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Source: Cochrane Database of Systematic Reviews
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Total 466 results found since Jan 2013.
Early supported discharge services for people with acute stroke.
CONCLUSIONS: Appropriately resourced ESD services with co-ordinated multidisciplinary team input provided for a selected group of stroke patients can reduce long-term dependency and admission to institutional care as well as reducing the length of hospital stay. Results are inconclusive for services without co-ordinated multidisciplinary team input. We observed no adverse impact on the mood or subjective health status of patients or carers, nor on readmission to hospital.
PMID: 28703869 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 13, 2017 Category: General Medicine Authors: Langhorne P, Baylan S, Early Supported Discharge Trialists Tags: Cochrane Database Syst Rev Source Type: research
Interventions for improving modifiable risk factor control in the secondary prevention of stroke.
CONCLUSIONS: We found that organisational interventions may be associated with an improvement in achieving blood pressure target but we did not find any clear evidence that these interventions improve other modifiable risk factors (lipid profile, HbA1c, medication adherence) or reduce the incidence of recurrent cardiovascular events. Interventions, including patient education alone, did not lead to improvements in modifiable risk factor control or the prevention of recurrent cardiovascular events.
PMID: 29734470 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 7, 2018 Category: General Medicine Authors: Bridgwood B, Lager KE, Mistri AK, Khunti K, Wilson AD, Modi P Tags: Cochrane Database Syst Rev Source Type: research
Stem cell transplantation for ischemic stroke.
CONCLUSIONS: Overall, in participants with ischemic stroke, stem cell transplantation was associated with a reduced neurological impairment, but not with a better functional outcome. No obvious safety concerns were raised. However, these conclusions came mostly from small RCTs with high risk of bias, and the certainty of the evidence ranged from low to very low. More well-designed trials are needed.
PMID: 31055832 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 4, 2019 Category: General Medicine Authors: Boncoraglio GB, Ranieri M, Bersano A, Parati EA, Del Giovane C Tags: Cochrane Database Syst Rev Source Type: research
Anti-inflammatory therapy for preventing stroke and other vascular events after ischaemic stroke or transient ischaemic attack.
CONCLUSIONS: There is currently a paucity of evidence on the use of anti-inflammatory medications for prevention of major cardiovascular events following ischaemic stroke or TIA. RCTs are needed to assess whether use of anti-inflammatory medications in this setting is beneficial.
PMID: 32392374 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - May 10, 2020 Category: General Medicine Authors: Coveney S, McCabe JJ, Murphy S, O'Donnell M, Kelly PJ Tags: Cochrane Database Syst Rev Source Type: research
Pharmacological, psychological and non-invasive brain stimulation interventions for preventing depression after stroke.
CONCLUSIONS: The available evidence suggests that pharmacological interventions and psychological therapy may prevent depression and improve mood after stroke. However, there is very low certainty in these conclusions because of the very low-certainty evidence. More trials are required before reliable recommendations can be made about the routine use of such treatments after stroke.
PMID: 32390167 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - May 10, 2020 Category: General Medicine Authors: Allida S, Cox KL, Hsieh CF, House A, Hackett ML Tags: Cochrane Database Syst Rev Source Type: research
Citicoline for treating people with acute ischemic stroke.
CONCLUSIONS: This review assessed the clinical benefits and harms of citicoline compared with placebo or any other standard treatment for people with acute ischemic stroke. The findings of the review suggest there may be little to no difference between citicoline and its controls regarding all-cause mortality, disability or dependence in daily activities, severe adverse events, functional recovery and the assessment of the neurological function, based on low-certainty evidence. None of the included trials assessed quality of life and the safety profile of citicoline remains unknown. The available evidence is of low quality...
Source: Cochrane Database of Systematic Reviews - August 28, 2020 Category: General Medicine Authors: Martí-Carvajal AJ, Valli C, Martí-Amarista CE, Solà I, Martí-Fàbregas J, Bonfill Cosp X Tags: Cochrane Database Syst Rev Source Type: research
Motor imagery for gait rehabilitation after stroke.
CONCLUSIONS: We found very low-certainty evidence regarding the short-term benefits of MI on walking speed in individuals who have had a stroke, compared to other therapies. Evidence was insufficient to estimate the effect of MI on the dependence on personal assistance and walking endurance. Compared with other therapies, the evidence indicates that MI does not improve motor function and functional mobility after stroke (very low-certainty evidence). Evidence was also insufficient to estimate the effect of MI on gait, motor function, and functional mobility after stroke compared to placebo or no intervention. Motor Imagery...
Source: Cochrane Database of Systematic Reviews - September 23, 2020 Category: General Medicine Authors: Silva S, Borges LR, Santiago L, Lucena L, Lindquist AR, Ribeiro T Tags: Cochrane Database Syst Rev Source Type: research
Electromechanical-assisted training for walking after stroke.
CONCLUSIONS: People who receive electromechanical-assisted gait training in combination with physiotherapy after stroke are more likely to achieve independent walking than people who receive gait training without these devices. We concluded that eight patients need to be treated to prevent one dependency in walking. Specifically, people in the first three months after stroke and those who are not able to walk seem to benefit most from this type of intervention. The role of the type of device is still not clear. Further research should consist of large definitive pragmatic phase 3 trials undertaken to address specific quest...
Source: Cochrane Database of Systematic Reviews - October 22, 2020 Category: General Medicine Authors: Mehrholz J, Thomas S, Kugler J, Pohl M, Elsner B Tags: Cochrane Database Syst Rev Source Type: research
Insulin for glycaemic control in acute ischaemic stroke.
CONCLUSIONS: After updating the results of our previous review, we found that the administration of intravenous insulin with the objective of maintaining serum glucose within a specific range in the first hours of acute ischaemic stroke does not provide benefit in terms of functional outcome, death, or improvement in final neurological deficit and significantly increased the number of hypoglycaemic episodes. Specifically, those people whose glucose levels were maintained within a tighter range with intravenous insulin experienced a greater risk of symptomatic and asymptomatic hypoglycaemia than those people in the control ...
Source: Cochrane Database of Systematic Reviews - January 23, 2014 Category: Journals (General) Authors: Bellolio MF, Gilmore RM, Ganti L Tags: Cochrane Database Syst Rev Source Type: research
Interventions for improving modifiable risk factor control in the secondary prevention of stroke.
CONCLUSIONS: Pooled results indicated that educational interventions were not associated with clear differences in any of the review outcomes. The estimated effects of organisational interventions were compatible with improvements and no differences in several modifiable risk factors. We identified a large number of ongoing studies, suggesting that research in this area is increasing. The use of standardised outcome measures would facilitate the synthesis of future research findings.
PMID: 24789063 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 2, 2014 Category: Journals (General) Authors: Lager KE, Mistri AK, Khunti K, Haunton VJ, Sett AK, Wilson AD Tags: Cochrane Database Syst Rev Source Type: research
Haemodilution for acute ischaemic stroke.
CONCLUSIONS: The overall results of this review showed no clear evidence of benefit of haemodilution therapy for acute ischaemic stroke.These results are compatible with no persuasive beneficial evidence of haemodilution therapy for acute ischaemic stroke. This therapy has not been proven to improve survival or functional outcome.
PMID: 25159027 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 27, 2014 Category: Journals (General) Authors: Chang TS, Jensen MB Tags: Cochrane Database Syst Rev Source Type: research
Mailuoning for acute ischaemic stroke.
CONCLUSIONS: This review did not provide sufficient evidence to support the routine use of mailuoning for the treatment of people with acute ischaemic stroke. High-quality large-scale randomised controlled trials are needed to confirm the efficacy of mailuoning.
PMID: 25574904 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - January 9, 2015 Category: Journals (General) Authors: Yang W, Shi Z, Yang HQ, Teng J, Zhao J, Xiang G Tags: Cochrane Database Syst Rev Source Type: research
Interventions for post-stroke fatigue.
CONCLUSIONS: There was insufficient evidence on the efficacy of any intervention to treat or prevent fatigue after stroke. Trials to date have been small and heterogeneous, and some have had a high risk of bias. Some of the interventions described were feasible in people with stroke, but their efficacy should be investigated in RCTs with a more robust study design and adequate sample sizes.
PMID: 26133313 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 2, 2015 Category: Journals (General) Authors: Wu S, Kutlubaev MA, Chun HY, Cowey E, Pollock A, Macleod MR, Dennis M, Keane E, Sharpe M, Mead GE Tags: Cochrane Database Syst Rev Source Type: research
Puerarin for ischaemic stroke.
CONCLUSIONS: There is not enough evidence to evaluate the effect of puerarin on survival or dependency in people with ischaemic stroke. High quality and large-scale RCTs with long-term follow-up are needed to assess its efficacy.
PMID: 26891451 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 18, 2016 Category: Journals (General) Authors: Liu B, Tan Y, Wang D, Liu M Tags: Cochrane Database Syst Rev Source Type: research
Caregiver-mediated exercises for improving outcomes after stroke.
CONCLUSIONS: There is very low- to moderate-quality evidence that CME may be a valuable intervention to augment the pallet of therapeutic options for stroke rehabilitation. Included studies were small, heterogeneous, and some trials had an unclear or high risk of bias. Future high-quality research should determine whether CME interventions are (cost-)effective.
PMID: 28002636 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 20, 2016 Category: Journals (General) Authors: Vloothuis JD, Mulder M, Veerbeek JM, Konijnenbelt M, Visser-Meily JM, Ket JC, Kwakkel G, van Wegen EE Tags: Cochrane Database Syst Rev Source Type: research
