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Total 459 results found since Jan 2013.

Strategies for treatment of disease-associated dementia beyond Alzheimer disease: An update
Curr Neuropharmacol. 2022 Apr 11. doi: 10.2174/1570159X20666220411083922. Online ahead of print.ABSTRACTMemory, cognition, dementia, and neurodegeneration are complexly interlinked processes through various mechanistic pathways leading to a range of clinical outcomes. These are strongly associated with pathological conditions like Alzheimer's disease, Parkinson's disease, schizophrenia, stroke and are a growing concern for their timely diagnosis and management. Several cognition-enhancing interventions for management include non-pharmacological interventions like diet, exercise, and physical activity, while pharmacological...
Source: Current Neuropharmacology - April 12, 2022 Category: Drugs & Pharmacology Authors: Khan Sabiya Samim Gopal L Khatik Ashok K Datusalia Source Type: research

Inflammation-mediated vitamin K and vitamin D effects on vascular calcifications in people with HIV on active antiretroviral therapy
Background: People with HIV (PWH) experience increased systemic inflammation and monocyte activation, leading to increased risk of cardiovascular events (death, stroke, and myocardial infarction) and higher coronary artery calcium scores (CACs). Vitamins D and K2 have significant anti-inflammatory effects; in addition, vitamin K2 is involved in preventing vascular calcifications in the general population. The roles of vitamins D and K in increased coronary calcifications in successfully treated PWH is less understood. Methods: We prospectively recruited 237 PWH on antiretroviral treatment (ART) and 67 healthy co...
Source: AIDS - March 25, 2022 Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

Progressive Small-Vessel Strokes Following Antiretroviral Therapy in a Patient with Acquired Immunodeficiency Syndrome
The human immunodeficiency virus (HIV), which primarily infects CD4+ T-cells and microglia/macrophages, causes cognitive, memory-related, behavioral, and motor dysfunctions, collectively known as HIV-1-associated neurocognitive disease (HAND),1 which typically occurs among patients with chronic HIV/acquired immunodeficiency syndrome (AIDS) with low CD4+ T-cell levels and high plasma viral loads. The introduction of combinational antiretroviral therapy (cART) has significantly improved the survival rate and quality of life of patients with HIV/AIDS.
Source: Journal of Stroke and Cerebrovascular Diseases - March 2, 2022 Category: Neurology Authors: Tomoya Shibahara, Kuniyuki Nakamura, Daisuke Abe, Naoki Tagawa, Yoshinobu Wakisaka, Takanari Kitazono, Tetsuro Ago Tags: Case Report Source Type: research

ASA: BP Telemonitoring Aids Stroke Survivors in Underserved Areas
TUESDAY, Feb. 8, 2022 -- Remote blood pressure monitoring and telehealth visits improve outcomes for stroke survivors who live in historically under-resourced communities, according to a study presented at the American Stroke Association...
Source: Drugs.com - Pharma News - February 8, 2022 Category: Pharmaceuticals Source Type: news

Short Communication: Incidence and Risk Factors of Ischemic Stroke and Transient Ischemic Attack Among People Living with HIV: A Longitudinal Cohort Study
AIDS Research and Human Retroviruses,Volume 38, Issue 2, Page 131-134, February 2022.
Source: AIDS Research and Human Retroviruses - February 4, 2022 Category: Infectious Diseases Authors: Akarin Hiransuthikul Aurauma Chutinet Jiratchaya Sophonphan Sasiwimol Ubolyam Kiat Ruxrungtham Anchalee Avihingsanon Source Type: research

Assessing the characteristics and diagnostic value of plaques for patients with acute stroke using high-resolution magnetic resonance imaging
CONCLUSIONS: A larger plaque area and smaller LA in the stenotic MCA, and obvious plaque enhancement might indicate that a patient is prone to acute stroke.PMID:35111645 | PMC:PMC8739121 | DOI:10.21037/qims-21-531
Source: Atherosclerosis - February 3, 2022 Category: Cardiology Authors: Danfeng Zhang Mi Wang Lili Wu Ying Zhao Siyu Wang Xindao Yin Xinying Wu Source Type: research

Using a digital spelling aid to improve writing in persons with post-stroke aphasia: An intervention study
CONCLUSIONS & IMPLICATIONS: The study shows that a digital spelling aid constitutes effective support for people with aphasia and may also affect levels other than spelling. The training had a generalising positive effect on text writing and spelling in a test. Although writing difficulties is a persisting symptom in aphasia, it can be supported and improved through use of digital spelling aids. Hence, treatment of writing ability should always be included in the rehabilitation of people with aphasia.WHAT THIS PAPER ADDS: What is already known on this subject Use of a technical writing aid can have a positive impact on the...
Source: International Journal of Language and Communication Disorders - January 29, 2022 Category: Speech-Language Pathology Authors: Charlotte Johansson-Malmeling Malin Antonsson Åsa Wengelin Ingrid Henriksson Source Type: research

Tomato concentrate could help reduce chronic intestinal inflammation associated with HIV
New UCLA-led research in mice suggests that adding a certain type of tomato concentrate to the diet can reduce the intestinal inflammation that is associated with HIV. Left untreated, intestinal inflammation can accelerate arterial disease, which in turn can lead to heart attack and stroke.The findings provide clues to how the altered intestinal tract affects disease-causing inflammation in people with chronic HIV infection, suggesting that targeting the inflamed intestinal wall may be a novel way to prevent the systemic inflammation that persists even when antiviral therapy is effective in controlling a person ’s HIV.Th...
Source: UCLA Newsroom: Health Sciences - January 11, 2022 Category: Universities & Medical Training Source Type: news

Intracranial vascular imaging detects arterial wall abnormalities in persons with treated HIV infection
Conclusion: In persons at moderate-to-high cardiovascular risk, HIV infection, even when well controlled, may be associated with a greater burden of intracranial large artery disease and, specifically, of ICAD. Studies of the mechanisms underlying higher rates of ischemic stroke in PWH should include evaluation for intracranial large artery disease. VW-MRI provides added value as an adjunct to traditional luminal imaging when evaluating cerebrovascular risk in PWH.
Source: AIDS - December 14, 2021 Category: Infectious Diseases Tags: CLINICAL SCIENCE: CONCISE COMMUNICATIONS Source Type: research

Plasma galectin-9 as a predictor of adverse non-AIDS events in persons with chronic HIV during suppressive antiretroviral therapy
Background: People with HIV (PWH) on antiretroviral therapy (ART) still experience an increased risk of morbidity and mortality, presumably driven by chronic inflammation, yet predictors of discrete or combinatorial outcomes remain unclear. Galectin-9 (Gal-9), a driver of both inflammatory and immunosuppressive responses, has been associated with HIV disease progression and multimorbidity. Objective: To determine whether plasma Gal-9 levels are associated with the occurrence of specific non-AIDS events (NAEs) in PWH initiating ART. Design: We performed a nested case–control study of PWH enrolled from 20...
Source: AIDS - November 23, 2021 Category: Infectious Diseases Tags: CLINICAL SCIENCE: CONCISE COMMUNICATION Source Type: research

Incidence and Risk Factors of Ischemic Stroke and Transient Ischemic Attack Among People Living with HIV: A Longitudinal Cohort Study
AIDS Research and Human Retroviruses, Ahead of Print.
Source: AIDS Research and Human Retroviruses - November 17, 2021 Category: Infectious Diseases Authors: Akarin Hiransuthikul Aurauma Chutinet Jiratchaya Sophonphan Sasiwimol Ubolyam Kiat Ruxrungtham Anchalee Avihingsanon Source Type: research