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Pediatric stroke related to Lyme neuroborreliosis: Data from the Swiss NeuroPaediatric Stroke Registry and literature review.
CONCLUSIONS: Lyme Neuroborreliosis accounts for a small proportion of paediatric stroke even in an endemic country. The strong predilection towards posterior cerebral circulation with clinical occurrence of brainstem signs associated with meningeal symptoms and CSF lymphocytosis are suggestive features that should rapidly point to the diagnosis. This can confirmed by appropriate serological testing in the serum and CSF. Clinicians must be aware of this rare neurological complication of Lyme disease that demands specific antibiotic treatment. PMID: 29208342 [PubMed - as supplied by publisher]
Source: European Journal of Paediatric Neurology - November 24, 2017 Category: Neurology Authors: Monteventi O, Steinlin M, Regényi M, Roulet-Perez E, Weber P, Fluss J Tags: Eur J Paediatr Neurol Source Type: research

Prothrombotic factors do not increase the risk of recurrent ischemic events after cryptogenic stroke at young age: the FUTURE study
ConclusionsThe prevalence of prothrombotic factors and preceding infections did not significantly differ between stroke patients with a cryptogenic versus an identified cause of stroke and neither is significantly associated with an increased risk of recurrent ischemic events after cryptogenic stroke.
Source: Journal of Thrombosis and Thrombolysis - February 26, 2018 Category: Hematology Source Type: research

Cerebral vasculitis and stroke due to Lyme neuroborreliosis: A favorable clinical outcome after early antibiotic treatment
Lyme neuroborreliosis (LNB) is a disease of the nervous system caused by the spirochete Borrelia burgdorferi sensu lato genospecies, which is transmitted by the bite of infected ticks. Approximately 15% of patients with Lyme borreliosis develop neurological manifestations; most frequently meningitis, cranial neuritis or polyradiculitis [1]. Ischemic stroke due to cerebral vasculitis is rarely (
Source: Journal of the Neurological Sciences - January 24, 2017 Category: Neurology Authors: Meinie Seelen, Ido R. van den Wijngaard, Rob S. Rundervoort Tags: Letter to the Editor Source Type: research

En kvinne i 50- årene med residiverende svimmelhet.
En kvinne i 50-årene med residiverende svimmelhet. Tidsskr Nor Laegeforen. 2020 Aug 18;140(11): Authors: Eriksen E, Smebye KL, Mejlænder-Evjensvold M, Sandset EC Abstract BACKGROUND: Vasculitis caused by neuroborreliosis is one of many rare described causes of stroke. CASE PRESENTATION: A female smoker in her fifties presented with dizziness due to a left cerebellar infarction, and after general stroke workup atherosclerosis was considered the probable cause. In the preceding months she had experienced nonspecific intermittent headache, neck pain and dizziness initially attributed to prior head...
Source: Tidsskrift for den Norske Laegeforening - August 17, 2020 Category: General Medicine Authors: Eriksen E, Smebye KL, Mejlænder-Evjensvold M, Sandset EC Tags: Tidsskr Nor Laegeforen Source Type: research

Trends and Characteristics of Tuberculous Meningitis in the United States, 1993-2013 (S30.007)
Conclusions:Over the past two decades, the incidence and mortality of TBM in the US have steadily declined, but neurological complications are increasing.Study Supported by:This work was supported by the National Institute of Neurological Disorders [grant numbers K23NS082367, R01NS097443-01 to H.K.] and the Michael Goldberg Stroke Research Fund to [H.K.].Disclosure: Dr. Merkler has nothing to disclose. Dr. Chatterjee has nothing to disclose. Dr. Gialdini has nothing to disclose. Dr. Reynolds has nothing to disclose. Dr. Morris has nothing to disclose. Dr. Murthy has nothing to disclose. Dr. Thakur has received personal com...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Chatterjee, A., Gialdini, G., Reynolds, A., Morris, N., Murthy, S., Thakur, K., Kamel, H. Tags: Infectious Disease: HIV, Syphilis, Borrelia, TB, Cysticercosis, and Other Infections Source Type: research

A study on the association between infectious burden and Alzheimer's disease
ConclusionsIB consisting of CMV, HSV‐1, B. burgdorferi, C. pneumoniae and H. pylori is associated with AD. This study supports the role of infection/inflammation in the etiopathogenesis of AD.
Source: European Journal of Neurology - June 9, 2014 Category: Neurology Authors: X.‐L. Bu, X.‐Q. Yao, S.‐S. Jiao, F. Zeng, Y.‐H. Liu, Y. Xiang, C.‐R. Liang, Q.‐H. Wang, X. Wang, H.‐Y. Cao, X. Yi, B. Deng, C.‐H. Liu, J. Xu, L.‐L. Zhang, C.‐Y. Gao, Z.‐Q. Xu, M. Zhang, L. Wang, X.‐L. Tan, X. Xu, H.‐D. Zhou, Y.� Tags: Original Article Source Type: research

Amyotrophic Lateral Sclerosis (ALS) with Laboratory Abnormalities of Unknown Significance (LAUS) --Where Does It Begin and Where Does It End? (P4.144)
CONCLUSIONS: Further detailed analysis of progression rate by site of onset, sex, age, treatment will require assimilation of clinic-based datasets of properly analyzed ALS-LAUS patients from multiple clinic sites. The appropriate role of IVIg in ALS-LAUS patients requires further study following explication of the natural history of these patients compared with non-ALS-LAUS patients. The determination as to whether auto-antibodies to additional antigens may play a role in the progression rate of ALS-LAUS compared with sporadic ALS needs to be systematically studied. Study Supported by: Carolinas ALS Research FundDisclosur...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Brooks, B., Bravver, E., Langford, V., Alwan, M., Smith, N., Lucas, N., Nichols, M., Belcher, S., Lary, C., Nemeth, J., Russo, P., Wright, K., Ward, A., Holsten, S., Fischer, M., Bockenek, W., Desai, U., Lindblom, S. C., Pacicco, T., Sanjak, M. Tags: Neuroepidemiology: ALS Source Type: research

Ixodes scapularis Tissue Factor Pathway Inhibitor
Ixodes scapularis is a blood-sucking tick and the principal vector of Lyme disease, a spirochetal illness caused by Borrelia burgdorferi and now the most common vector-borne infection in the United States; more than 50,000 cases have been reported during the last ten years. The salivary gland of I. scapularis has a number of pharmacologically active molecules that help the tick to successfully feed on blood, such as inhibitors of complement system, in addition to coagulation and platelet aggregation inhibitors. This invention describes Ixolaris, a protein that inhibits the initiation of blood coagulation by inhibition of c...
Source: NIH OTT Licensing Opportunities - December 1, 2000 Category: Research Authors: admin Source Type: research

A Comparison of Three Different Bioinformatics Analyses of the 16S –23S rRNA Encoding Region for Bacterial Identification
Conclusion The higher resolution at the species level identification provided by 16S–23S rRNA encoding region NGS makes its use in routine diagnostic microbiology potentially attractive. Particularly, data analysis is one of the most important steps of a diagnostic workflow, which requires an optimal pipeline for the interpretation of the sequencing data in a short time. This study demonstrates that de novo assembly and subsequent BLASTN analysis using an in-house developed database compared to OTU clustering and mapping approaches is the most accurate and fastest approach for identification of bacterial pathogens....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

Case report: Dueling etiologies: Longitudinally extensive spinal cord lesion mimicking spinal cord infarct with simultaneous positive Lyme serology and amphiphysin antibody
ConclusionWe describe an unusual steroid-responsive, longitudinally extensive spinal cord lesion with radiological features of spinal cord infarct and a simultaneous finding of intrathecal Lyme antibodies and serum amphiphysin antibodies.
Source: Frontiers in Neurology - September 13, 2022 Category: Neurology Source Type: research