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Source: Cochrane Database of Systematic Reviews

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Total 466 results found since Jan 2013.

Trunk training following stroke
CONCLUSIONS: There is evidence to suggest that trunk training as part of rehabilitation improves ADL, trunk function, standing balance, walking ability, upper and lower limb function, and quality of life in people after stroke. Core-stability, selective-, and unstable-trunk training were the trunk training approaches mostly applied in the included trials. When considering only trials with a low risk of bias, results were mostly confirmed, with very low to moderate certainty, depending on the outcome.PMID:36864008 | DOI:10.1002/14651858.CD013712.pub2
Source: Cochrane Database of Systematic Reviews - March 2, 2023 Category: General Medicine Authors: Liselot Thijs Eline Voets Stijn Denissen Jan Mehrholz Bernhard Elsner Robin Lemmens Geert Saf Verheyden Source Type: research

Interventions for the uptake of evidence-based recommendations in acute stroke settings
CONCLUSIONS: We are uncertain whether a multifaceted implementation intervention compared to no intervention improves adherence to evidence-based recommendations in acute stroke settings, because the certainty of evidence is very low.PMID:37565934 | DOI:10.1002/14651858.CD012520.pub2
Source: Cochrane Database of Systematic Reviews - August 11, 2023 Category: General Medicine Authors: Elizabeth A Lynch Lemma N Bulto Heilok Cheng Louise Craig Julie A Luker Kathleen L Bagot Tharshanah Thayabaranathan Heidi Janssen Elizabeth McInnes Sandy Middleton Dominique A Cadilhac Source Type: research

Electromechanical-assisted training for walking after stroke.
CONCLUSIONS: People who receive electromechanical-assisted gait training in combination with physiotherapy after stroke are more likely to achieve independent walking than people who receive gait training without these devices. Specifically, people in the first three months after stroke and those who are not able to walk seem to benefit most from this type of intervention. The role of the type of device is still not clear. Further research should consist of a large definitive, pragmatic, phase III trial undertaken to address specific questions such as the following: What frequency or duration of electromechanical-assisted ...
Source: Cochrane Database of Systematic Reviews - July 25, 2013 Category: Journals (General) Authors: Mehrholz J, Elsner B, Werner C, Kugler J, Pohl M Tags: Cochrane Database Syst Rev Source Type: research

Antiepileptic drugs for the primary and secondary prevention of seizures after stroke.
CONCLUSIONS: Currently, there is insufficient evidence to support the routine use of antiepileptic drugs for the primary or secondary prevention of seizures after stroke. Further well-conducted research is needed for this important clinical problem. PMID: 24464793 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 3, 2014 Category: Journals (General) Authors: Sykes L, Wood E, Kwan J Tags: Cochrane Database Syst Rev Source Type: research

Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke.
CONCLUSIONS: The available trial evidence showed that, for individuals with acute ischaemic stroke, GP IIb-IIIa inhibitors are associated with a significant risk of intracranial haemorrhage with no evidence of any reduction in death or disability in survivors. These data do not support their routine use in clinical practice. The conclusion is driven by trials of Abciximab, which contributed 89% of the total number of study participants considered. PMID: 24609741 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - March 8, 2014 Category: Journals (General) Authors: Ciccone A, Motto C, Abraha I, Cozzolino F, Santilli I Tags: Cochrane Database Syst Rev Source Type: research

Interventions for improving sit-to-stand ability following stroke.
CONCLUSIONS: This review has found insufficient evidence relating to our primary outcome of ability to sit-to-stand independently to reach any generalisable conclusions. This review has found moderate quality evidence that interventions to improve sit-to-stand may have a beneficial effect on time taken to sit-to-stand and lateral symmetry during sit-to-stand, in the population of people with stroke who were already able to sit-to-stand independently. There was insufficient evidence to reach conclusions relating to the effect of interventions to improve sit-to-stand on peak vertical ground reaction force, functional ability...
Source: Cochrane Database of Systematic Reviews - May 26, 2014 Category: Journals (General) Authors: Pollock A, Gray C, Culham E, Durward BR, Langhorne P Tags: Cochrane Database Syst Rev Source Type: research

Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
CONCLUSIONS: This review does not provide the evidence to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of patients with acute ischemic or hemorrhagic stroke. Chlormethiazole appeared to be beneficial in improving functional independence in patients with TACS according to the subgroup analysis, but this result must be interpreted with great caution. More well-designed RCTs with large samples of TACS would be required for further confirmation. However, somnolence and rhinitis are frequent adverse events related to chlormethiazole. PMID: 25097101 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 6, 2014 Category: Journals (General) Authors: Liu J, Wang LN Tags: Cochrane Database Syst Rev Source Type: research

Interventions for improving community ambulation in individuals with stroke.
CONCLUSIONS: There is currently insufficient evidence to establish the effect of community ambulation interventions or to support a change in clinical practice. More research is needed to determine if practicing outdoor or community walking will improve participation and community ambulation skills for stroke survivors living in the community. PMID: 25767912 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - March 13, 2015 Category: Journals (General) Authors: Barclay RE, Stevenson TJ, Poluha W, Ripat J, Nett C, Srikesavan CS Tags: Cochrane Database Syst Rev Source Type: research

Transcranial direct current stimulation (tDCS) for improving aphasia in patients with aphasia after stroke.
CONCLUSIONS: Currently there is no evidence of the effectiveness of tDCS (anodal tDCS, cathodal tDCS and bihemispheric tDCS) versus control (sham tDCS) for improving functional communication, language impairment and cognition in people with aphasia after stroke. Further RCTs are needed in this area to determine the effectiveness of this intervention. Authors of future research should adhere to the CONSORT Statement. PMID: 25929694 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 1, 2015 Category: Journals (General) Authors: Elsner B, Kugler J, Pohl M, Mehrholz J Tags: Cochrane Database Syst Rev Source Type: research

Cerebrolysin for acute ischaemic stroke.
CONCLUSIONS: Routine administration of Cerebrolysin to people with acute ischaemic stroke cannot be supported by the available evidence from RCTs. PMID: 26083192 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 17, 2015 Category: Journals (General) Authors: Ziganshina LE, Abakumova T Tags: Cochrane Database Syst Rev Source Type: research

Fibrates for secondary prevention of cardiovascular disease and stroke.
CONCLUSIONS: Moderate evidence showed that the fibrate class can be effective in the secondary prevention of composite outcome of non-fatal stroke, non-fatal MI, and vascular death. However, this beneficial effect relies on the inclusion of clofibrate data, a drug that was discontinued in 2002 due to its unacceptably large adverse effects. Further trials of the use of fibrates in populations with previous stroke and also against a background treatment with statins (standard of care) are required. PMID: 26497361 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 25, 2015 Category: Journals (General) Authors: Wang D, Liu B, Tao W, Hao Z, Liu M Tags: Cochrane Database Syst Rev Source Type: research

Speech and language therapy for aphasia following stroke.
CONCLUSIONS: Our review provides evidence of the effectiveness of SLT for people with aphasia following stroke in terms of improved functional communication, reading, writing, and expressive language compared with no therapy. There is some indication that therapy at high intensity, high dose or over a longer period may be beneficial. HIgh-intensity and high dose interventions may not be acceptable to all. PMID: 27245310 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 31, 2016 Category: Journals (General) Authors: Brady MC, Kelly H, Godwin J, Enderby P, Campbell P Tags: Cochrane Database Syst Rev Source Type: research