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Source: Circulation Research
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Total 159 results found since Jan 2013.
Advances in Acute Ischemic Stroke Therapy
Circ Res. 2022 Apr 15;130(8):1230-1251. doi: 10.1161/CIRCRESAHA.121.319948. Epub 2022 Apr 14.ABSTRACTThe treatment of acute ischemic stroke continues to advance. The mainstay of treatment remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later treatment with alteplase is beneficial in patients selected with advanced imaging techniques. Tenecteplase has been evaluated as an alternative thrombolytic drug and evidence suggests that it is as least as effective as alteplase and may lyse large vessel clots more effectively. Endovascular therapy with mechanical thrombectomy has now been shown to be...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Yunyun Xiong Ajay K Wakhloo Marc Fisher Source Type: research
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Circ Res. 2022 Apr 15;130(8):1204-1229. doi: 10.1161/CIRCRESAHA.121.319949. Epub 2022 Apr 14.ABSTRACTIntracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and mortality. This review article focuses on the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of ICH. Incidence of hemorrhagic stroke has increased worldwide over the past 40 years, with shifts in the cause over time as hypertension management has improved and anticoagulant use has increased. Preclinical and clinical trials have elucidated the underlying ICH cause and mechanisms of i...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Jessica Magid-Bernstein Romuald Girard Sean Polster Abhinav Srinath Sharbel Romanos Issam A Awad Lauren H Sansing Source Type: research
Introduction to the Compendium on Stroke and Neurocognitive Impairment
Circ Res. 2022 Apr 15;130(8):1073-1074. doi: 10.1161/CIRCRESAHA.122.321073. Epub 2022 Apr 14.NO ABSTRACTPMID:35420917 | DOI:10.1161/CIRCRESAHA.122.321073
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Costantino Iadecola Marc Fisher Ralph L Sacco Source Type: research
Cerebrovascular Complications of COVID-19 and COVID-19 Vaccination
Circ Res. 2022 Apr 15;130(8):1187-1203. doi: 10.1161/CIRCRESAHA.122.319954. Epub 2022 Apr 14.ABSTRACTThe risk of stroke and cerebrovascular disease complicating infection with SARS-CoV-2 has been extensively reported since the onset of the pandemic. The striking efforts of many scientists in cooperation with regulators and governments worldwide have rapidly brought the development of a large landscape of vaccines against SARS-CoV-2. The novel DNA and mRNA vaccines have offered great flexibility in terms of antigen production and led to an unprecedented rapidity in effective and safe vaccine production. However, as mass vac...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Manuela De Michele Joshua Kahan Irene Berto Oscar G Schiavo Marta Iacobucci Danilo Toni Alexander E Merkler Source Type: research
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke
Circ Res. 2022 Apr 15;130(8):1167-1186. doi: 10.1161/CIRCRESAHA.121.319994. Epub 2022 Apr 14.ABSTRACTInflammation and immune mechanisms are crucially involved in the pathophysiology of the development, acute damage cascades, and chronic course after ischemic stroke. Atherosclerosis is an inflammatory disease, and, in addition to classical risk factors, maladaptive immune mechanisms lead to an increased risk of stroke. Accordingly, individuals with signs of inflammation or corresponding biomarkers have an increased risk of stroke. Anti-inflammatory drugs, such as IL (interleukin)-1β blockers, methotrexate, or colchicine, r...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Matthias Endres Maria A Moro Christian H Nolte Claudia Dames Marion S Buckwalter Andreas Meisel Source Type: research
Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives
We describe how, in recent years, large-scale genome-wide association studies have enabled major progress in deciphering the genetic basis for stroke and its subtypes, although more research is needed to interpret these findings. We cover the potential of stroke genetics to reveal novel pathophysiological processes underlying stroke, to accelerate the discovery of new therapeutic approaches, and to identify individuals in the population who are at high risk of stroke and could be targeted for tailored preventative interventions.PMID:35420914 | DOI:10.1161/CIRCRESAHA.122.319950
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: St éphanie Debette Hugh S Markus Source Type: research
Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome
Circ Res. 2022 Apr 15;130(8):1112-1144. doi: 10.1161/CIRCRESAHA.122.319983. Epub 2022 Apr 14.ABSTRACTThe microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and their host. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional and functional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses to disease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability of microbiota and its host to restore a symbiotic state. Dysbiosis leads to d...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Pedram Honarpisheh Robert M Bryan Louise D McCullough Source Type: research
Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications
Circ Res. 2022 Apr 15;130(8):1145-1166. doi: 10.1161/CIRCRESAHA.122.320110. Epub 2022 Apr 14.ABSTRACTStroke remains a leading cause of death and disability, with limited therapeutic options and suboptimal tools for diagnosis and prognosis. High throughput technologies such as proteomics generate large volumes of experimental data at once, thus providing an advanced opportunity to improve the status quo by facilitating identification of novel therapeutic targets and molecular biomarkers. Proteomics studies in animals are largely designed to decipher molecular pathways and targets altered in brain tissue after stroke, wherea...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Karin Hochrainer Wei Yang Source Type: research
Cerebrovascular Complications of COVID-19 and COVID-19 Vaccination
Circ Res. 2022 Apr 15;130(8):1187-1203. doi: 10.1161/CIRCRESAHA.122.319954. Epub 2022 Apr 14.ABSTRACTThe risk of stroke and cerebrovascular disease complicating infection with SARS-CoV-2 has been extensively reported since the onset of the pandemic. The striking efforts of many scientists in cooperation with regulators and governments worldwide have rapidly brought the development of a large landscape of vaccines against SARS-CoV-2. The novel DNA and mRNA vaccines have offered great flexibility in terms of antigen production and led to an unprecedented rapidity in effective and safe vaccine production. However, as mass vac...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Manuela De Michele Joshua Kahan Irene Berto Oscar G Schiavo Marta Iacobucci Danilo Toni Alexander E Merkler Source Type: research
Immune Pathways in Etiology, Acute Phase, and Chronic Sequelae of Ischemic Stroke
Circ Res. 2022 Apr 15;130(8):1167-1186. doi: 10.1161/CIRCRESAHA.121.319994. Epub 2022 Apr 14.ABSTRACTInflammation and immune mechanisms are crucially involved in the pathophysiology of the development, acute damage cascades, and chronic course after ischemic stroke. Atherosclerosis is an inflammatory disease, and, in addition to classical risk factors, maladaptive immune mechanisms lead to an increased risk of stroke. Accordingly, individuals with signs of inflammation or corresponding biomarkers have an increased risk of stroke. Anti-inflammatory drugs, such as IL (interleukin)-1β blockers, methotrexate, or colchicine, r...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Matthias Endres Maria A Moro Christian H Nolte Claudia Dames Marion S Buckwalter Andreas Meisel Source Type: research
Stroke Genetics: Discovery, Insight Into Mechanisms, and Clinical Perspectives
We describe how, in recent years, large-scale genome-wide association studies have enabled major progress in deciphering the genetic basis for stroke and its subtypes, although more research is needed to interpret these findings. We cover the potential of stroke genetics to reveal novel pathophysiological processes underlying stroke, to accelerate the discovery of new therapeutic approaches, and to identify individuals in the population who are at high risk of stroke and could be targeted for tailored preventative interventions.PMID:35420914 | DOI:10.1161/CIRCRESAHA.122.319950
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: St éphanie Debette Hugh S Markus Source Type: research
Aging Microbiota-Gut-Brain Axis in Stroke Risk and Outcome
Circ Res. 2022 Apr 15;130(8):1112-1144. doi: 10.1161/CIRCRESAHA.122.319983. Epub 2022 Apr 14.ABSTRACTThe microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbes and their host. Many environmental and host-related factors affect the gut microbiota. Dysbiosis is defined as compositional and functional alterations of the gut microbiota that contribute to the pathogenesis, progression and treatment responses to disease. Dysbiosis occurs when perturbations of microbiota composition and function exceed the ability of microbiota and its host to restore a symbiotic state. Dysbiosis leads to d...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Pedram Honarpisheh Robert M Bryan Louise D McCullough Source Type: research
Stroke Proteomics: From Discovery to Diagnostic and Therapeutic Applications
Circ Res. 2022 Apr 15;130(8):1145-1166. doi: 10.1161/CIRCRESAHA.122.320110. Epub 2022 Apr 14.ABSTRACTStroke remains a leading cause of death and disability, with limited therapeutic options and suboptimal tools for diagnosis and prognosis. High throughput technologies such as proteomics generate large volumes of experimental data at once, thus providing an advanced opportunity to improve the status quo by facilitating identification of novel therapeutic targets and molecular biomarkers. Proteomics studies in animals are largely designed to decipher molecular pathways and targets altered in brain tissue after stroke, wherea...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Karin Hochrainer Wei Yang Source Type: research
Post-Stroke Cognitive Impairment and Dementia
Circ Res. 2022 Apr 15;130(8):1252-1271. doi: 10.1161/CIRCRESAHA.122.319951. Epub 2022 Apr 14.ABSTRACTPoststroke cognitive impairment and dementia (PSCID) is a major source of morbidity and mortality after stroke worldwide. PSCID occurs as a consequence of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage. Cognitive impairment and dementia manifesting after a clinical stroke is categorized as vascular even in people with comorbid neurodegenerative pathology, which is common in elderly individuals and can contribute to the clinical expression of PSCID. Manifestations of cerebral small vessel disease, such...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Natalia S Rost Amy Brodtmann Matthew P Pase Susanne J van Veluw Alessandro Biffi Marco Duering Jason D Hinman Martin Dichgans Source Type: research
Advances in Recurrent Stroke Prevention: Focus on Antithrombotic Therapies
Circ Res. 2022 Apr 15;130(8):1075-1094. doi: 10.1161/CIRCRESAHA.121.319947. Epub 2022 Apr 14.ABSTRACTThe past decade has seen significant advances in stroke prevention. These advances include new antithrombotic agents, new options for dyslipidemia treatment, and novel techniques for surgical stroke prevention. In addition, there is greater recognition of the benefits of multifaceted interventions, including the role of physical activity and dietary modification. Despite these advances, the aging of the population and the high prevalence of key vascular risk factors pose challenges to reducing the burden of stroke. Using a ...
Source: Circulation Research - April 14, 2022 Category: Cardiology Authors: Brian Mac Grory Shadi Yaghi Charlotte Cordonnier Luciano A Sposato Jose G Romano Seemant Chaturvedi Source Type: research
