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Source: Cochrane Database of Systematic Reviews

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Total 466 results found since Jan 2013.

Oral antiplatelet therapy for acute ischaemic stroke
CONCLUSIONS: Antiplatelet therapy with aspirin 160 mg to 300 mg daily, given orally (or by nasogastric tube or per rectum in people who cannot swallow) and started within 48 hours of onset of presumed ischaemic stroke, significantly decreased death and dependency, and reduced the risk of early recurrent ischaemic stroke without a major risk of early haemorrhagic complications; long-term outcomes were improved.PMID:35028933 | DOI:10.1002/14651858.CD000029.pub4
Source: Cochrane Database of Systematic Reviews - January 14, 2022 Category: General Medicine Authors: Jatinder S Minhas Tamara Chithiramohan Xia Wang Sam C Barnes Rebecca H Clough Meeriam Kadicheeni Lucy C Beishon Thompson Robinson Source Type: research

Interventions for perceptual disorders following stroke
CONCLUSIONS: Following a detailed, systematic search, we identified limited RCT evidence of the effectiveness of interventions for perceptual disorders following stroke. There is insufficient evidence to support or refute the suggestion that perceptual interventions are effective. More high-quality trials of interventions for perceptual disorders in stroke are needed. They should recruit sufficient participant numbers, include a 'usual care' comparison, and measure longer-term functional outcomes, at time points beyond the initial intervention period. People with impaired perception following a stroke should continue to re...
Source: Cochrane Database of Systematic Reviews - November 3, 2022 Category: General Medicine Authors: Christine Hazelton Katie Thomson Alex Todhunter-Brown Pauline Campbell Charlie Sy Chung Liam Dorris David C Gillespie Susan M Hunter Kris McGill Donald J Nicolson Linda J Williams Marian C Brady Source Type: research

Physical fitness training for stroke patients.
CONCLUSIONS: The effects of training on death and dependence after stroke are unclear. Cardiorespiratory training reduces disability after stroke and this may be mediated by improved mobility and balance. There is sufficient evidence to incorporate cardiorespiratory and mixed training, involving walking, within post-stroke rehabilitation programs to improve the speed and tolerance of walking; improvement in balance may also occur. There is insufficient evidence to support the use of resistance training. Further well-designed trials are needed to determine the optimal content of the exercise prescription and identify long-t...
Source: Cochrane Database of Systematic Reviews - October 21, 2013 Category: Journals (General) Authors: Saunders DH, Sanderson M, Brazzelli M, Greig CA, Mead GE Tags: Cochrane Database Syst Rev Source Type: research

Transcranial direct current stimulation (tDCS) for improving function and activities of daily living in patients after stroke.
CONCLUSIONS: At the moment, evidence of very low to low quality is available on the effectiveness of tDCS (anodal/cathodal/dual) versus control (sham/any other intervention) for improving ADL performance and function after stroke. Future research should investigate the effects of tDCS on lower limb function and should address methodological issues by routinely reporting data on adverse events and dropouts and allocation concealment, and by performing intention-to-treat analyses. PMID: 24234980 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 15, 2013 Category: Journals (General) Authors: Elsner B, Kugler J, Pohl M, Mehrholz J Tags: Cochrane Database Syst Rev Source Type: research

Rehabilitation for improving automobile driving after stroke.
CONCLUSIONS: There was insufficient evidence to reach conclusions about the use of rehabilitation to improve on-road driving skills after stroke. We found limited evidence that the use of a driving simulator may be beneficial in improving visuocognitive abilities, such as road sign recognition that are related to driving. Moreover, we were unable to find any RCTs that evaluated on-road driving lessons as an intervention. At present, it is unclear which impairments that influence driving ability after stroke are amenable to rehabilitation, and whether the contextual or remedial approaches, or a combination of both, are more...
Source: Cochrane Database of Systematic Reviews - February 25, 2014 Category: Journals (General) Authors: George S, Crotty M, Gelinas I, Devos H Tags: Cochrane Database Syst Rev Source Type: research

Anticoagulants for acute ischaemic stroke.
CONCLUSIONS: Since the last version of the review, no new relevant studies have been published and so there is no additional information to change the conclusions. Early anticoagulant therapy is not associated with net short- or long-term benefit in people with acute ischaemic stroke. Treatment with anticoagulants reduced recurrent stroke, deep vein thrombosis and pulmonary embolism, but increased bleeding risk. The data do not support the routine use of any of the currently available anticoagulants in acute ischaemic stroke. PMID: 25764172 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - March 12, 2015 Category: Journals (General) Authors: Sandercock PA, Counsell C, Kane EJ Tags: Cochrane Database Syst Rev Source Type: research

Motivational interviewing for improving recovery after stroke.
CONCLUSIONS: There is insufficient evidence to support the use of motivational interviewing for improving activities of daily living after stroke. Further well designed RCTs are needed. PMID: 26037617 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - June 3, 2015 Category: Journals (General) Authors: Cheng D, Qu Z, Huang J, Xiao Y, Luo H, Wang J Tags: Cochrane Database Syst Rev Source Type: research

Pharmacological interventions other than botulinum toxin for spasticity after stroke.
CONCLUSIONS: The lack of high-quality RCTs limited our ability to make specific conclusions. Evidence is insufficient to determine if systemic antispasmodics are effective at improving function following stroke. PMID: 27711973 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 5, 2016 Category: Journals (General) Authors: Lindsay C, Kouzouna A, Simcox C, Pandyan AD Tags: Cochrane Database Syst Rev Source Type: research

Cerebrolysin for acute ischaemic stroke.
CONCLUSIONS: The findings of this Cochrane Review do not demonstrate clinical benefits of cerebrolysin for treating acute ischaemic stroke. We found moderate-quality evidence suggesting that serious adverse events may be more common with cerebrolysin use in acute ischaemic stroke. PMID: 27918088 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 4, 2016 Category: Journals (General) Authors: Ziganshina LE, Abakumova T, Vernay L Tags: Cochrane Database Syst Rev Source Type: research

Interventions for dysarthria due to stroke and other adult-acquired, non-progressive brain injury.
CONCLUSIONS: We found no definitive, adequately powered RCTs of interventions for people with dysarthria. We found limited evidence to suggest there may be an immediate beneficial effect on impairment level measures; more, higher quality research is needed to confirm this finding.Although we evaluated five studies, the benefits and risks of interventions remain unknown and the emerging evidence justifies the need for adequately powered clinical trials into this condition.People with dysarthria after stroke or brain injury should continue to receive rehabilitation according to clinical guidelines. PMID: 28121021 [PubMe...
Source: Cochrane Database of Systematic Reviews - January 24, 2017 Category: Journals (General) Authors: Mitchell C, Bowen A, Tyson S, Butterfint Z, Conroy P Tags: Cochrane Database Syst Rev Source Type: research