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The Limited Public Health Impact of ‘Lifestyle’ Change
Two main factors are responsible for premature disease and mortality. One is smoking, often referred to as a “lifestyle choice,” but better described as a “habit.” The other is poor nutrition resulting largely from the sugar, alcohol, salt, and saturated fat content (SASS components) of ready-to-consume food and drink, much of which is manufactured on an industrial scale. Collectively, these dietar y components are the main drivers of the global epidemic of stroke, heart attack, obesity, and type 2 diabetes.
Source: The American Journal of Medicine - July 14, 2016 Category: Journals (General) Authors: Nicholas J. Wald Tags: Editorial Source Type: research

Diabetes drug pioglitazone could get personal: Neither panacea, nor peril
When I was in training, one of my beloved mentors declared, “I never use a drug until it’s been on the market for 20 years.” I was young enough then that I couldn’t fathom being a doctor for 20 years, let alone waiting two decades to use a new drug. As my career has progressed, I’ve seen many new drugs released to the market. Some of them are truly miraculous, bringing people longer, healthier, and more productive lives. Many of them have not withstood the test of time. More than a few have even been taken off the market. Even though the Food and Drug Administration diligently reviews each new medicine before it�...
Source: New Harvard Health Information - May 5, 2016 Category: Consumer Health News Authors: Lori Wiviott Tishler, MD, MPH Tags: Diabetes Drugs and Supplements pioglitazone thiazolidinediones Source Type: news

Only the overworked die young
Follow me at @JohnRossMD Billy Joel was on to something. As the singer-songwriter suggested in “Movin’ Out,” working too hard really can give you a “heart attack-ack-ack…” And, as a recent study has also shown, stroke may be an even bigger problem than heart attack in people who are overworked. For the study, researchers from University College London compiled data on the relationship between working hours and heart attack risk in over 600,000 workers, as well as similar data on stroke risk in over 500,000 workers. They adjusted their data to compensate for individual workers’ differences due to healt...
Source: New Harvard Health Information - December 14, 2015 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Behavioral Health Heart Health Hypertension and Stroke Prevention Stress overworked Source Type: news

Red blood cell replacement, or nanobiotherapeutics with enhanced red blood cell functions?
Authors: Chang TM Abstract Why is this important? Under normal circumstances, donor blood is the best replacement for blood. However, there are exceptions: During natural epidemics (e.g., HIV, Ebola, etc.) or man-made epidemics (terrorism, war, etc.), there is a risk of donor blood being contaminated, and donors being disqualified because they have contracted disease. Unlike red blood cells (RBCs), blood substitutes can be sterilized to remove infective agents. Heart attack and stroke are usually caused by obstruction of arterial blood vessels. Unlike RBCs, which are particulate, blood substitutes are in the form o...
Source: Artificial Cells, Nanomedicine and Biotechnology - December 12, 2015 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Endocannabinoids and cardiovascular prevention: real progress?
Authors: Nodari S, Manerba A, Metra M, Dei Cas L Abstract The prevalence of obesity continues to increase and represents one of the principal causes of cardiovascular morbidity and mortality. After the discovery of a specific receptor of the psychoactive principle of marijuana, the cannabinoid receptors and their endogenous ligands, several studies have demonstrated the role of this system in the control of food intake and energy balance and its overactivity in obesity. Recent studies with the CB1 receptor antagonist rimonabant have demonstrated favorable effects such as a reduction in body weight and waist circumf...
Source: Heart International - November 28, 2015 Category: Cardiology Tags: Heart Int Source Type: research

Autocrine Effect of Vascular Endothelial Growth Factor-A is Essential for Mitochondrial Function in Brown Adipocytes
The obesity epidemic in the United States, and the accompanying condition of type 2 diabetes, puts a majority of the population at an increased risk of developing cardiovascular diseases including coronary artery disease, stroke, and myocardial infarction. In contrast to white adipose tissue (WAT), brown adipose tissue (BAT), is well vascularized, rich in mitochondria, and highly oxidative. While it is known that the angiogenic factor VEGF-A is required for brown adipocyte development, the functional consequences and exact mechanism remain to be elucidated.
Source: Metabolism - Clinical and Experimental - September 23, 2015 Category: Biomedical Science Authors: Kiana Mahdaviani, David Chess, Yuanyuan Wu, Orian Shirihai, Tamar Aprahamian Source Type: research

Get the flu vaccine, reduce your risk of death
Last year was a lousy year for the flu vaccine. Hospitalizations for flu hit a nine-year high, and the vaccine prevented flu in only 23% of all recipients, compared with 50% to 60% of recipients in prior years. Why does the flu vaccine work well in some winters and not others? The flu vaccine primes the immune system to attack two proteins on the surface of the influenza A virus, hemagglutinin (H) and neuraminidase (N). Different flu strains have different combinations of these proteins — for example, the strains targeted by recent flu vaccines are H3N2 and H1N1. Unfortunately, the influenza virus is microbiology’s ans...
Source: New Harvard Health Information - September 15, 2015 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Cold and Flu Vaccines Flu Shot flu vaccine Source Type: news

Loneliness And Isolation Are As Bad For You As Obesity, New Study Says
These days, thanks to cell phones and computers, it's easier than you'd think to spend a day without speaking to a soul other than Siri or the pizza delivery guy. But interacting with others is something we should all be more conscious of. Indeed a new study finds that isolation and loneliness threaten longevity as much as obesity. Researchers from Brigham Young University in Utah looked at nearly 35 years of studies on how loneliness, social isolation and living alone can affect your lifespan and what they found was startling. “We need to start taking our social relationships more seriously," the study's lead author Ju...
Source: Science - The Huffington Post - March 12, 2015 Category: Science Source Type: news

Cholesterol: I Told You So!
Big Brother has finally come around to what I’ve been telling my patients for almost 30 years – stop worrying about cholesterol in your diet! The influential Dietary Guidelines Advisory Committee, the nation’s top nutrition panel, has now admitted they were WRONG about cholesterol. And they have now proclaimed this former dietary evil as no longer a “nutrient of concern.”1 They were slow – and, of course, wrong for decades – but at least they got there in the end. That means eggs are back on the menu for millions of Americans – yolk and all – although my patients have been enjoying their e...
Source: Al Sears, MD Natural Remedies - March 2, 2015 Category: Complementary Medicine Authors: Dr. Al Sears Tags: Heart Health Nutrition cholesterol diet heart disease Source Type: news

The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma Cruzi infection in CD‐1 mice
This article is protected by copyright. All rights reserved.
Source: Diabetes/Metabolism Research and Reviews - January 1, 2015 Category: Endocrinology Authors: Wunnie Brima, Daniel J. Eden, Syed Faizan Mehdi, Michelle Bravo, Mohammad M. Wiese, Joanna Stein, Vanessa Almonte, Dazhi Zhao, Irwin Kurland, Jeffrey E. Pessin, Tomas Zima, Herbert B. Tanowitz, Louis M. Weiss, Jesse Roth, Fnu Nagajyothi Tags: Research Article Source Type: research

Saturated fat link with heart disease questioned
This article is one doctor's opinion based on his own knowledge, research and experience. However, it is fair to say there is an ongoing debate about how far cholesterol is a risk factor for heart disease, especially in people who are otherwise healthy. There is also a similar debate about the use of statins in people who have no evidence of cardiovascular disease. This is alongside ongoing research into the components of LDL and the different types of lipoproteins known to increase risk the most. None of this relevant new evidence is covered by the news reporting.   What should you eat? There is no need to change curren...
Source: NHS News Feed - October 23, 2013 Category: Consumer Health News Tags: Heart/lungs Food/diet QA articles Source Type: news

Benefits & risks of statin therapy for primary prevention of cardiovascular disease in Asian Indians - A population with the highest risk of premature coronary artery disease & diabetes.
Benefits & risks of statin therapy for primary prevention of cardiovascular disease in Asian Indians - A population with the highest risk of premature coronary artery disease & diabetes. Indian J Med Res. 2013 Oct;138(4):461-91 Authors: Enas EA, Kuruvila A, Khanna P, Pitchumoni CS, Mohan V Abstract Several reviews and meta-analyses have demonstrated the incontrovertible benefits of statin therapy in patients with cardiovascular disease (CVD). But the role for statins in primary prevention remained unclear. The updated 2013 Cochrane review has put to rest all lingering doubts about the overwhelming ...
Source: The Indian Journal of Medical Research - October 1, 2013 Category: Biomedical Science Authors: Enas EA, Kuruvila A, Khanna P, Pitchumoni CS, Mohan V Tags: Indian J Med Res Source Type: research

As preschool obesity rates dip, Boston Children’s expert suggests feds step to the plate
The scales may not be tipping quite so precipitously for some low-income preschoolers. So says a new report from the Centers for Disease Control and Prevention (CDC). Nineteen states saw small decreases in obesity rates among preschoolers between 2008 and 2011, while rates held steady in another 20 states. Is this cause for celebration, cautious optimism or concern? Perhaps all of the above, says David Ludwig, MD, PhD, director of the New Balance Foundation Obesity Prevention Center Boston Children’s Hospital. “The report is a small, but encouraging, sign after nearly half a century of bad news.” The latest data...
Source: Thrive, Children's Hospital Boston - September 11, 2013 Category: Pediatrics Authors: Lisa Fratt Tags: All posts Childhood obesity Children's in the news Health & wellness Healthful eating Research David Ludwig New Balance Foundation Obesity Prevention Center Source Type: news

Recent advances in the epidemiology, outcome, and prevention of myocardial infarction and stroke in sub-Saharan Africa
The early part of the new millennium witnessed reports of a growing burden of cardiovascular disease in Sub-Saharan Africa (SSA). However the contribution of ischemic heart disease and stroke to this increasing burden relative to that caused by hypertensive heart disease, cardiomyopathy and rheumatic heart disease was not clear. Over the last decade, data from the continent has begun to clarify this issue and suggests three main points. The burden of ischemic heart disease relative to other causes of heart disease remains low particularly in the black Africans majority. Stroke caused predominantly by hypertension is now a ...
Source: Heart - August 2, 2013 Category: Cardiology Authors: Ntsekhe, M., Damasceno, A. Tags: Drugs: cardiovascular system, Hypertension, Acute coronary syndromes, Epidemiology Global burden of cardiovascular disease Source Type: research

MicroRNAs In Arterial Hypertension.
Abstract Arterial hypertension is an epidemic currently affecting almost a billion people worldwide. The consequences from high blood pressure vary, from peripheral arterial disease and chronic kidney failure to acute myocardial infarction and stroke. MicroRNAs (miRNAs) are small non-coding RNA molecules comprised of 22-26 nucleotides and provide post-transcriptional protein expression regulation. The many biological processes in which they are implicated, such as cell proliferation, apoptosis, metabolism, cell differentiation and morphogenesis confirms the functional significance of miRNAs. It has been found that...
Source: Current Topics in Medicinal Chemistry - May 31, 2013 Category: Chemistry Authors: Synetos A, Toutouzas K, Stathogiannis K, Latsios G, Tsiamis E, Tousoulis D, Stefanadis C Tags: Curr Top Med Chem Source Type: research

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