Sciences
This study aims to assess the association of BP changes during general anesthesia versus conscious sedation with functional outcome after mechanical thrombectomy.Methods—SIESTA (Sedation vs Intubation for Endovascular Stroke Treatment) was a monocentric randomized trial of general anesthesia versus conscious sedation during mechanical thrombectomy involving BP target protocols. In this post hoc analysis, BP measurements were divided into 4 phases: preintervention, prerecanalization, postrecanalization, and postintervention. We examined the association between BP and functional outcomes (defined by improvement of 24-hour ...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Schonenberger, Lorenz Uhlmann, Matthias Ungerer, Johannes Pfaff, Simon Nagel, Christina Klose, Martin Bendszus, Wolfgang Wick, Peter A. Ringleb, Meinhard Kieser, Markus A. Mohlenbruch, Julian Bosel Tags: Ischemic Stroke Original Contributions Source Type: research

Clinical diagnostic tools for screening of perioperative stroke in general surgery: a systematic review
Perioperative stroke is a devastating complication that carries high mortality and functional disability. Unfortunately, residual anaesthesia and analgesia may obscure important warning signs and may lead to a delay in the assessment and treatment of major stroke after surgery. The purpose of this review is to examine the utility of existing stroke scales, for the recognition of perioperative stroke in the general surgical population. A total of 21 stroke scales have been described in the literature. Diagnostic performance was reported in 17 scales. The majority of the stroke scales were designed to evaluate current neurol...
Source: British Journal of Anaesthesia - February 10, 2016 Category: Anesthesiology Authors: Sun, Z., Yue, Y., Leung, C. C. H., Chan, M. T. V., Gelb, A. W., on behalf of the Study Group for Perioperative Stroke In China (POSIC), on behalf of the Study Group for Perioperative Stroke In China (POSIC), Wu, Yue, Sun, Guo, Ding, Wang, Tian, Mei, Yao, Tags: Review Articles Source Type: research

Impact of Mechanical Thrombectomy on the Organization of the Management of Acute Ischemic Stroke
Background: Several trials and meta-analyses have recently demonstrated the superiority of endovascular therapy over standard medical treatment in patients presenting with acute ischemic stroke. In order to offer the best possible treatment to a maximum number of patients, many stroke care networks probably have to be reorganized. After analyzing the reliability of data in the literature, an algorithm is suggested for a pre-hospital and in-hospital alert system to improve the timeliness of subsequent treatment: a drip-and-ship approach. Summary: Five recent well-designed randomized studies have demonstrated the benefit of ...
Source: European Neurology - January 16, 2016 Category: Neurology Source Type: research

Vessel perforation during withdrawal of Trevo ProVue stent retriever during mechanical thrombectomy for acute ischemic stroke.
Abstract The authors report a case of an intracranial extravasation during the withdrawal of a Trevo ProVue stent retriever device in a patient being treated for acute ischemic stroke. An 82-year-old woman developed sudden left hemiparesis and aphasia during an urgent cardiac catheterization procedure for a non-ST elevation myocardial infarction. She had a baseline National Institutes of Health Stroke Scale (NIHSS) score of at least 10 and no improvement with intravenous administration of tissue plasminogen activator (tPA). Cerebral angiography was performed with conscious sedation, confirming an occlusion of the ...
Source: Journal of Neurosurgery - June 13, 2014 Category: Neurosurgery Authors: Leishangthem L, Satti SR Tags: J Neurosurg Source Type: research

P-008 on intent to treat adapt technique for 201 cases of anterior circulation acute ischemic stroke
We report our single center experience results of endovascular treatment of anterior circulation of ischemic stroke by the technique of direct aspiration.MethodsBetween September 2013 to March 2015 we reviewed the data of 201 patients presenting with large vessels anterior circulation occlusion for which the ADAPT technique was utilized in first intention and was associated with stentriever technique when necessary. Procedural and clinical data were collected for analysis. An univariate analysis of the following factors: Age, prior antiplatelet or anticoagulative therapy, localisation of the occlusion, an intravenous throm...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Blanc, R., Redjem, H., Bartolini, B., Ciccio, G., Smajda, S., Taylor, G., Lamrabet, S., Paraschakis, P., Piotin, M. Tags: SNIS 12th Annual Meeting Oral Poster Abstracts Source Type: research

Chapter 66 Endovascular treatment of acute ischemic stroke
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 136 Author(s): Thabele Leslie-Mazwi, James Rabinov, Joshua A. Hirsch Endovascular thrombectomy is an effective treatment for major acute ischemic stroke syndromes caused by major anterior circulation artery occlusions (commonly referred to as large vessel occlusion) and is superior to intravenous thrombolysis and medical management. Treatment should occur as quickly as is reasonably possible. All patients with moderate to severe symptoms (National Institutes of Health stroke scale >8) and a treatable occlusion should be considered. The use of ...
Source: Handbook of Clinical Neurology - July 16, 2016 Category: Neurology Source Type: research

Endovascular Treatment of Acute Ischemic Stroke Under General Anesthesia: Predictors of Good Outcome
Background: The choice of anesthetic technique, general anesthesia (GA) versus Monitored Anesthesia Care, may impact the outcome of patients undergoing endovascular treatment of acute ischemic stroke (AIS). The aim of this study was to identify the factors associated with good discharge outcome in patients receiving GA for AIS. Materials and Methods: Electronic medical records of patients above 18 years old who underwent endovascular treatment of AIS under GA at a Comprehensive Stroke Center from 2010 to 2014 were reviewed. Good outcome was defined as discharge modified Rankin Score 0 to 2 and poor outcome as modified...
Source: Journal of Neurosurgical Anesthesiology - June 12, 2018 Category: Anesthesiology Tags: Clinical Investigations Source Type: research

Postoperative Screening With the Modified National Institutes of Health Stroke Scale After Noncardiac Surgery: A Pilot Study
Background: Perioperative stroke is associated with high rates of morbidity and mortality, yet there is no validated screening tool. The modified National Institutes of Health Stroke Scale (mNIHSS) is validated for use in nonsurgical strokes but is not well-studied in surgical patients. We evaluated perioperative changes in the mNIHSS score in noncardiac, non-neurological surgery patients, feasibility in the perioperative setting, and the relationship between baseline cognitive screening and change in mNIHSS score. Methods: Patients aged 65 years and above presenting for noncardiac, non-neurological surgery were...
Source: Journal of Neurosurgical Anesthesiology - June 17, 2022 Category: Anesthesiology Tags: Short Reports Source Type: research

Carotid Artery Free-Floating Thrombus Caused by Paradoxical Embolization From Greater Saphenous Vein Ascending Thrombophlebitis
We report a case of a young woman without cardiovascular risk factors who was admitted to our emergency department with listlessness and altered mental status. The clinical examination revealed right lower limb swelling. Magnetic resonance imaging and contrast-enhanced computed tomographic scans revealed a free floating thrombus of the left internal carotid artery (ICA) with a large bilateral frontal ischemic lesion. The diagnosis of a medium-sized PFO with moderate right-to-left contrast shunting was made after transesophageal echocardiography. No other cardiac sources for embolization were detected, while an ascending th...
Source: Annals of Vascular Surgery - April 28, 2013 Category: Surgery Authors: Luigi Irace, Roberto Gabrielli, Maria Sofia Rosati, Maria Fabrizia Giannoni, Anna Castiglione, Antonella Laurito, Bruno Gossetti Tags: Case Report Abstracts Source Type: research

UCLA researchers provide first evidence of how obstructive sleep apnea damages the brain
Courtesy of Rajesh Kumar Brains with obstructive sleep apnea (left) and without UCLA researchers have reported the first evidence that obstructive sleep apnea contributes to a breakdown of the blood–brain barrier, which plays an important role in protecting brain tissue. The discovery, reported in the Sept. 1 issue of the Journal of Neuroimaging, could lead to new approaches for treating obstructive sleep apnea, which affects an estimated 22 million American adults. The disorder causes frequent interruptions in breathing during sleep because the airways narrow or become blocked. The blood–brain barrier limits harmful...
Source: UCLA Newsroom: Health Sciences - September 1, 2015 Category: Universities & Medical Training Source Type: news

NIH scientists identify spasm in women with endometriosis-associated chronic pelvic pain
(NIH/National Institute of Neurological Disorders and Stroke) Pelvic pain associated with endometriosis often becomes chronic and can persist (or recur) following surgical and hormonal interventions. According to results published in Regional Anesthesia& Pain Medicine, treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life. The study was conducted by scientists at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Source: EurekAlert! - Biology - July 11, 2019 Category: Biology Source Type: news

Revised Use of the Modified National Institutes of Health Stroke Scale for Perioperative Stroke Screening
No abstract available
Source: Journal of Neurosurgical Anesthesiology - June 17, 2022 Category: Anesthesiology Tags: Editorials Source Type: research

Following nature ' s rules, researchers develop new methods for treating degenerative neurological disease
Following nature's rules, researchers develop new methods for treating degenerative neurological disease The University of Arizona has licensed the new class of drugs designed to penetrate the blood-brain barrier to startup Teleport Pharmaceuticals. Paul Tumarkin Tuesday Tech Launch Arizonateleport-web-crop.jpg Robin Polt (right) coaches undergraduate student Hannah Kuo Feinberg as she works on a glycopeptide project in Polt ’s lab. Paul Tumarkin/Tech Launch ArizonaHealthScience and TechnologyCollege of Medicine - TucsonCollege of ScienceDeterminationExpertsExplorationTech Launch Arizona Media contact(s)Paul...
Source: The University of Arizona: Health - July 26, 2022 Category: Universities & Medical Training Authors: mittank Source Type: research

Predictors of symptomatic intracranial hemorrhage after endovascular treatment for acute large vessel occlusion: data from ANGEL-ACT registry
AbstractSymptomatic intracranial hemorrhage (SICH) is a catastrophic complication of endovascular treatment (EVT) for large vessel occlusion (LVO). We aimed to investigate the incidence and predictors of SICH after EVT. Patients were selected from the ANGEL-ACT registry. We diagnosed SICH according to the Heidelberg Bleeding Classification. Logistic regression analyses were performed to determine the independent predictors of SICH. Of the 1283 patients, SICH was observed in 116 patients (9.0%). On multivariable analysis, admission National Institutes of Health Stroke Scale (NIHSS)  >  12 (odds ratio [OR] = 1.86,...
Source: Journal of Thrombosis and Thrombolysis - August 1, 2022 Category: Hematology Source Type: research