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Total 210 results found since Jan 2013.

Janssen Announces U.S. FDA Approval of INVEGA HAFYERA ™(6-month paliperidone palmitate), First and Only Twice-Yearly Treatment for Adults with Schizophrenia
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA approval of INVEGA ...
Source: Johnson and Johnson - September 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

New Peptides as Potential Players in the Crosstalk Between the Brain and Obesity, Metabolic and Cardiovascular Diseases
According to the World Health Organization report published in 2016, 650 million people worldwide suffer from obesity, almost three times more than in 1975. Obesity is defined as excessive fat accumulation which may impair health with non-communicable diseases such as diabetes, cardiovascular diseases (hypertension, coronary artery disease, stroke), and some cancers. Despite medical advances, cardiovascular complications are still the leading causes of death arising from obesity. Excessive fat accumulation is caused by the imbalance between energy intake and expenditure. The pathogenesis of this process is complex and not ...
Source: Frontiers in Physiology - August 23, 2021 Category: Physiology Source Type: research

The importance of extended working hours for work-related injuries
Discussion of Reduction Strategies and Behavioral Responses from a North American Perspective. Euro J Trans Infra Res. 2002;2(4). 21. POPM.gov [internet] Policy, Data, Oversight. Available from: https://www.opm.gov/policy-data-oversight/pay-leave/work-sched ules/fact-sheets/alternative-work-schedules-compressed-work-schedules/. Accessed June 30, 2021. 22. Kivimäki M, Nyberg ST, Batty GD, Fransson EI, Heikkilä K, Alfredsson L, et al. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data. Lancet. 2012;380(9852):1491-7. https://doi.org/10.1016/S0140-6736(12)60...
Source: Scandinavian Journal of Work, Environment and Health - August 11, 2021 Category: Occupational Health Tags: Editorial Source Type: research

Hypertension is associated with increased mortality in patients with tuberculosis in Guinea-Bissau
Tuberculosis (TB) continues to be a major health problem in low- and middle-income countries (LMICs). In 2019, WHO estimated that there were 10 million new cases of TB, and 1.4 million deaths due to TB worldwide (World Health Organization, 2020). At the same time, LMICs face a rapid increase in the burden of noncommunicable diseases such as diabetes mellitus (DM) and cardiovascular diseases (CVD), including coronary heart disease and stroke. More than 75% of cardiovascular deaths occur in LMICs (World Health Organization, 2014).
Source: International Journal of Infectious Diseases - July 2, 2021 Category: Infectious Diseases Authors: Anneline B Seegert, Cecilie B Patsche, Armando Sifna, Victor F Gomes, Christian Wejse, Merete Storgaard, Frauke Rudolf Source Type: research

Vaccination in Older Adults: An Underutilized Opportunity to Promote Healthy Aging in India
AbstractOver the last 50 years, the Indian population aged 50 years and above (older adults) has quadrupled and is expected to comprise 404 million people in 2036, representing 27% of the country ’s projected population. Consequently, the contribution of chronic disease to older adults’ total burden of diseases in India is likely to escalate. Disease burden is notably amplified by immunosenescence, a deterioration of the immune system that develops with age, leading to increasing suscept ibility to infectious diseases and other comorbidities. Older adults with infectious diseases have a higher incidence and likelihood ...
Source: Drugs and Aging - June 14, 2021 Category: Geriatrics Source Type: research

Roche launches new ways to use their cardiovascular tests empowering clinicians to improve diagnosis and treatment of millions of people
Basel, 28 April 2021 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced a series of five new intended uses for two key cardiac biomarkers using the Elecsys ® technology: high sensitive cardiac troponin T (cTnT-hs) and N-terminal pro-brain natriuretic peptide test (NT-proBNP). These gold standard biomarkers³ have proven to be successful in supporting cardiovascular disease management and can help clinicians diagnose heart attacks⁴ (cTnT-hs) and bett er manage heart failure⁵ (NT-proBNP). Roche ' s introduction of five new intended uses for these existing, globally accepted diagnostic solutions means more people could benef...
Source: Roche Media News - April 28, 2021 Category: Pharmaceuticals Source Type: news

Sexual hormones and diabetes: The impact of estradiol in pancreatic β cell
Int Rev Cell Mol Biol. 2021;359:81-138. doi: 10.1016/bs.ircmb.2021.02.004. Epub 2021 Mar 16.ABSTRACTDiabetes is one of the most prevalent metabolic diseases and its incidence is increasing throughout the world. Data from World Health Organization (WHO) point-out that diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation and estimated 1.6 million deaths were directly caused by it in 2016. Population studies show that the incidence of this disease increases in women after menopause, when the production of estrogen is decreasing in them. Knowing the impact that estrogenic sign...
Source: International Review of Cell and Molecular Biology - April 9, 2021 Category: Cytology Authors: Beatriz Merino Marta Garc ía-Arévalo Source Type: research

Sexual hormones and diabetes: The impact of estradiol in pancreatic beta cell
Int Rev Cell Mol Biol. 2021;359:81-138. doi: 10.1016/bs.ircmb.2021.02.004. Epub 2021 Mar 16.ABSTRACTDiabetes is one of the most prevalent metabolic diseases and its incidence is increasing throughout the world. Data from World Health Organization (WHO) point-out that diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation and estimated 1.6 million deaths were directly caused by it in 2016. Population studies show that the incidence of this disease increases in women after menopause, when the production of estrogen is decreasing in them. Knowing the impact that estrogenic sign...
Source: Mol Biol Cell - April 9, 2021 Category: Molecular Biology Authors: Beatriz Merino Marta Garc ía-Arévalo Source Type: research