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Source: European Respiratory Journal
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Total 303 results found since Jan 2013.
In-vitro modeling of micro-emboli and their effect on microvascular circulation and endothelium mechanics
The objective of our study was to model embolization in microvasculature on a chip and study the biomechanical response.Methods: we used two cellular types, the established Human Umbilical Vein Endothelial Cells (HUVEC) and lung-specific Human Pulmonary Artery Endothelial Cells (HPAEC) to create self-organized microvasculature in microfluidics chips. We diluted carboxylated micro-beads (~5 mm) perfusing them with a controlled pressure head, visualizing flow in real-time with nano-tracers of distinct fluorescence. We perfused them sequentially, before and after embolization, during a 3D confocal image acquisition, while acq...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Piccari, L., Malandrino, A., Rodriguez, D. A., Sharpe, J. Tags: Pulmonary embolism Source Type: research
Aspiration risks factors, microbiology and empiric antibiotics for patients hospitalized with community-acquired pneumonia
Conclusions: Hospitalized patients with ACAP or CAP/AspRF+ had similar anaerobic flora compared to patients without AspRFs. Gram-negative bacteria were more prevalent in patients with severe ACAP. A large proportion of CAP patients received anti-anaerobic antibiotic coverage.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Marin Corral, J., Pascual Guardia, S., Amati, F., Aliberti, S., Masclans, J. R., Soni, N., Rodriguez, A., Sbila, O., Sanz, F., Sotgiu, G., Anzueto, A., Dimakou, K., Medenica, M., Petrino, R., Van De Garde, E., Restrepo, M. I. Tags: Respiratory infections Source Type: research
Quality control of cardiopulmonary exercise equipment
Conclusion: The metabolic simulator clearly identified devices that did not reliably measure V’E, V’O2 and/or V’CO2. We recommend verification with a metabolic simulator to become a routine part of the yearly quality check of exercise equipment.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Souren, T., De Bliek, E., Roeykens, J., De Soomer, K., Oostveen, E. Tags: Respiratory function technologists/scient. Source Type: research
REPAIR: long-term effects of macitentan on the right ventricle (RV) in pulmonary arterial hypertension (PAH)
Conclusions: Improvements in RV mass, volume and function observed with macitentan at Week 26 were maintained at Week 52. BL*Mean (SD)nBL to Week 26 change(95% CL)nBL to Week 52 change(95% CL)RVSV (mL)#52.2 (17.2)7112.0 (8.4, 15.6)||6312.0 (8.4, 15.6)||RV end diastolic vol (mL)149.8 (49.1)70–6.2 (–12.8, 0.4)§63–5.3 (–12.0, 1.4)§RV end systolic vol (mL)90.2 (40.6)70–16.1(–20.0, –12.2)63–17.0(–22.1, –12.0)RV ejection fraction (%)#37.7 (14.3)7010.6 (7.9, 13.3)629.5 (7.0, 12.0)RV mass (g)110.4 (47.5)70–10.5(–14.0, –7.1)63–9.2(–1...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kiely, D., Cottreel, E., Galie, N., Marcus, J. T., Peacock, A., Rosenkranz, S., Swift, A. J., Tawakol, A., Torbicki, A., Vonk Noordegraaf, A., Wetherill, G., Channick, R. Tags: Pulmonary hypertension Source Type: research
Sex differences in the relation between sex hormones and right ventricular function in pulmonary arterial hypertension
Conclusion: Patients with PAH have lower DHEAs and free testosterone concentrations than controls. Sex-based differences in the relation between DHEAs and RV function may have implications for sex hormone treatment in PAH.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: van Wezenbeek, J., Groeneveldt, J. A., Jansen, S. M. A., Heijboer, A. C., Goumans, M. J., Bogaard, H. J., Vonk Noordegraaf, A., De Man, F. S. Tags: Pulmonary embolism Source Type: research
Effect of obstructive sleep apnoea on cardiovascular outcomes in patients with acute coronary syndrome: a secondary analysis of the RICCADSA trial
Conclusions: OSA is an independent risk factor for MACCE in revascularized patients with ACS.Clinical trial registration: NCT00519597Funding: The Swedish Research Council, ResMed Foundation.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Peker, Y., Thunström, E., Glantz, H., Eulenburg, C. Tags: Sleep and control of breathing Source Type: research
Cardiovascular comorbidities based on impaired pulmonary function in non-smoking population
Conclusion: The prevalence of cardiovascular comorbidities in non-smokers was higher in restrictive group and COPD, compared to normal control. Restrictive group was independently associated with coronary artery disease in non-smokers.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Park, J. H., Park, J. E., Chung, W. Y., Hwang, S. C., Park, J. H., Park, B., Sung, L. K., Jung, Y.-J. Tags: Epidemiology Source Type: research
Iron bioavailability and cardiopulmonary function during ascent to very high altitude
More than one hundred million people reside worldwide at altitudes in excess of 2500 m above sea level. In the millions more who sojourn at high altitude for recreational, occupational or military pursuits, hypobaric hypoxia drives physiological changes affecting the pulmonary circulation, haematocrit and right ventricle (RV) [1]. Coincident with these, maximal left ventricular (LV) stroke volume (SV) falls [2], with a reduction of 20% reported after a 2-week stay at 4300 m [3]. A rise in heart rate (HR) compensates at rest and during submaximal exercise but is insufficient during maximal intensity exercise, cons...
Source: European Respiratory Journal - September 16, 2020 Category: Respiratory Medicine Authors: Holdsworth, D. A., Frise, M. C., Bakker-Dyos, J., Boos, C., Dorrington, K. L., Woods, D., Mellor, A., Robbins, P. A. Tags: Original Articles: Research letters Source Type: research
Cardiac function and pulmonary hypertension in Central Asian highlanders at 3250 m
The question addressed by the study
Chronic exposure to hypoxia increases pulmonary artery pressure (PAP) in highlanders, but the criteria for diagnosis of high-altitude pulmonary hypertension (HAPH) are debated. We assessed cardiac function and PAP in highlanders at 3250 m and explored HAPH prevalence using different definitions.
Patients and methods
Central Asian highlanders free of overt cardiorespiratory disease, permanently living at 2500–3500 m compared to age-matched lowlanders living <800 m. Participants underwent echocardiography close to their altitude of residence (at 3250 m versus ...
Source: European Respiratory Journal - August 19, 2020 Category: Respiratory Medicine Authors: Lichtblau, M., Saxer, S., Furian, M., Mayer, L., Bader, P. R., Scheiwiller, P. M., Mademilov, M., Sheraliev, U., Tanner, F. C., Sooronbaev, T. M., Bloch, K. E., Ulrich, S. Tags: Pulmonary vascular disease Original Articles: Pulmonary hypertension Source Type: research
EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke
Sleep disorders are highly prevalent in the general population and may be linked in a bidirectional fashion to stroke, which is one of the leading causes of morbidity and mortality.
Four major scientific societies established a task force of experts in neurology, stroke, respiratory medicine, sleep medicine and methodology, to critically evaluate the evidence regarding potential links and the impact of therapy. 13 research questions were evaluated in a systematic literature search using a stepwise hierarchical approach: first, systematic reviews and meta-analyses; second, primary studies post-dating the systematic reviews/...
Source: European Respiratory Journal - April 20, 2020 Category: Respiratory Medicine Authors: Bassetti, C. L. A., Randerath, W., Vignatelli, L., Ferini-Strambi, L., Brill, A.-K., Bonsignore, M. R., Grote, L., Jennum, P., Leys, D., Minnerup, J., Nobili, L., Tonia, T., Morgan, R., Kerry, J., Riha, R., McNicholas, W. T., Papavasileiou, V. Tags: Original Articles: EAN/ERS/ESO/ESRS statement Source Type: research
When it all comes down to pressure: right ventricular ejection fraction at cardiac catheterisation
In the present issue of the European Respiratory Journal, Heerdt et al. [1] report on the validation of right ventricularejection fraction (RVEF) calculated from a pressure curve at cardiac catheterisation. This is of great interest as right ventricular (RV) function is the main determinant of symptomatology and outcome in pulmonary hypertension [2], and RVEF accordingly adds significantly to risk stratification in these patients [3]. However, ejection fraction (EF) is a ratio of stroke volume (SV) to end-diastolic volume (EDV), with no pressure in the equation. So, how is it possible to calculate a volume ratio from pressure measurements?
Source: European Respiratory Journal - March 11, 2020 Category: Respiratory Medicine Authors: Naeije, R., Richter, M. J., Vanderpool, R., Tello, K. Tags: Editorials Source Type: research
The relationship between functional recovery and OSA in Stroke patients of a neurorehabilitation unit in Santiago, Chile
Conclusions: There was a moderate inverse correlation between the value of AHI and the change in FIM. Those patients who presented severity of OSA had less recovery.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Monge, G., Otto-Yanez, M., Torres-Castro, R., Oyarzo, D. Tags: Sleep and control of breathing Source Type: research
Benefits of early diagnosis and treatment of obstructive sleep Apnea-Hypopnea syndrome in patients with acute ischemic stroke: SASS (Sleep Apnea in Stroke patients Study)
Conclusions: Acute polygraphy is feasible in patients with AIS. Early treatment of OSAHS could improve stroke outcome, although larger multicentric studies are necessary to confirm these results
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Rodriguez Martin, P. J., Ferrer Galvan, M., Guerrero Zamora, P., Sanchez Gomez, J., Benitez Moya, J. M., Valido Morales, A. S. Tags: Sleep and control of breathing Source Type: research
Relationship between respiratory muscle strength and gait asymmetry in stroke patients
Conclusion: These data suggest that in stroke patients, increasing expiratory muscle strength and the improvement of gait asymmetry are closely related.
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Terui, Y., Sutoh, E., Iwasawa, S., Kikuchi, K., Furukawa, Y., Hasegawa, K., Uemura, S., Satake, M., Shioya, T. Tags: Rehabilitation and chronic care Source Type: research
Late Breaking Abstract - The effect of negative intrathoracic pressure and dynamic hyperinflation on heart-lung interaction during exercise
Increased negative intrathoracic pressure (nITP) and dynamic hyperinflation (DH) influence left ventricular (LV) filling and stroke volume (LVSV) at rest through changes in preload, afterload, and direct ventricular interaction (DVI). Whether nITP and DH influence LVSV expansion during exercise has not been studied. We investigated the hemodynamic effects of increased nITP alone and in combination with DH (nITP+DH) during constant-load cycling exercise (CLE). Participants (mean±SD: age=25±3yr, n=20, 10F:10M) performed CLE at 60% of supine maximal workload with a) inspiratory resistance of -20 cmH2O (nITP) and...
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Cheyne, W., Watson, A., Welykholowa, K., Eves, N. Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
