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Infectious Disease: Herpes
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Total 194 results found since Jan 2013.

GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren's syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.
Abstract Glutamate is the major excitatory neurotransmitter of the Central Nervous System (CNS), and it is crucially needed for numerous key neuronal functions. Yet, excess glutamate causes massive neuronal death and brain damage by excitotoxicity-detrimental over activation of glutamate receptors. Glutamate-mediated excitotoxicity is the main pathological process taking place in many types of acute and chronic CNS diseases and injuries. In recent years, it became clear that not only excess glutamate can cause massive brain damage, but that several types of anti-glutamate receptor antibodies, that are present in ...
Source: Herpes - August 1, 2014 Category: Infectious Diseases Authors: Levite M Tags: J Neural Transm Source Type: research

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after HZ infection.
Source: Neurology - July 7, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gautier, A., Brown, M. M. Tags: CORRECTED AND REPUBLISHED ARTICLES Source Type: research

A study on the association between infectious burden and Alzheimer's disease
ConclusionsIB consisting of CMV, HSV‐1, B. burgdorferi, C. pneumoniae and H. pylori is associated with AD. This study supports the role of infection/inflammation in the etiopathogenesis of AD.
Source: European Journal of Neurology - June 9, 2014 Category: Neurology Authors: X.‐L. Bu, X.‐Q. Yao, S.‐S. Jiao, F. Zeng, Y.‐H. Liu, Y. Xiang, C.‐R. Liang, Q.‐H. Wang, X. Wang, H.‐Y. Cao, X. Yi, B. Deng, C.‐H. Liu, J. Xu, L.‐L. Zhang, C.‐Y. Gao, Z.‐Q. Xu, M. Zhang, L. Wang, X.‐L. Tan, X. Xu, H.‐D. Zhou, Y. Tags: Original Article Source Type: research

The New Old Age: When Shingles Is Just the Beginning
A new study links shingles to a higher risk of stroke.
Source: NYT Health - May 16, 2014 Category: Consumer Health News Authors: By PAULA SPAN Tags: Elder Care Shingles (Disease) Herpes Viruses Medical Issues Vaccination and Immunization Source Type: news

Meningeal Disease Masquerading as Transient Ischemic Attack
Conclusions: Our study confirmed that serious meningeal disease could present as TIA, but this disease was relatively uncommon among patients treated in a TIA clinic. The findings highlight the diagnostic value of MRI in patients with suspected TIA.
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2014 Category: Neurology Authors: Line Cuinat, Nathalie Nasr, Jeanine Manuela Kamsu, Frédéric Tanchoux, Fabrice Bonneville, Vincent Larrue Tags: Case Reports Source Type: research

What Causes Ataxia?
Discussion Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy wal...
Source: PediatricEducation.org - March 31, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after the occurrence of HZ.
Source: Neurology - January 20, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gauthier, A., Brown, M. M. Tags: Stroke in young adults, Viral infections, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Analysis of a series of cases with an initial diagnosis of acute disseminated encephalomyelitis over the period 2000-2010.
CONCLUSIONS. ADEM may present at any age, including in infants. There are a number of conditions that can mimic ADEM in the early stages. PMID: 24052440 [PubMed - in process]
Source: Revista de Neurologia - September 21, 2013 Category: Neurology Authors: Rodriguez-Fernandez C, Lopez-Marin L, Lopez-Pino MA, Gutierrez-Solana LG, Soto-Insuga V, Conejo-Moreno D Tags: Rev Neurol Source Type: research

Potential Misdiagnoses of Bell's Palsy in the Emergency Department
Conclusion: Emergency providers have a very low rate of misdiagnosing Bell's palsy. The association between imaging use and misdiagnosis is likely confounded by patient acuity. Increasing age and diabetes are modest risk factors for misdiagnosis.
Source: Annals of Emergency Medicine - July 29, 2013 Category: Emergency Medicine Authors: Jahan Fahimi, Babak B. Navi, Hooman Kamel Tags: Neurology Source Type: research

Infectious burden and cognitive function: The Northern Manhattan Study
Conclusion: A measure of IB associated with stroke risk and atherosclerosis was independently associated with cognitive performance in this multiethnic cohort. Past infections may contribute to cognitive impairment.
Source: Neurology - March 25, 2013 Category: Neurology Authors: Katan, M., Moon, Y. P., Paik, M. C., Sacco, R. L., Wright, C. B., Elkind, M. S. V. Tags: All Infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia ARTICLE Source Type: research

Herpes simplex virus infection and erectile dysfunction: a nationwide population-based study.
In conclusion, HSV infections were associated with risk of ED in this cohort. PMID: 23413136 [PubMed - in process]
Source: Herpes - February 20, 2013 Category: Infectious Diseases Authors: Huang CC, Chan WL, Chen YC, Chen TJ, Chung CM, Huang PH, Lin SJ, Chen JW, Leu HB Tags: Andrology Source Type: research

Herpes simplex virus infection and erectile dysfunction: a nationwide population‐based study
In conclusion, HSV infections were associated with risk of ED in this cohort.
Source: International Journal of Andrology - December 14, 2012 Category: Sexual Medicine Authors: C.‐C. Huang, W.‐L. Chan, Y.‐C. Chen, T.‐J. Chen, C.‐M. Chung, P.‐H. Huang, S.‐J. Lin, J.‐W. Chen, H.‐B. Leu Tags: Original Article Source Type: research