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Source: Circulation Research
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Total 159 results found since Jan 2013.
PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation
CONCLUSIONS: Patients with AF exhibit increased levels of PPP1R12C protein compared with controls. PPP1R12C overexpression in mice increases PP1c targeting to MLC2a and causes MLC2a dephosphorylation, which reduces atrial contractility and increases AF inducibility. These findings suggest that PP1 regulation of sarcomere function at MLC2a is a key determinant of atrial contractility in AF.PMID:37737016 | DOI:10.1161/CIRCRESAHA.123.322516
Source: Circulation Research - September 22, 2023 Category: Cardiology Authors: Srikanth Perike Francisco J Gonzalez-Gonzalez Issam Abu-Taha Frederick W Damen Laurin M Hanft Ken S Lizama Anahita Aboonabi Andrielle E Capote Yuriana Aguilar-Sanchez Benjamin Levin Zhenbo Han Arvind Sridhar Jacob Grand Jody Martin Joseph G Akar Chad M Wa Source Type: research
Role of Dickkopf-3 in Blood Pressure Regulation in Mice and Hypertensive Rats
CONCLUSIONS: These findings demonstrate that Dkk3 acts as peripheral and central regulator of BP by promoting VEGF expression and activating a VEGF/Akt/eNOS hypotensive axis.PMID:37144413 | DOI:10.1161/CIRCRESAHA.122.321744
Source: Circulation Research - May 5, 2023 Category: Cardiology Authors: Carla Letizia Busceti Albino Carrizzo Franca Bianchi Massimiliano De Lucia Antonio Damato Chiara Cazzin Eleonora Venturini Paola Di Pietro Roxana Paula Ginerete Luisa Di Menna Maria Cotugno Rosita Stanzione Simona Marchitti Serena Migliarino Michele Cicca Source Type: research
A Critical Role for ERO1 α in Arterial Thrombosis and Ischemic Stroke
CONCLUSIONS: Our results suggest that ERO1α acts as a thiol oxidase for Ca2+ signaling molecules, STIM1 and SERCA2, and enhances cytosolic Ca2+ levels, promoting platelet activation and aggregation. Our study provides evidence that ERO1α may be a potential target to reduce thrombotic events.PMID:37132383 | DOI:10.1161/CIRCRESAHA.122.322473
Source: Circulation Research - May 3, 2023 Category: Cardiology Authors: Vishwanath Jha Bei Xiong Tripti Kumari Gavriel Brown Jinzhi Wang Kyungho Kim Jingu Lee Nathan Asquith John Gallagher Lillian Asherman Taylor Lambert Yanyan Bai Xiaoping Du Jeong-Ki Min Rajan Sah Ali Javaheri Babak Razani Jin-Moo Lee Joseph E Italiano Jaeh Source Type: research
Platelets at the Vessel Wall in Non-Thrombotic Disease
Circ Res. 2023 Mar 17;132(6):775-790. doi: 10.1161/CIRCRESAHA.122.321566. Epub 2023 Mar 16.ABSTRACTPlatelets are small, anucleate entities that bud from megakaryocytes in the bone marrow. Among circulating cells, platelets are the most abundant cell, traditionally involved in regulating the balance between thrombosis (the terminal event of platelet activation) and hemostasis (a protective response to tissue injury). Although platelets lack the precise cellular control offered by nucleate cells, they are in fact very dynamic cells, enriched in preformed RNA that allows them the capability of de novo protein synthesis which ...
Source: Circulation Research - March 17, 2023 Category: Cardiology Authors: Anu Aggarwal Courtney L Jennings Emily Manning Scott J Cameron Source Type: research
Hypoxia Sensing of β-Adrenergic Receptor Is Regulated by Endosomal PI3Kγ
CONCLUSIONS: Agonist-independent activation of PI3Kγ underlies hypoxia sensing as its ablation leads to reduction in β1- and β2AR phosphorylation and amelioration of cardiac dysfunction.PMID:36779349 | DOI:10.1161/CIRCRESAHA.122.321735
Source: Circulation Research - February 13, 2023 Category: Cardiology Authors: Yu Sun Kate Stenson Maradumane L Mohan Manveen K Gupta Nick Wanner Kewal Asosingh Serpil Erzurum Sathyamangla V Naga Prasad Source Type: research
Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression
CONCLUSIONS: Circulating IL-6 predicts carotid plaque severity, vulnerability, and progression. The 2.0 pg/mL cutoff could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.PMID:35713008 | DOI:10.1161/CIRCRESAHA.122.320877
Source: Circulation Research - June 17, 2022 Category: Cardiology Authors: Joseph Kamtchum-Tatuene Luca Saba Mirjam R Heldner Michiel H F Poorthuis Gert J de Borst Tatjana Rundek Stavros K Kakkos Seemant Chaturvedi Raffi Topakian Joseph F Polak Glen C Jickling Carotid Atherosclerosis and Stroke Collaboration (CASCO) Source Type: research
