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Source: European Respiratory Journal

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Total 303 results found since Jan 2013.

Left ventricular systolic torsion is correlated to right ventricular dilation in pulmonary hypertension patients
Conclusion: We concluded that left ventricular torsion which plays a key role in left ventricular systolic function and stroke volume is affected in PH patients with MPAP higher than 35 mmHg and is correlated to right ventricular dilation.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Lamia, B., Molano, L. C., Cuvelier, A., Viacroze, C., Muir, J.-F. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Hemodynamic response on sleep disordered breathing in obese subjects: Differences between N2 and REM stage
Conclusion: Our results demonstrate that the combination of IH and reduced mean oxygen saturation but not IH alone is associated with increased BPvalues during sleep bothN2 andREM sleep. A novel finding is the fact, that patients with this combination show an increased cardiac output at least in N2sleep.These results will have to be confirmed by a higher number of included patients.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Grencho, D., Staats, R., Pereira, C., Fernandes, D., Moreira, S. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Doppler echocardiographic evaluation of hemodynamic effects of applying bilevel positive airway pressure
Conclusion: The cardiopulmonary and interventricular repercussions by echocardiography, were expressed by reducing the left ventricular preload and increasing the biventricular preload, stroke volume, and cardiac output, ensuring increased tidal volume and blood oxygenation.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Vinhal, G., Prates, B., Cunha, T., Silva, L., Araujo, L., Melo, D., Lopes, C. Tags: 2.2 Noninvasive Ventilatory Support Source Type: research

Effect of riociguat on pulmonary arterial compliance (PAC) in patients with PAH in PATENT-1
Conclusions: In PATENT-1, riociguat significantly improved pulmonary artery stiffness in pts with PAH. Improvements in PAC correlated with improvements in pulmonary hemodynamics. n¹Riociguat 2.5 mg–maxPlaceboLS mean difference from baseline to Week 12 (95% CI)p-valueBaselineWeek 12BaselineWeek 12PAC, mL/mmHg227/1081.5±0.81.9±1.21.4±1.01.4±0.9+0.44 (0.26 to 0.62)<0.0001SAC, mL/mmHg223/1071.2±0.51.6±0.61.2±0.61.4±0.7+0.18 (0.07 to 0.30)0.0013Data are mean±SD unless otherwise indicated; ¹riociguat 2.5 mg–max/placebo.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Preston, I., Al-Naamani, N., Ghio, S., Ghofrani, H.-A., Hassoun, P., Nikkho, S., Fritsch, A., Torbicki, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Apelin improves cardiac output in patients with pulmonary arterial hypertension
Conclusion: Acute apelin administration in patients with PAH led to an improvement in cardiac output and pulmonary vascular resistance. APJ agonism may be a useful therapeutic target for treatment of PAH.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Brash, L., Barnes, G., Brewis, M., Church, C., Gibbs, S., Howard, L., Johnson, M., McGlinchey, N., Simpson, J., Stirrat, C., Thomson, S., Watson, G., Welsh, D., Wilkins, M., Newby, D., Peacock, A. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Left ventricular-arterial coupling and cardiac remodeling in patients with idiopathic arterial pulmonary hypertension
Conclusions: The reduction of LVAC as the key feature of right heart remodeling was observed in patients with IPAH with dilated RV and decreased right ventricular ejection fraction.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Dadacheva, Z., Belevskaya, A., Saidova, M., Martynyuk, T., Chazova, I. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

OSA results in nocturnal cerebral hypoxia which is prevented by CPAP - Data from a randomised controlled trial
Conclusions: CPAP therapy withdrawal – and thus recurrence of OSA – results in intermittent and sustained nocturnal cerebral tissue deoxygenation to a degree reported to cause functional impairment. These findings suggest that patients with untreated OSA are at increased risk of nocturnal cerebral damage, a threat than can be prevented by CPAP therapy.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Schwarz, E. I., Furian, M., Schlatzer, C., Stradling, J. R., Kohler, M., Bloch, K. E. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Hemodynamic effects of continuous positive airway pressure as assessed by doppler echocardiography
Conclusions: Continuous positive airway pressures of 10 and 15 cm H2O generated reductions in right ventricular preload without changing either left ventricular preload or left ventricular afterload. There was also a decrease in cardiac output due to a reduction in heart rate. A strong correlation was observed between the mitral velocity-time integral and both stroke volume and cardiac output.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Vinhal, G., Cunha, T., Silva, L., Araujo, L., Melo, D., Lopes, C. Tags: 2.2 Noninvasive Ventilatory Support Source Type: research

Hemodynamic profiles in patients with chronic thromboembolic disease before and after pulmonary endarterectomy
Conclusions: Our observations point to an abnormal pulmonary vascular response to exercise and a decreased ventilatory efficiency as mechanisms underlying the exercise limitation observed in CTE patients. PEA resulted in improvements in circulatory responses indicative for an improved stroke volume response upon exercise and ventilatory efficiency.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Van Kan, C., Van der Plas, M., Reesink, H., Van Steenwijk, R., Tepaske, R., Kloek, J., Bresser, P. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Unemployment in COPD: Results from the BOLD study
Conclusion: There was substantial variation in employment of COPD-patients, but the overall effect of COPD on unemployment was modest when we adjusted for geography, demographic factors and comorbidities.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Gronseth, R., Erdal, M., Tan, W. C., Gislason, T., Juvekar, S. K., Salvi, S., Koul, P. A., Hafizi, H., Vollmer, W. M., Studnicka, M., Obaseki, D., Buist, A. S., Johannessen, A. Tags: 6.1 Epidemiology Source Type: research

Multimorbidity is a risk factor for obstructive sleep apnea-hypopnea syndrome in ageing
Conclusion: This study suggests that the coexistence of chronic comorbid diseases is associated with a higher risk for OSAHS in elderly primary care patients.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Kleisiaris, C., Kritsotakis, E., Daniil, Z., Malli, F., Markakis, G., Papathanasiou, I., Gourgoulianis, K. Tags: 4.2 Sleep and Control of Breathing Source Type: research

The comparison of serum visfatin levels in patients with acute PTE and non-PTE independent of BMI
Conclusions: Although the serum visfatin levels were lower in the acute PTE group than in the non-PTE group both of which had similar BMI, the difference was not statistically significant. Further and larger studies are needed to evaluate the visfatin levels in acute PTE.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Tutar, N., Dogan, S., Buyukoglan, H., Sen, A., Yilmaz, I., Yildirim, A., Dogan, A., Yetkin, A., Oymak, F. s., Gulmez, I., Demir, R. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

What's the role of stroke volume and cardiac output during exercise in cystic fibrosis?
Conclusion: we found lower SV and CO at rest and an attenuated increment of those parameters during exercise in GrB compared to GrA and GrC.Alterated conditions in GrB could be due to higher values of SVR, reduced physical activity and worse nutritional status.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Favoriti, A., Lambiase, C., Cimino, G., Versacci, P., D'Alu, V., Montanile, F., Rizzo, V., Lanzano, R., Ricupito, F., Tancredi, G. Tags: 7.3 Cystic Fibrosis Source Type: research

Assessing the role of cerebral autoregulation during intrathoracic pressure changes by near infrared spectroscopy (NIRS)
Changes in intrathoracic pressure in obstructive sleep apnea have strong intermittent effects on oxygenation of hemoglobin and left ventricular stroke volume. While compensatory systemic mechanisms are well studied the role of cerebral autoregulation remains essentially unknown. We aimed to compare hemodynamic response in muscle and brain assessed by NIRS during Valsalva- and Müller- maneuvers (VM respectively MM) and thereby describing the role of cerebral autoregulation.In five healthy adults cerebral and muscular NIRS and esophageal pressure (EP) were continuously measured during normal breathing, two VM (EP +15...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Laures, M., Bolz, N., Zhang, Z., Mensen, A., Schmidt, C., Khatami, R. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Phenotyping comorbidity in obstructive sleep apnea syndrome
Conclusion: Five distinct phenotypes of OSAS and its comorbidities were identified. Mapping the heterogeneity of OSAS may help identify at-risk groups early; Finally, determining predictors of comorbidity for the moderate and severe strata of these phenotypes implies a need to evaluate these factors when considering treatment options.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Vavougios, G., Natsios, G., Pastaka, C., Zarogiannis, S., Gourgoulianis, K. Tags: 4.2 Sleep and Control of Breathing Source Type: research