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Total 234 results found since Jan 2013.

The relationship of platelet-to-lymphocyte ratio with clinical outcome and final infarct core in acute ischemic stroke patients who have undergone endovascular therapy.
In this study we aimed to evaluate whether the PLR had a prognostic role in stroke patients undergoing thrombectomy and attempted to determine the effect that this ratio had on their survival. METHODS: Over a three-year period, demographic, clinical, and angiographic findings of 57 consecutive patients with acute ischemic stroke who underwent mechanical thrombectomy were evaluated. RESULTS: The patients were divided into two groups on the basis of a PLR level cut-off value of 145 based on receiver operating characteristic (ROC) curve. Successful revascularization (mTICI 2b and 3) was achieved in 42 of 57 (73.7%) pa...
Source: Neurological Research - August 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between Leukoaraiosis and Poor Outcome is not due to Reperfusion Inefficiency after Intravenous Thrombolysis
Abstract Leukoaraiosis (LA) is associated with structural and functional cerebrovascular impairment, which may compromise the capacity of ischemic tissue to maximize reperfusion after intravenous thrombolysis (IVT). We aimed to determine whether severe LA is correlated with reperfusion inefficiency, which contributes to infarct growth and poor functional outcome. We analyzed data from our consecutive acute ischemic stroke (AIS) patients who had acquired baseline and 24-h follow-up diffusion- and perfusion-weighted imaging. Reperfusion was defined as reduction of ≥70 % of hypoperfusion lesion at 24 h from basel...
Source: Translational Stroke Research - June 1, 2016 Category: Neurology Source Type: research

Effective management of patients with acute ischemic stroke based on lean production on thrombolytic flow optimization
In this study, we aimed to determine whether applying lean principles to flow optimization could hasten the initiation of thrombolysis. A multidisciplinary team (Stroke Team) was organized to implement an ongoing, continuous loop of lean production that contained the following steps: decomposition, recognition, intervention, reengineering and assessment. The door-to-needle time (DNT) and the percentage of patients with DNT ≤ 60 min before and after the adoption of lean principles were used to evaluate the efficiency of our flow optimization. Thirteen patients with AIS in the pre-lean period and 43 patients with AIS in...
Source: Australasian Physical and Engineering Sciences in Medicine - April 18, 2016 Category: Biomedical Engineering Source Type: research

Women have a poorer very long-term functional outcome after stroke among adults aged 18–50 years: the FUTURE study
In conclusion, 14 years after an ischemic cerebrovascular event in young adults, one out of five IS survivors and one out of ten TIA survivors is still dependent in daily life, with a two to threefold higher risk of a poor outcome in women. This includes a period of life, during which important decisions regarding work and family life have to be made.
Source: Journal of Neurology - April 1, 2016 Category: Neurology Source Type: research

The stroke east Saxony pilot project for organized post‐stroke care: a case–control study
ConclusionsOur pilot data suggest that organized post‐stroke care enhances achievement of secondary prevention goals. Its possible effect on stroke recurrence, long‐term disability, and quality of life is currently investigated in a prospective cohort study. The Stroke East Saxony Pilot Project for Organized Post‐Stroke Care was case–control study to explore the feasibility of a self‐developed standardized post‐stroke pathway and its impact on secondary stroke prevention and long‐term outcome in patients with acute stroke. These pilot data suggest that organized post‐stroke care enhances achievement of sec...
Source: Brain and Behavior - March 31, 2016 Category: Neurology Authors: Ulf Bodechtel, Kristian Barlinn, Uwe Helbig, Katrin Arnold, Timo Siepmann, Lars‐Peder Pallesen, Volker Puetz, Heinz Reichmann, Jochen Schmitt, Jessica Kepplinger Tags: Original Research Source Type: research

Severe Cerebral Venous and Sinus Thrombosis: Clinical Course, Imaging Correlates, and Prognosis
Conclusion The outcome of severe CVT is almost equally divided between severe impairment or death and survival with no or only mild handicap. Specifically, space-occupying mass effect and associated neurologic deterioration seem to determine a poor outcome. Therefore, early detection and treatment of mass effect should be the focus of critical care.
Source: Neurocritical Care - March 20, 2016 Category: Neurology Source Type: research

Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke.
CONCLUSIONS: Plasma miR-124-3p and miR-16 are molecular markers which could be useful for the early prediction of mortality and mRS. PMID: 26968104 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - March 9, 2016 Category: Biochemistry Authors: Rainer TH, Leung LY, Chan CP, Leung YK, Abrigo JM, Wang D, Graham CA Tags: Clin Biochem Source Type: research

First-line lesional aspiration in acute stroke thrombectomy using a novel intermediate catheter: Initial experiences with the SOFIA.
CONCLUSIONS: Lesional aspiration with SOFIA is in line with published data. The SOFIA may be used as a first-line device, aiming at fast recanalization by sole aspiration with good safety and efficacy. If unsuccessful, it converts into part of a stent retriever-based multimodality treatment. PMID: 26908589 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - February 26, 2016 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Severity and outcomes according to stroke etiology in patients under 50 years of age with ischemic stroke
Abstract To analyze the association of stroke etiological subtypes with severity and outcomes at 3 and 12 months in patients ≤50 years. Observational study of patients admitted to a stroke unit (2007–2013). Variables: demographic data, vascular risk factors, comorbidities, severity on admission (NIHSS), and good functional outcome (mRS ≤ 1) at 3 and 12 months. We used multivariate analyses to evaluate the influence of stroke etiology on severity and outcomes. We included 214 patients, 58.3 % men, mean age 41.4 years. General linear models showed all etiologies were more severe than lacunar strokes (P...
Source: Journal of Thrombosis and Thrombolysis - February 5, 2016 Category: Hematology Source Type: research

Homocysteine-lowering therapy and early functional outcomes of ischemic patients with H-type hypertension: a retrospective analysis of CNSR
This study evaluated the effects of HLT during hospitalization on the early outcomes of the 792 ischemic stroke patients with H-type hypertension from the China National Stroke Registry. The subjects were divided into HLT and non-HLT groups. Demographic and laboratory information were collected, while the functional outcome at discharge and at 90 days follow-up were assessed by National Institutes of Health Stroke Scale and modified Rankin Scale (mRS) in both groups. We found that in the univariate analysis, the proportions of patients with good functional outcomes (mRS = 0–2) were 31.68 versus 29.36 % (OR 0.90, 95 ...
Source: Australasian Physical and Engineering Sciences in Medicine - December 7, 2015 Category: Biomedical Engineering Source Type: research

Development of a decision analytic model to support decision making and risk communication about thrombolytic treatment
Conclusions: We have produced a DAM that provides an estimation of the likely benefits and risks of thrombolysis for individual patients, which has subsequently been embedded in a computerised decision aid to support better decision-making and informed consent.
Source: BMC Medical Informatics and Decision Making - November 11, 2015 Category: Information Technology Authors: Peter McMeekinDarren FlynnGary FordHelen RodgersJo GrayRichard Thompson Source Type: research

Stent-based thrombectomy versus intravenous tissue plasminogen activator in acute ischaemic stroke: A systematic review and meta-analysis.
CONCLUSION: Stentrievers can achieve a high rate of recanalisation and functional independence in acute ischaemic stroke and have a relatively good safety profile. Our meta-analysis demonstrates a clear benefit of an intra-arterial mechanical approach vs standard treatment. PMID: 26490828 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - October 23, 2015 Category: Radiology Tags: Interv Neuroradiol Source Type: research

Healthcare circuits and functional outcomes 3 and 12 months after a stroke in a population-based cohort of 929 patients
In this study, carried out with an exhaustive population within a region and a one-year follow-up with few missing data, the results show a morbi-mortality after stroke higher than the one reported in previous studies. The results also confirm the better prognosis of IS.
Source: Annals of Physical and Rehabilitation Medicine - October 2, 2015 Category: Rehabilitation Source Type: research

Computed tomography perfusion-based thrombolysis in wake-up stroke
Abstract Wake-up stroke (WUS) patients are typically excluded from reperfusion treatment, as the time of symptoms onset is unknown. The purpose of this study is to evaluate the clinical outcome and safety of intravenous thrombolysis with rt-PA in patients with WUS eligible for therapy using computed tomography perfusion criteria (CTP), compared to patients treated with rt-PA within 4.5 h of symptoms onset (non-WUS). This is an experimental, open-label trial, controlled against the best therapy currently in use. Primary endpoints were functional independence after 3 months [modified Rankin scale (mRS) ≤ 1] ...
Source: Internal and Emergency Medicine - September 14, 2015 Category: Emergency Medicine Source Type: research

Thrombectomy assisted by carotid stenting in acute ischemic stroke management: benefits and harms
This study assesses the benefits and harms of thrombectomy assisted by carotid stenting and identifies factors associated with clinical outcome and procedural complications. Retrospective single-center analysis of 47 consecutive stroke patients with carotid occlusion or high-grade stenosis and concomitant intracranial embolus treated between September 2011 and December 2014. Benefits included early improvement of stroke severity (NIHSS ≥ 10) or complete remission within 72 h and favorable long-term outcome (mRS ≤ 2). Harms included complications during and following EVT. Mean age was 64.3 years (standard deviatio...
Source: Journal of Neurology - September 7, 2015 Category: Neurology Source Type: research