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Source: European Respiratory Journal

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Total 303 results found since Jan 2013.

The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in Sri Lanka:outcome of the BOLD study
Conclusion: The prevalence of COPD in Sri Lankan adults is similar to global and regional prevalences.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Amarasiri, L., Gunasinghe, W., Sadikeen, A., Fernando, A., Madegedara, D., Wickramasinghe, R., Gunasekera, K. Tags: Epidemiology Source Type: research

Risk of stroke in COPD: a matched cohort study
Conclusion: Relative to matched controls, people with COPD are at increased risk of stroke; however, this increased risk declines with age. Relative risks have not changed significantly during the study period, suggesting more research is needed to establish how stroke risk in COPD can be mitigated.References1. Annals ATS. In press.2. BMJ Open, 2014.4(7):e005540.Fig. 1 HRs for stroke stratified by a) age and b) time in COPD relative to sex- and GP-practice-matched COPD-free patients
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Morgan, A., Rothnie, K., Bhaskaran, K., Smeeth, L., Quint, J. Tags: Epidemiology Source Type: research

Long-term outcomes of percutaneous coronary intervention in patients with chronic obstructive pulmonary disease: a 13-year nationwide cohort study
Chronic obstructive pulmonary disease (COPD) is associated with increased risk of coronary atherosclerosis. However, its impact on the long-term outcomes in patients undergoing percutaneous coronary intervention (PCI) has not been described. Using the National Health Insurance Research Database of Taiwan, we identified 215275 adult patients who underwent first-time PCI between 2000 and 2012. Among them, the outcomes of patients with COPD (n = 24900) and without COPD (n = 190375) were compared. Baseline demographics and 13-year overall mortality and adverse cardiac outcomes after PCI (i.e., ischemic events, repeat revascula...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Lin, W.-C., Chen, C.-W., Lai, C.-H. Tags: Epidemiology Source Type: research

A case control study:The role of leukotriene receptor antagonist in cardiovascular risk
Conclusions: The results do not show a reduction of the MI risk in patients using a LTRA; situation somehow different in IS patients from primary health care centers with a slightly protective effect of montelukast in reducing the IS risk, that, however, did not reach statistical significance. Future studies should require a larger sample size and monitor asthmatic patients from primary care.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Hoxha, M., Malaj, V., Rovati, G., Messler, M. V., Doce, C. R., Cavanillas, A. B. Tags: Airway Pharmacology and Treatment Source Type: research

Comparison of clinical features and outcome in COPD patients with and without heart failure, admitted at tertiary care hospital
Conclusion: COPD with HF most likely presented with breathlessness and cough, with longer hospital stay and were more prone to arrhythmias as compared to COPD without HF.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Ashraf, S., Ashraf, A. Tags: Monitoring Airway Disease Source Type: research

Left ventricular strain and dyssynchrony by CMR Feature tracking in Idiopathic Pulmonary Arterial Hypertension(IPAH)
Conclusion: Impaired LV longitudinal strain and intraventricular dyssynchrony appear in IPAH. In the setting of impaired longitudinal function, LVEF is maintained by circumferential contraction. In IPAH with impaired LVEF, circumferential strain is impaired in addition to longitudinal strain.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Jayasekera, G., Mangion, K., Crowe, T., Mackenzie, A., McComb, C., Johnson, M., Church, C., Berry, C., Radjenovic, A., Peacock, A. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Prognostic value of hemodynamics following treatment initiation in pulmonary arterial hypertension
Conclusions: Stroke volume index and right atrial pressure at first follow-up catheterization were the best hemodynamic predictors of death or transplantation. These variables should be further validated as treatment targets in a prospective study.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Weatherald, J., Adir, Y., Boucly, A., Savale, L., Simonneau, G., Montani, D., Jaïs, X., Humbert, M., Chemla, D., Sitbon, O., Herve, P. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Left ventricular volume and wall stress are linked to lung function impairment in COPD
Conclusion: For the first time, we have shown a robust, repeatable relationship between lung function and LV wall stress in COPD, cross-sectionally and over 18 months. These findings support the hypothesis that the development of LV impairment in COPD could be initiated or promoted by mechanical factors exerted by the lung. Although the clinical implications of this finding are currently unclear, it would be sensible to monitor echocardiographic changes in COPD.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Alter, P., Jörres, R., Watz, H., Welte, T., Gläser, S., Schulz, H., Bals, R., Biertz, F., Wouters, E., Vestbo, J., Young, D., Vogelmeier, C. Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Cardiovascular comorbidity in Danish patients with scleroderma-associated interstitial lung disease
Conclusion: CC was frequent among patients with SSc-ILD but was not associated with increased mortality. As expected, PH was associated with severe excess mortality.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Madsen, G. A., Hyldgaard, C., Bendstrup, E. Tags: Diffuse Parenchymal Lung Disease Source Type: research

Hemodynamic effects of incremental dynamic hyperinflation
Dynamic hyperinflation (DH) is common in COPD and is often associated with exertional dyspnea. However, there is increasing evidence that DH may also impair hemodynamics via adverse cardiopulmonary interaction, though the mechanisms responsible remain unclear. As such, we examined the effect of incremental DH on left ventricular (LV) filling and ejection, and the role of direct ventricular interaction (DVI). We hypothesized that increasing DH would reduce LV end diastolic volume (LVEDV) and stroke volume (LVSV) due to DVI. 23 healthy subjects were randomly exposed to varying degrees of expiratory loading to induce DH such ...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Cheyne, W. S., Gelinas, J., Harp, L., Eves, N. D. Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Change in pulmonary function and cardiorespiratory fitness following chemotherapy in testicular cancer patients - a pilot study
Conclusions: There was a substantial reduction in VO2max after BEP corresponding to three decades of physiological aging. This reduction may reflect a decrease in the patients’ cardiac function and oxygen carrying capacity, and not to reduced DLco.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Edvardsen, E., Larsen, K.-O., Fossa, S. D., Ikdahl, T., Loge, J. H., Thorsen, L. Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Effect of riociguat on pulmonary arterial compliance in patients with pulmonary arterial hypertension (PAH) in the RESPITE study
Conclusion: In RESPITE, riociguat improved PAC in patients with PAH who had transitioned from PDE5i. The increase in PAC was more pronounced in patients whose exercise and functional capacity had also improved by Week 24.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Hoeper, M. M., Corris, P. A., Ghofrani, H.-A., Klinger, J. R., Langleben, D., Naeije, R., Simonneau, G., Jansa, P., Rosenkranz, S., Grünig, E., Scelsi, L., Meier, C., Busse, D., Benza, R. L. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Characterization of sociodemographic and health characteristics of USA adults with frequent respiratory symptoms
Conclusion: Our population-based data provides insight into relationships among frequent respiratory symptoms, chronic diseases, and sociodemographics.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Pleasants, R., Heidari, K., Ohar, J., Lugogo, N., Donohue, J., Strange, C., Mannino, D. Tags: Epidemiology Source Type: research

Intraoperative extracorporeal membrane oxygenation versus cardiopulmonary bypass for lung transplantation: A meta-analysis
Conclusion: ECMO support for LuTx showed better clinical outcomes compared to CPB.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Magouliotis, D., Svokos, A., Svokos, K., Olland, A., Massard, G., Tasiopoulou, V., Zacharoulis, D. Tags: Transplantation Source Type: research

Lower body positive pressure effects on cardiorespiratory response to submaximal running exercise
Anti-gravity treadmills facilitate locomotion by supporting body weight (BW) with lower body positive pressure (LBPP). Effects on cardiorespiratory regulation are unknown. Healthy men stood upright (n=11) and ran (n=9) at 9, 11, 13 and 15 km.h–1 (5 min stages) at LBPP (0, 15, 40 mmHg, corresponding to 0, 26±1 and 69±3 %BW support, respectively). Cardiac output (CO), stroke volume (SV), heart rate (HR), blood pressure (BP), peripheral resistance (PR) and oxygen uptake (VO2) were monitored. During standing, LBPP within seconds transiently increased SV (by 28.8±11.1 (+41%) and 42.4±13.9 (+60%...
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Uva, B., Stucky, F., Kayser, B. Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research