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Antibodies to Human Herpesviruses and Rate of Incident Cardiovascular Events and All-Cause Mortality in the UK Biobank Infectious Disease Pilot Study
CONCLUSIONS: In this mostly White UK Biobank subset, neither HHV seropositivity nor titers were associated with stroke/MI or all-cause mortality.PMID:35873304 | PMC:PMC9301583 | DOI:10.1093/ofid/ofac294
Source: Herpes - July 25, 2022 Category: Infectious Diseases Authors: Petrina Chu Sharon Louise Cadogan Charlotte Warren-Gash Source Type: research

TAT-RHIM: a more complex issue than expected
Biochem J. 2022 Jan 11:BCJ20210677. doi: 10.1042/BCJ20210677. Online ahead of print.ABSTRACTMurine cytomegalovirus protein M45 contains a RIP homotypic interaction motif (RHIM) that is sufficient to confer protection of infected cells against necroptotic cell death. Mechanistically, the N-terminal region of M45 drives rapid self-assembly into homo-oligomeric amyloid fibrils, and interacts with the endogenous RHIM domains of receptor-interacting protein kinases (RIPK) 1, RIPK3, Z-DNA binding protein 1, and TIR domain-containing adaptor-inducing interferon-β. Remarkably, all four mammalian proteins harbouring such a RHIM do...
Source: The Biochemical Journal - January 11, 2022 Category: Biochemistry Authors: Benedikt Kolbrink Theresa Riebeling Nikolas K Teiwes Claudia Steinem Hubert Kalbacher Ulrich Kunzendorf Stefan Krautwald Source Type: research

Title: Cytomegalovirus antibody levels and mortality among hospitalized elderly patients.
Conclusions: Increased IgG antibody levels against CMV are associated with increased short and long-term mortality in elderly hospitalized patients, especially in the patients without cardiovascular disease. PMID: 32803995 [PubMed - as supplied by publisher]
Source: Annals of Medicine - August 19, 2020 Category: Internal Medicine Tags: Ann Med Source Type: research

Presence of asymptomatic cytomegalovirus and Epstein--Barr virus DNA in blood of persons with HIV starting antiretroviral therapy is associated with non-AIDS clinical events
Background: Even with antiretroviral therapy (ART), persons with HIV (PWH) experience increased morbidity and mortality. Cytomegalovirus (CMV) and Epstein--Barr virus (EBV) co-infections likely exacerbate inflammatory-related diseases. Objective: To determine if presence of detectable CMV or EBV DNA in peripheral blood mononuclear cells (PBMC) is associated with non-AIDS events among PWH receiving modern ART. Design: We performed a case--control study of PWH starting ART and HIV-suppressed at year 1 and thereafter, 140 cases who experienced non-AIDS events and 305 matched controls. Events included myocardial infarc...
Source: AIDS - April 9, 2020 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Cytomegalovirus Infection in Cardiovascular Diseases
AbstractAtherosclerosis underlies the development of many cardiovascular diseases that continue to hold a leading place among the causes of death in developed countries. The role of activated immune cells in atherosclerosis progression has been convincingly demonstrated, but the mechanism of their action remains poorly investigated. Since atherosclerosis is associated with chronic inflammatory response, involvement of viral and bacterial infections in atherogenesis has been examined. A special place among the infectious agents is held by human herpesviruses as the most common persistent viruses in human population coupled ...
Source: Biochemistry (Moscow) - December 1, 2018 Category: Biochemistry Source Type: research

Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction.
CONCLUSIONS: Our study supports linear correlations between CIMT and IC and hs-CRP levels. However, these associations seem to depend on the type of vascular burden. PMID: 28051279 [PubMed - in process]
Source: Croatian Medical Journal - December 30, 2016 Category: Journals (General) Authors: Kurkowska-Jastrzebska I, Karlinski MA, Błazejewska-Hyzorek B, Sarzynska-Dlugosz I, Filipiak KJ, Czlonkowska A Tags: Croat Med J Source Type: research

CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
Summary Although chronic infection with cytomegalovirus (CMV) is known to drive T lymphocytes toward a senescent phenotype, it remains controversial whether and how CMV can cause coronary heart disease (CHD). To explore whether CMV seropositivity or T‐cell populations associated with immunosenescence were informative for adverse cardiovascular outcome in the very old, we prospectively analyzed peripheral blood samples from 751 octogenarians (38% males) from the Newcastle 85+ study for their power to predict survival during a 65‐month follow‐up (47.3% survival rate). CMV‐seropositive participants showed a higher pre...
Source: Aging Cell - December 22, 2015 Category: Cytology Authors: Ioakim Spyridopoulos, Carmen Martin‐Ruiz, Catharien Hilkens, Mohammad E. Yadegarfar, John Isaacs, Carol Jagger, Tom Kirkwood, Thomas Zglinicki Tags: Short Take Source Type: research